Cost savings analysis of intrawound vancomycin powder in posterior spinal surgery

Is Prophylactic Intervention More Cost-effective Than the Treatment of Pathologic Fractures in Metastatic Bone Disease?

“…Although the clinical benefits of prophylactic stabilization have been well established, no studies to our knowledge, have provided a cost analysis comparing costs of this treatment option with the costs of providing care to patients after pathologic fractures have occurred. With the current healthcare focus on cost and value of treatments, physicians should be aware of relative costs of their treatment options [4,5,8,9,14,15,17].…”

Topical intrawound application of vancomycin powder in addition to intravenous administration of antibiotics: A meta-analysis on the deep infection after spinal surgeries

“…Rest, 11 studies were checked in full-text. Three studies [15,18,20] were excluded because of inadequate data on deep infection, deep infection was not determined by bacterial culture and the lack of follow-up information, respectively. Finally, eight studies [5,[12][13][14]16,17,21,22]were included in this meta-analysis.…”

“…The reduction in health care cost is significant considering the vancomycin powder only costs 12-44 US dollars per case [12,18,20]. The reduction of care cost could represent another advantage of this technique.…”

Adverse Drug Reactions to Local Intrawound Vancomycin Application After Posterior Lumbosacral Fusion

“…Именно снижение активно-сти остеобластов и их гибель приво-дят к развитию псевдоартроза -одной из основных нежелательных лекар-ственных реакций при использова-нии ванкомицина [25]. Доза порошка ванкомицина при его местном при-менении с целью профилактики раз-вития ИОХВ у пациентов после опе-раций на позвоночнике в различ-ных клинических сериях варьирует от 1 до 2 г, но большинство исследо-вателей сходятся во мнении, что пре-парат необходимо равномерно рас-пределять по всей площади раневого канала [6,9,11,12,15,17,21,27,31]. Проведение дальнейших исследова-ний in vivo необходимо для опреде-ления оптимальных доз порошка ван-комицина при его местном примене-нии, с одновременным сохранением высокой антибактериальной активно-сти и нивелированием нежелательных лекарственных реакций.…”