Cough due to ace inhibitors: a case-control study using automated general practice data

Visser, L. E.; Vlug, A. E.; Lei, Johan van der; Stricker, B. H. C.

doi:10.1007/s002280050047

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…The prior evidence of this association was based on a large number of case reports and two large studies based on GP data. The IPCI database has been used to study the association between ACE inhibitors and cough [7]. The source population for this study was patients from 10 general practices in the period 1 September 1992 to 1 March 1994.…”

Section: Validationmentioning

confidence: 99%

Postmarketing Surveillance Based on Electronic Patient Records: The IPCI Project

Vlug¹,

Lei²,

Mosseveld³

et al. 1999

Methods Inf Med

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153

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Researchers claim that data in electronic patient records can be used for a variety of purposes including individual patient care, management, and resource planning for scientific research. Our objective in the project Integrated Primary Care Information (IPCI) was to assess whether the electronic patient records of Dutch general practitioners contain sufficient data to perform studies in the area of postmarketing surveillance studies. We determined the data requirements for postmarketing surveil-lance studies, implemented additional software in the electronic patient records of the general practitioner, developed an organization to monitor the use of data, and performed validation studies to test the quality of the data. Analysis of the data requirements showed that additional software had to be installed to collect data that is not recorded in routine practice. To avoid having to obtain informed consent from each enrolled patient, we developed IPCI as a semianonymous system: both patients and participating general practitioners are anonymous for the researchers. Under specific circumstances, the researcher can contact indirectly (through a trusted third party) the physician that made the data available. Only the treating general practitioner is able to decode the identity of his patients. A Board of Supervisors predominantly consisting of participating general practitioners monitors the use of data. Validation studies show the data can be used for postmarketing surveillance. With additional software to collect data not normally recorded in routine practice, data from electronic patient record of general practitioners can be used for postmarketing surveillance.

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Section: Validationmentioning

confidence: 99%

Postmarketing Surveillance Based on Electronic Patient Records: The IPCI Project

Vlug¹,

Lei²,

Mosseveld³

et al. 1999

Methods Inf Med

Self Cite

153

View full text Add to dashboard Cite

show abstract

“…To test the quality of the data in the IPCI database, three epidemiological studies were performed to confirm well-known adverse reactions to drugs: the association between the use of ACE-inhibitors and cough (18), antibiotics and skin reactions (19), and fluoroquinolones and tendinitis (20). All these validation studies were able to confirm the positive associations that had been reported previously.…”

Section: Post-marketing Surveillancementioning

confidence: 92%

Medical Informatics Research and Education at the Erasmus University in Rotterdam

Kors

Lei²,

Bemmel³

2001

Yearb Med Inform

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“…Applied to the drug-safety system, the inputsystem of the central database can not be validated, because it is a fully automated process. The PMS-module is validated by a group of GPs and the database system including research tools by a scientific researcher (Visser, Vlug, Van der Lei and Stricker, 1996). The whole system including the protocols of anonymization, encryption and the role of the Supervisory Board is validated by the participating doctors.…”

Section: Hard Systems Methodology: Concepts and Methodsmentioning

confidence: 99%

In Search of an Integrative Vision for Technology

Strijbos¹,

Basden²

2006

Contemporary Systems Thinking

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Cough due to ace inhibitors: a case-control study using automated general practice data

Cited by 4 publications

References 16 publications

Postmarketing Surveillance Based on Electronic Patient Records: The IPCI Project

Postmarketing Surveillance Based on Electronic Patient Records: The IPCI Project

Medical Informatics Research and Education at the Erasmus University in Rotterdam

In Search of an Integrative Vision for Technology

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