Cost impact of complications in meningococcal disease: Evidence from a United States managed care population

Davis, Keith L.; Misurski, Derek; Miller, Jacqueline M.; Karve, Sudeep

doi:10.4161/hv.7.4.14434

Cited by 31 publications

(20 citation statements)

References 38 publications

(58 reference statements)

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“…In our study, we found that approximately 13% of IMD patients had an IMD-related complication at discharge of the IMD-related index hospitalization and 23.5% developed a sequela during the follow-up period. The number of IMD patients with sequelae observed in our study was lower compared to other studies ranging between 29% and 58% [7,8,14,22,26,27]; however, these studies are not directly comparable due to regional differences, different study populations (e.g. regarding age), different follow-up durations, diverging case definitions of IMDrelated complications and sequelae and different data sources.…”

Section: Discussioncontrasting

confidence: 89%

“…From the multivariable analysis, we found that the length of hospital stay was longer in patients aged 25 years and older as well as in patients with clinical presentation as other IMD including patients with unspecified and possibly milder meningococcal infections that may have led to shorter hospitalizations. In contrast, another study from the United States reported a mean length of hospital stay of 17.8 days; however, the proportion of complicated IMD cases and the mean age was higher with 41% and 33.2 years, respectively [8]. In our study, we also showed that IMD-related complications observed during the IMD-related index hospitalization are associated with 51% increase of the length of hospital stay.…”

Section: Discussioncontrasting

confidence: 79%

“…In most other studies that investigated specific outcomes, renal complications and sequelae were not investigated or no events were reported [7,14,22,27,29,31]. Davis et al [8] investigated the incidence of IMD complications within one year after initial diagnosis based on administrative claims data between 1998 and 2009 in the United States. Similar to our study, 9% of IMD cases experienced chronic renal failure but no events of adrenal haemorrhage were observed.…”

Section: Discussionmentioning

confidence: 99%

“…A total number of 338 IMD cases were reported according to the infectious disease surveillance in 2016 with the highest incidence observed in children aged 0 to 4 years and a second peak in adolescents aged 15 to 19 years. The case fatality rate of IMD is high with 5-15% and up to 57% of survivors in adolescents aged 15 to 19 years develop a wide range of sequelae [7][8][9][10][11] such as hearing loss, visual impairment, neurological impairments or limb amputation. As a result, IMD is associated with substantial short-term and long-term costs for health care systems [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Clinical and economic burden of invasive meningococcal disease: Evidence from a large German claims database

et al. 2020

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Background Limited data is available to describe clinical characteristics, long-term outcomes, healthcare resource use and the attributable costs of invasive meningococcal disease (IMD) in Germany. We aimed to examine demographic and clinical characteristics as well as healthcare resource use and related costs. Methods We conducted a retrospective cohort study based on the InGef database in patients with IMD between 2009 and 2015. Cases were identified based on hospital main discharge diagnoses of IMD. Demographics, clinical characteristics, 30-day and 1-year mortality as well as IMD-related complications and sequelae in IMD cases were examined. In addition, short and long-term costs and healthcare resource use in IMD cases were analyzed and compared to an age-and sex-matched control group without IMD. Results The study population comprised 164 IMD cases between 2009 and 2015. The mean length of the IMD-related hospitalization was 13 days and 38% of all cases presented with meningitis only, 35% with sepsis only, 16% with both and 11% with other IMD. The 30-day and oneyear mortality were 4.3% and 5.5%, respectively. Approximately 13% of IMD cases had documented IMD-related complications at hospital discharge and 24% suffered from sequelae during follow-up. The IMD-related hospitalization was associated with mean costs of € 9,620 (standard deviation: € 22,197). The difference of mean costs between IMD cases and matched non-IMD controls were € 267 in the first month and € 1,161 from one month to one year after discharged from IMD-related hospitalization. During the later follow-up period, the mean overall costs and costs associated with individual healthcare sectors were also higher for IMD cases without reaching statistical significance.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and economic burden of invasive meningococcal disease: Evidence from a large German claims database

et al. 2020

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“…h Assuming wage loss of $10 per hour for a part-time study worker at OSU (Glassdoor, 2018) and 2 hours spent in travel and receiving medical care. Number of medical encounters obtained from Davis et al (2011b). i Number of units obtained from Dillon, Haubenreiser, Stocker, and Nuttbrock (2018).…”

Section: Estimated Cost Burdenmentioning

confidence: 99%