Abstract:globulin have a strong but not exclusive influence.' Changes in albumin have only a minor effect, but paraproteins2 and lipoproteins3 also increase plasma and serum viscosity. For these reasons estimations of plasma fibrinogen from the difference of plasma and serum viscosity are unreliable and can be wrong by as much as 100",.1 According to the authors' own reasoning a quantitative plasma protein determination (electrophoresis) therefore should be more reliable as a predictor of early rheumatic conditions.
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