In this chapter, some key factors of the companies were analyzed, which during the development of their activities marked positively or negatively their passage through different growth scenarios for the transition from a medium to a large company in a circular economy in Colombia. The methodology that served as the basis of analysis aimed at compiling the information in secondary sources of the growth data in the last five years (2014-2018) of 100 medium and large Colombians with more operational income. Focus explicitly was one those working with the concept of a circular economy, registered in public sources in Colombia, such as the superintendence of companies (Supersocieties) and EMIS database. After this analysis, the findings, conclusions, and steps of the analysis model were identified so that the transition between the different scenarios proposed would produce the expected results to the companies. The working hypothesis was that there are some key factors that allow a medium-sized company to become a large company in a circular economy.