Cost of pelvic organ prolapse surgery in the United States

Subak, Leslee L.; Waetjen, L. Elaine; Eeden, Stephen Van Den; Thom, David H.; Vittinghoff, Eric; Brown, Jeanette S.

doi:10.1016/s0029-7844(01)01472-7

Cited by 357 publications

(215 citation statements)

References 5 publications

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“…About 50% of parous women have some degree of pelvic organ prolapse [1] although only 10% are symptomatic [2,3]. Oslen et al [2] reported an 11-12% risk of surgery for prolapse in women reaching 79 years of age.…”

Section: Introductionmentioning

confidence: 99%

Review of synthetic mesh-related complications in pelvic floor reconstructive surgery

2008

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There is significant risk of re-operation after pelvic reconstructive surgery. In an attempt to improve outcome, synthetic materials are increasingly being used to augment pelvic organ prolapse repair despite lack of strong evidence to support their routine use. The use of synthetic mesh to correct apical, anterior and posterior vaginal wall prolapse is not without complications. This review aims to evaluate the long-term complications of synthetic mesh in pelvic reconstructive surgery.

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Section: Introductionmentioning

confidence: 99%

Review of synthetic mesh-related complications in pelvic floor reconstructive surgery

2008

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“…It conveys a significant burden on individuals and society, even if it rarely threatens the general health and/or life of the patient. In the United States alone, pelvic organ prolapse is thought to lead to over 200,000 surgical procedures per year, with about 30% being re-operations [1,2], resulting in an annual expenditure of over $1 billion [3]. Female pelvic organ prolapse may give rise to symptoms of vaginal fullness and dragging, with the patient eventually noticing a protrusion from the vagina.…”

Section: Introductionmentioning

confidence: 99%

The aetiology of prolapse

Dietz

2008

Int Urogynecol J

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Female pelvic organ prolapse is a common condition that is said to be multifactorial in aetiology. While a number of risk factors such as vaginal childbirth, obesity and ageing are commonly accepted, it is not clear as to how these risk factors affect the development of prolapse-that is, which pathophysiologic mechanisms are responsible for disease manifestation. Measures used in epidemiological studies, such as presentation for surgical treatment, are generally confounded by other conditions, and evidence is lacking for some of the most frequently quoted aetiological factors. In this paper, I will try to summarise the available evidence in order to separate hearsay and hypothesis from available research findings and to suggest a way forward for diagnosis and treatment.

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“…Treatment for pelvic organ prolapse involves the surgical repair of anatomic defects in pelvic floor fascial support. Each year in the USA, 300,000 to 400,000 women require surgery for pelvic organ prolapse [3] with an annual cost estimated as $1 billion dollars [4].…”

Section: Introductionmentioning

confidence: 99%

COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse

et al. 2008

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The objective of this study was to verify the possible association between the Sp1-binding site polymorphism and genital prolapse. A case-control study was conducted in 107 patients with stages III and IV genital prolapse. The control group included 209 women with stages 0 and I. The polymorphism of type I collagen Sp1-binding site was identified by amplification of the first intron of the COL1A1 gene. We did not find differences in the prevalence of the GT and TT genotypes between the groups (p = 0.34), even when we grouped patients with at least one polymorphic allele (GT and TT) and compared them with patients without the polymorphic allele (GG; p = 0.17) The presence of at least one vaginal delivery, family history for prolapse, and macrosomatic fetus were independent risk factors for prolapse. In conclusion, the COL1A1 Sp1-binding site was not significantly associated with genital prolapse among our study subjects.

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Cost of pelvic organ prolapse surgery in the United States

Abstract: The annual direct costs of operations for pelvic organ prolapse are substantial.

Cited by 357 publications

References 5 publications

Review of synthetic mesh-related complications in pelvic floor reconstructive surgery

Review of synthetic mesh-related complications in pelvic floor reconstructive surgery

The aetiology of prolapse

COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse

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