Objectives: This article presents a 3-year budget impact simulation on the effects of a chronic Hepatitis C (HCV) eradication plan in real-life costs incurred by the Regional Health Service in the Liguria Region (in Northern Italy).
Methods:The Liguria Region network performed a prospective 3-year (2017-2019) timeframe horizon trends simulation analysis focusing on management interventions and costs. It involved all the eight prescribing centres in the region, starting from retrospective historical performance data and assuming impact of sustained viral response rates for patients treated for HCV. Data on hospital admissions, medical visits, number of patients and deaths were collected through the healthcare database.Results: At the beginning of 2017, 2,940 patients were eligible for HCV treatment with directacting antivirals. Assuming to treat this entire population with a success rate of 90%, the events related to liver complications in the 3-year horizon would decrease to 5,538 cumulatively (-35%), with a 27% reduction of direct costs, showing a global savings of 24,779.024 Euros.
Conclusion:Treating the entire eligible HCV population would lead to significant benefits and savings in managing liver-related diseases and their direct costs, opening opportunities to rethink new settings for the future organisation of liver disease management in the regional health system.