Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth: report of two cases

Shelekhova, Ksenya V.; Kazakov, Dmitry V.; Michal, Michal

doi:10.1007/s00428-006-0329-8

Cited by 15 publications

(15 citation statements)

References 8 publications

(13 reference statements)

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“…An extrauterine cotyledonoid part and intrauterine dissecting fascicles of disorganized, swirled neoplastic smooth muscle with hydropic degeneration and foci of intravascular growth of the tumor characterize both neoplasms described. These features are similar to those detected in previously described cases of Sternberg tumor [2,5,6,14,16].…”

Section: Discussionsupporting

confidence: 87%

“…The age range in the literature is 23-73 years, with most patients in the reproductive age group [2,14], but in our case the patient had been in menopause for 3 years. The lesion may also occur in pregnancy, resulting in clinical symptoms [15].…”

Section: Discussionmentioning

confidence: 66%

“…The cytoplasm contains intermediate filaments and microfilaments with focal densities. There are also abundant collagen fibrils in the matrix [14]. On flow cytometry, cotyledonoid dissecting leiomyoma shows deoxyribonucleic acid diploidy with a relatively low S-phase fraction (5.6%), consistent with a benign nature [13].…”

Section: Discussionmentioning

confidence: 94%

“…The tumors, however, lack nuclear atypia, mitotic activity, or coagulative tumor necrosis, and well-differentiated smooth-muscle cells and the abundance of collagen fibrils in the matrix also imply the benign nature of the tumors. However, the small number of reported cases allows no conclusion on the biological course of the lesions [14]. The combination of these gross and cytological features is quite distinctive but may lead the inexperienced pathologist or surgeon to confuse this entity with sarcoma, particularly on the gross specimen, thus leading to overtreatment [4,12].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, numerous variants of uterine smooth-muscle tumors may be manifestations of a common pathological process [14].…”

Section: Discussionmentioning

confidence: 99%

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Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth in postmenopausal woman: a case presentation

et al. 2011

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Cotyledonoid dissecting leiomyoma ("Sternberg tumor") is an unusual type of a benign uterine smooth-muscle tumor with a distinctive gross appearance. A 57-year-old woman (gravida 7, para 6), in menopause for 3 years, presented with a 3-4-year history of increased pelvic pain. The transvaginal ultrasound scan showed a 2.5 cm sized heterogenic mass in the uterus cavity and 4 × 5 cm sized irregular contoured mass in the right lateral aspect of the uterus. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed with removal of the pelvic tumor extension. Definite pathologic examination result was cotyledonoid dissecting leiomyoma of the uterus with intravascular growth. The patient is receiving follow-up care every 6 months, and she has no evidence of disease after 22 months of follow-up. The worrying appearance of the gross specimen is often mistaken for malignant or non-uterine lesions that may result in overtreatment. It is important to be aware of this entity to prevent overly aggressive treatment for this benign smooth-muscle neoplasm.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

“…Therefore, numerous variants of uterine smooth-muscle tumors may be manifestations of a common pathological process [14].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth in postmenopausal woman: a case presentation

et al. 2011

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Cotyledonoid Leiomyoma Clinical Characteristics, Imaging Features, and Review of the Literature

Buonomo

Bussolaro

Giorda

et al. 2020

J of Ultrasound Medicine

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Cotyledonoid leiomyoma of the uterus is a rare variant of benign uterine leiomyoma. It has a favorable attitude, despite some ultrasound presentations. A bulky uterus with a heterogeneous mass with irregular margins, high vascularity, and infiltration of the myometrium can induce the suspicion of a malignant mesenchymal tumor and lead to a radical surgical treatment. If present, some imaging features may suggest this rare type of leiomyoma, thus avoiding extensive surgery, especially in young nulliparous women. We report 13 cases of cotyledonoid leiomyoma with clinical characteristics, imaging features, and a literature review.

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Cotyledonoid dissecting leiomyoma of the uterus associated with endosalpingiosis

Driss

Zhioua²,

Doghri

et al. 2009

Arch Gynecol Obstet

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Cotyledonoid dissecting leiomyoma (CDL) may create a diagnostic challenge. A 47-year-old woman underwent laparotomy for a large pelvic mass associated to vaginal bleeding. During operation, a bulky deep red mass protruding from the uterus and projecting into the pelvic cavity was discovered. Allowing to sarcoma- like appearance, a total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed with removal of the pelvic tumor extension. The diagnosis of cotyledonoid dissecting leiomyoma of the uterus associated with endosalpingiosis was performed. To the best of our knowledge, this association has never been encountered in the English literature.

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Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth: report of two cases

Cited by 15 publications

References 8 publications

Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth in postmenopausal woman: a case presentation

Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth in postmenopausal woman: a case presentation

Cotyledonoid Leiomyoma Clinical Characteristics, Imaging Features, and Review of the Literature

Cotyledonoid dissecting leiomyoma of the uterus associated with endosalpingiosis

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