Costs and benefits of vertical and horizontal transmission of Dengue virus

Ruiz‐Guzmán, Gloria; Ramos-Castañeda, José; Hernández-Quintero, Angélica; Contreras‐Garduño, Jorge

doi:10.1242/jeb.145102

Cited by 3 publications

(1 citation statement)

References 28 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a recent study shown that, vertical or horizontal viral transmission has no reproductive cost on Ae. aegypti females, suggesting why both types of transmission are sustained evolutionary [111]. Despite the existence of DENV vertical transmission was recently report that asymptomatic infections in human host and infected individuals' movement are more important determinants of DENV's persistence [112].…”

Section: Biological Control Of Pest and Vector Insectsmentioning

confidence: 99%

Transmission of Major Arboviruses in Brazil: The Role of Aedes aegypti and Aedes albopictus Vectors

Chouin-Carneiro¹,

Santos²

2017

Biological Control of Pest and Vector Insects

View full text Add to dashboard Cite

Arthropod-borne viruses (arboviruses) are transmitted to a mammalian host by an infected arthropod vector. More than 130 types of arboviruses are known to cause disease in susceptible vertebrate hosts and are responsible for some of the most explosive epidemics of emerging infectious diseases in recent decades. The transmission cycle requires three essential components: virus, vector and vertebrate. Understanding the role of the vector in the arboviruses transmission is critical to improve emerging arbovirus disease control strategies. Since 2015, Brazil is faced with the challenge of three co-circulating arboviruses of major public health importance. Dengue virus (DENV) infection has been a public health for 30 years, which has suffered several epidemics caused by all four serotypes. The emergence of Chikungunya virus (CHIKV) and Zika virus (ZIKV) in Brazil poses new challenges to clinicians and public health authorities. In urban and suburban areas, those arboviruses are transmitted between people by Aedes mosquitoes in the subgenus Stegomyia, especially Ae. aegypti (the main vector) and potentially Ae. albopictus. Factors relating to the environment and the vector-virus interactions can influence the dynamics of arboviruses transmission. This chapter describes the main biology aspects of the Ae. aegypti and Ae. albopictus that can influence the success of the transmission of main arboviruses in Brazil and provide information to understand the role of those factors in this dynamic relations

show abstract

Section: Biological Control Of Pest and Vector Insectsmentioning

confidence: 99%

Transmission of Major Arboviruses in Brazil: The Role of Aedes aegypti and Aedes albopictus Vectors

Chouin-Carneiro¹,

Santos²

2017

Biological Control of Pest and Vector Insects

View full text Add to dashboard Cite

show abstract

Males can evolve lower resistance to sexually transmitted infections to infect their mates and thereby increase their own fitness

et al. 2019

View full text Add to dashboard Cite

The costs of transgenerational immune priming for homologous and heterologous infections with different serotypes of dengue virus in Aedes aegypti mosquitoes

Cime-Castillo,

Vargas,

Hernández-Tablas

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

The immune system is a network of molecules, signaling pathways, transcription, and effector modulation that controls, mitigates, or eradicates agents that may affect the integrity of the host. In mosquitoes, the innate immune system is highly efficient at combating foreign organisms but has the capacity to tolerate vector-borne diseases. These implications lead to replication, dissemination, and ultimately the transmission of pathogenic organisms when feeding on a host. In recent years, it has been discovered that the innate immune response of mosquitoes can trigger an enhanced immunity response to the stimulus of a previously encountered pathogen. This phenomenon, called immune priming, is characterized by a molecular response that prevents the replication of viruses, parasites, or bacteria in the body. It has been documented that immune priming can be stimulated through homologous organisms or molecules, although it has also been documented that closely related pathogens can generate an enhanced immune response to a second stimulus with a related organism. However, the cost involved in this immune response has not been characterized through the transmission of the immunological experience from parents to offspring by transgenerational immune priming (TGIP) in mosquitoes. Here, we address the impact on the rates of oviposition, hatching, development, and immune response in Aedes aegypti mosquitoes, the mothers of which were stimulated with dengue virus serotypes 2 and/or 4, having found a cost of TGIP on the development time of the progeny of mothers with heterologous infections, with respect to mothers with homologous infections. Our results showed a significant effect on the sex ratio, with females being more abundant than males. We found a decrease in transcripts of the siRNA pathway in daughters of mothers who had been exposed to an immune challenge with DV. Our research demonstrates that there are costs and benefits associated with TGIP in Aedes aegypti mosquitoes exposed to DV. Specifically, priming results in a lower viral load in the offspring of mothers who have previously been infected with the virus. Although some results from tests of two dengue virus serotypes show similarities, such as the percentage of pupae emergence, there are differences in the percentage of adult emergence, indicating differences in TGIP costs even within the same virus with different serotypes. This finding has crucial implications in the context of dengue virus transmission in endemic areas where multiple serotypes circulate simultaneously.

show abstract

Costs and benefits of vertical and horizontal transmission of Dengue virus

Cited by 3 publications

References 28 publications

Transmission of Major Arboviruses in Brazil: The Role of Aedes aegypti and Aedes albopictus Vectors

Transmission of Major Arboviruses in Brazil: The Role of Aedes aegypti and Aedes albopictus Vectors

Males can evolve lower resistance to sexually transmitted infections to infect their mates and thereby increase their own fitness

The costs of transgenerational immune priming for homologous and heterologous infections with different serotypes of dengue virus in Aedes aegypti mosquitoes

Contact Info

Product

Resources

About