Cotransplantation of umbilical cord MSCs to enhance engraftment of hematopoietic stem cells in patients with severe aplastic anemia

Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease

“…1,36 On the one hand, the good responses to immunosuppressive treatments such as antithymocyte globulin and cyclosporine A support the belief that pathological T-cell-mediated autoimmune responses are a cause of the BM failure in AA. 1,34,36 On the other hand, several studies have shown that co-transplantation of allogeneic BM-or CB-derived MSC and HSC enhances hematopoietic engraftment and also improves stromal function in patients with AA, [37][38][39][40] suggesting a potential underlying role of the BM microenvironment in the pathogenesis of AA. In fact, AA patients have a hypocellular BM which is "physiologically" replaced by fatty BM, likely of mesenchymal origin, further supporting a potential contribution of the BM microenvironment to the pathogenesis of AA.…”

Effective Treatment Of Severe Bk Virus-Associated Hemorrhagic Cystitis With Leflunomide In Children After Hematopoietic Stem Cell Transplantation

“…All patients were aged <18 years; all underwent procedures of HSCT as previously reported. 9 The reduction of immunosuppressive agents were adjusted by the severity of graft-versushost disease (GVHD).…”

Umbilical Cord-Derived Mesenchymal Stem Cells for Hematopoietic Stem Cell Transplantation

“…We found that BMMSCs derived from children with severe aplastic anemia exhibit poor potential of proliferation and differentiation [45]. Due to the possibility of BMMSC insufficiency, we cotransplanted UCMSCs along with HSCs in 2 children with severe aplastic anemia [4]. Both achieved faster hematopoietic engraftment without infusion-related toxicities.…”

“…We share our clinical experience in the successful use of in vitro expanded UCMSCs [2–4]. We also describe several issues related to the clinical use of MSCs.…”