Costs, quality of life and treatment compliance associated with antibiotic therapies in patients with cystic fibrosis: a review of the literature

Weiner, Jennifer; Toy, Edmond L.; Sacco, Patricia; Duh, Mei Sheng

doi:10.1517/14656566.9.5.751

Cited by 36 publications

(35 citation statements)

References 54 publications

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“…Indeed, compared with a previous review of randomized controlled trials examining adherence rates for airway clearance techniques (88 -96%), 14 rates for compliance in observational studies reported in the present study are lower (33.3-91.2%). The previous review of adherence to antibiotics (mixed methodologies) reported similar adherence rates (35-87%) 13 compared with the present review (36 -85%).…”

Section: Discussionsupporting

confidence: 82%

“…Adherence rates have been reported to be 67% for oral antibiotics, 31-53% for inhaled antibiotics, 7 33% for dornase alfa, and 40 -70% for chest physical therapy. 3,[8][9][10][11][12] Although adherence levels for subcategories of 2 of the 4 WHO recommendations have been the subject of systematic reviews (adherence to antibiotics only, 13 airway clearance techniques 14 ), the inclusion of randomized controlled trials may not reflect participants' level of adherence to their independent home treatment regimes due to the nature of frequent monitoring as part of being involved in a trial. Hence, this review was undertaken to include all 4 WHO recommendations (nutrition, medication, exercise, pancreatic enzyme replacement therapy) in non-interventional studies.…”

Section: Introductionmentioning

confidence: 99%

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Adherence of Subjects With Cystic Fibrosis to Their Home Program: A Systematic Review

O'Donohoe

Fullen

2014

Respir Care

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BACKGROUND: The management of cystic fibrosis (CF) includes adherence to a home management program (airway clearance, medication, nutritional advice, and exercise). This has led to an increase in life expectancy, although the benefits depend greatly on a patient's level of adherence to daily treatments at home. To date, no systematic review has established adherence rates to all World Health Organization guidelines in the home setting; hence, this review was undertaken. METHODS: The review comprised 3 phases. A methodological assessment of databases (Embase, CINAHL, PsychINFO, PEDro, PubMed, Cochrane Central Register of Controlled Trials) identified potentially relevant papers. These papers were screened for inclusion criteria by 2 independent reviewers, data were extracted, and the internal validity was rated using a valid and reliable scale. Results were categorized into 4 themes: medication, nutrition, airway clearance techniques, and exercise. RESULTS: The search generated a total of 26 papers, 24 of which were rated as being poor quality. Adherence to a treatment program for CF patients is generally low (from 22% for nutritional guidelines to 130% for oral antibiotics), and it varies greatly depending on the type of treatment and the method of assessment employed (objective tool vs self-reported questionnaires). CONCLUSIONS: Consensus on how to measure adherence is lacking, and the quality of studies addressing adherence in this population is generally poor. Overall, studies using self-reported measures yielded higher adherence scores than those that used objective measures, suggesting that current efforts to improve methods of adherence are appropriate. The prevalence of non-adherence remains unclear due to these limitations.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Adherence of Subjects With Cystic Fibrosis to Their Home Program: A Systematic Review

O'Donohoe

Fullen

2014

Respir Care

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“…These data are confirmed by other researchers in other medical fields. For example, it was determined that the lack of readiness to cooperate and oppositional behaviours have a negative effect on adherence to treatment also in patients with cystic fibrosis [28].…”

Section: Discussionmentioning

confidence: 99%

Adherence to treatment after CABG in terms of patients’ personality

et al. 2018

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Abstract. The relevance of the problem is caused by the prevalence of cardiovascular diseases among the population, including coronary heart disease which requires surgical treatment, on the one hand, and low rates of treatment adherence among patients with chronic diseases, which reduce the effectiveness of the treatment and survival rates of patients, on the other hand. Patients after CABG were divided into groups according to the degree of their adherence to treatment and were examined by using the Big Five Questionnaire. Differences between the groups on the scales "conscientiousness" (p < 0.001), "openness" (p < 0.001), "agreeableness" (p < 0.05), and "neuroticism" (p < 0.05) were revealed. The study showed that the psychological factors are relevant in the definition of adherence to treatment and patients' personality traits are potentially significant for the prediction of its degree among patients after CABG.

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“…Weiner et al, 251 from Boston, carried out a literature review examining costs, QoL and compliance with treatment. The cost data are useful and are referred to elsewhere.…”

Section: Medline = 1064 Retrieved Embase = 1281 Retrievedmentioning

confidence: 99%

Screening for cystic fibrosis-related diabetes: a systematic review.

Waugh

Royle²,

Craigie³

et al. 2012

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects...

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Costs, quality of life and treatment compliance associated with antibiotic therapies in patients with cystic fibrosis: a review of the literature

Cited by 36 publications

References 54 publications

Adherence of Subjects With Cystic Fibrosis to Their Home Program: A Systematic Review

Adherence of Subjects With Cystic Fibrosis to Their Home Program: A Systematic Review

Adherence to treatment after CABG in terms of patients’ personality

Screening for cystic fibrosis-related diabetes: a systematic review.

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