Cost-Utility Analysis of Human Papillomavirus Vaccination and Cervical Screening on Cervical Cancer Patient in Indonesia

Setiawan, Dedy; Dolk, F Christiaan K; Suwantika, Auliya A.; Westra, Tjalke A.; Wilschut, Jan; Postma, Maarten J.

doi:10.1016/j.vhri.2015.10.010

Cited by 20 publications

(21 citation statements)

References 42 publications

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“…A cohort Markov model, that has been developed previously [6], was updated using the latestand country-specific-data to project the epidemiological profile of cervical cancer in Indonesia. The model followed a cohort of 2,277,200 of 10-year-old girls, which are the main target of HPV vaccination policy in 2019, and this cohort was followed until the population is 85 years old.…”

Section: Model Structure and Current Situation In Indonesiamentioning

confidence: 99%

“…Vaccine efficacies on preventing cervical cancer incidence were derived from efficacies data and then adjusted with the HPV infection profile in Indonesia [6,12]. Only high-risk HPV (hrHPV) types, that are considered as the main causes of cervical cancer, were included in this study including HPV type 16, 18, 31, 33, 45, 52, and 58 (Table 1) [13].…”

Section: Hpv Vaccine Efficacy and Coveragementioning

confidence: 99%

“…The initial and recurrent cervical cancer costs were adopted from previous studies [6] and screening and cryotherapy costs were adopted from the national tariffs for cervical cancer prevention policy [18]. All the cost information was converted and updated to 2018 US$ using conversion rate and inflation rate [19].…”

Section: Cost Utility and Discount Ratementioning

confidence: 99%

“…Although the cause of cervical cancer and its prevention strategy has been clearly explained and recommended by several bodies including WHO, the comprehensive implementation of the recommendation, covering HPV vaccination, cervical screening, and cancer treatment as the primary, secondary and tertiary intervention, consecutively, faces some substantial milestone due to several issues for example parent's acceptance, availability of skilled human resources, and most importantly, the required budget.However, several health economic studies showed that the implementation of HPV vaccination and cervical screening are cost-effective strategies in most countries in the world [3][4][5]. Moreover, the implementation of those strategies will also substantially save the national account of Indonesia that should be spent on cervical cancer treatment [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Cervical cancer prevention in Indonesia: An updated clinical impact, cost-effectiveness and budget impact analysis

et al. 2020

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Introduction The clinical and economic impact of cervical cancer consistently become a serious burden for all countries, including Indonesia. The implementation of HPV vaccination policy for a big country such as Indonesia requires a strong commitment from several decision-makers. The aim of this study was to provide a comprehensive description on cost-effectiveness and the budget-impact of HPV vaccination policy in Indonesia. Method A cohort Markov model was used to evaluate the cost and the clinical impact of HPV vaccination for 10 years old girls in Indonesia. The researchers consider two doses of all three available HPV vaccines adjusted with the HPV infection profilewith 95% vaccination coverage to estimate the national cervical cancer incidence and mortality. The Budget impact analysis explores three different scenarios covering (1) Two districts per year expansion, (2) oneprovince per year expansion and (3) achieving the National Immunization Program in 2024. Results Upon fully vaccinating almost 2.3 million 10-year-old girls, 34,723; 43,414; and 51,522 cervical cancer cases were prevented by Quadrivalent, Bivalent and Nonavalent vaccines, consecutively. Furthermore, the highest (591 cases) and lowest (399 cases) mortality were prevented by Nonavalent and Quadrivalent vaccines, respectively. Most of the vaccines were considerably cost-effective and only the Bivalent vaccine with the GAVI/UNICEF price which will be considered a cost-saving strategy.To provide national coverage of HPV vaccination in Indonesia, the government has to provide an annual budget of about US$49 million

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Section: Model Structure and Current Situation In Indonesiamentioning

confidence: 99%

Section: Hpv Vaccine Efficacy and Coveragementioning

confidence: 99%

Section: Cost Utility and Discount Ratementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cervical cancer prevention in Indonesia: An updated clinical impact, cost-effectiveness and budget impact analysis

et al. 2020

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“…Based on the report by the World Health Organization (WHO), cervical cancer is the most common cancer is second only to breast cancer in women that affect women aged 15 to 44 years (Agustina Nurcahyanti DR., 2016). Based on data from the WHO in 2008 estimated daily occur 38 new cases and 21 women die from cervical cancer (Center for Data and Information of the Ministry of Health, 2015) and in 2012 was estimated new cases of cervical cancer in Indonesia as many as 20 928 cases with an incidence of 17.3 per 100,000 women (Didik Setiawan et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Age and parity with pre-cancer lesions in cervical cancer foundation of South Kalimantan Indonesia region 2016-2017

Norazizah¹,

Khofiyah²

2019

Int. Journal Health Scie. Tech.

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Cervical cancer is a gynecologic cancer incidence and cause of death have the second highest in the world, estimated at 80% of cervical cancer cases occur in developing countries. Cervical cancer in its early stages rarely cause complaints and when women consult a medical 70% are at an advanced stage that it is difficult to cure. Cervical cancer is caused due to infection of human papillomavirus (HPV) and exacerbated by several risk factors including age and parity. The purpose of this study was to determine the relationship of age and parity with the incidence of pre-cancerous lesions of the cervix. This is a case- control study comparing cases and controls in each variable. The sample used in this study using a ratio of 1: 1 in 310 people in the control group and 310 as cases of people taken at random by means of the control group and the total sample in the case group. Data collection tools used books patient reports and statistical tests using Chi_Square. The results in this study found an increased risk for 2,049 times in women aged ≥ 35 years and 2,046 fold increased risk in women who have children ≥ 3 with the incidence of pre-cancerous lesions of the cervix. So there is a significant relationship between age and parity with the incidence of pre- cancerous lesions of the cervix. The results in this study found an increased risk for 2,049 times in women aged ≥ 35 years and 2,046 fold increased risk in women who have children ≥ 3 with the incidence of pre-cancerous lesions of the cervix. So there is a significant relationship between age and parity with the incidence of pre-cancerous lesions of the cervix. The results in this study found an increased risk for 2,049 times in women aged ≥ 35 years and 2,046 fold increased risk in women who have children ≥ 3 with the incidence of pre-cancerous lesions of the cervix. So there is a significant relationship between age and parity with the incidence of pre-cancerous lesions of the cervix..

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Cervical Cancer Prevention, Diagnosis, and Management Within a Low-Resource Environment

Lellé

Küppers²

2023

Colposcopy

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Cost-Utility Analysis of Human Papillomavirus Vaccination and Cervical Screening on Cervical Cancer Patient in Indonesia

Cited by 20 publications

References 42 publications

Cervical cancer prevention in Indonesia: An updated clinical impact, cost-effectiveness and budget impact analysis

Cervical cancer prevention in Indonesia: An updated clinical impact, cost-effectiveness and budget impact analysis

Age and parity with pre-cancer lesions in cervical cancer foundation of South Kalimantan Indonesia region 2016-2017

Cervical Cancer Prevention, Diagnosis, and Management Within a Low-Resource Environment

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