Cost-Efficiency Optimization Serves as a Conserved Mechanism that Promotes Osteosarcoma in Mammals

Wang, Haibin; Sun, George; Jiang, Yankai

doi:10.1007/s00239-022-10047-3

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…Evolutionary biology could be studied at two distinct time scales. Micro-evolution studies the population genetics at intra-species level (Alonso-Blanco et al 2016;Chu and Wei 2021a;Crow 1955;Park 2011;Wei 2020), while macroevolution studies the phylogenetic tree at inter-species level (Byng et al 2016;Jiang et al 2022;Muller 1995;Wang et al 2022;Yang 1997). These two processes are essentially governed by the same evolutionary rules where novel mutations randomly occur and introduce polymorphisms to a population, and then mutations were subjected to natural selection (and genetic drift) to either be eliminated or be fixed within a species (Chang et al 2021;Webster and Smith 2004).…”

Section: Introductionmentioning

confidence: 99%

Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution

Wang

et al. 2023

J Mol Evol

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Mutations of DNA organisms are introduced by replication errors. However, SARS-CoV-2, as an RNA virus, is additionally subjected to rampant RNA editing by hosts. Both resources contributed to SARS-CoV-2 mutation and evolution, but the relative prevalence of the two origins is unknown. We performed comparative genomic analyses at intra-species (world-wide SARS-CoV-2 strains) and inter-species (SARS-CoV-2 and RaTG13 divergence) levels. We made prior predictions of the proportion of each mutation type (nucleotide substitution) under different scenarios and compared the observed versus the expected. C-to-T alteration, representing C-to-U editing, is far more abundant that all other mutation types. Derived allele frequency (DAF) as well as novel mutation rate of C-to-T are the highest in SARS-CoV-2 population, and C-T substitution dominates the divergence sites between SARS-CoV-2 and RaTG13. This is compelling evidence suggesting that C-to-U RNA editing is the major source of SARS-CoV-2 mutation. While replication errors serve as a baseline of novel mutation rate, the C-to-U editing has elevated the mutation rate for orders of magnitudes and accelerates the evolution of the virus.

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Section: Introductionmentioning

confidence: 99%

Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution

Wang

et al. 2023

J Mol Evol

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The Sponge Interaction Between Circular RNA and microRNA Serves as a Fast-Evolving Mechanism That Suppresses Non-small Cell Lung Cancer (NSCLC) in Humans

Cao

et al. 2022

J Mol Evol

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Cost-Efficiency Optimization Serves as a Conserved Mechanism that Promotes Osteosarcoma in Mammals

Cited by 2 publications

References 49 publications

Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution

Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution

The Sponge Interaction Between Circular RNA and microRNA Serves as a Fast-Evolving Mechanism That Suppresses Non-small Cell Lung Cancer (NSCLC) in Humans

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