Cost-effectiveness randomized clinical trial on the effect of photobiomodulation therapy for prevention of radiotherapy-induced severe oral mucositis in a Brazilian cancer hospital setting

Martins, Allisson Filipe Lopes; Nogueira, Túlio Eduardo; Morais, Marília Oliveira; Sousa-Neto, Sebastião Silvério; Oton-Leite, Angélica Ferreira; Valadares, Marize Campos; Júnior, Ruffo de Freitas; Leles, Cláudio Rodrigues; Mendonça, Elismauro Francisco

doi:10.1007/s00520-020-05607-6

Cited by 15 publications

(7 citation statements)

References 35 publications

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“…In countries where PBM therapy is widely used, the current literature suggests a financial advantage of using it to prevent OM 119 . This cost‐effectiveness analysis may not apply universally.…”

Section: Mucositis and Health Economicsmentioning

confidence: 99%

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies

Sharon

Yarom

Zadik

et al. 2021

CA A Cancer J Clinicians

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Oral mucositis (OM) is a common, highly symptomatic complication of cancer therapy that affects patients' function, quality of life, and ability to tolerate treatment. In certain patients with cancer, OM is associated with increased mortality. Research on the management of OM is ongoing. Oral mucosal toxicities are also reported in targeted and immune checkpoint inhibitor therapies. The objective of this article is to present current knowledge about the epidemiology, pathogenesis, assessment, risk prediction, and current and developing intervention strategies for OM and other ulcerative mucosal toxicities caused by both conventional and evolving forms of cancer therapy.

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Section: Mucositis and Health Economicsmentioning

confidence: 99%

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies

Sharon

Yarom

Zadik

et al. 2021

CA A Cancer J Clinicians

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“…The PBM is recommended for the prevention and treatment of OM in patients receiving cancer treatments. Several studies have demonstrated the effectiveness of anti-inflammatory effects in supporting tissue repair [ 13 , 33 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Nevertheless, clinical evidence still shows that some patients present recurring episodes of OM during their cancer therapy despite being treated with LLLT [ 37 ].…”

Section: Prevention and Management Strategiesmentioning

confidence: 99%

Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review

et al. 2021

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Oral mucositis (OM) is a painful condition caused by chemotherapeutic or radiotherapeutic cancer treatments, occurring in patients with different tumour characteristics and locations. OM greatly impacts a patient’s quality of life and cancer recovery. Current OM management strategies are not providing sufficient prevention and treatment; new approaches to injury management are needed. Studies on the benefit of omega-3 free fatty acids (FFA) in human health have increased significantly in recent years. FFA properties have been studied extensively, including their potential therapeutic use in inflammatory conditions. However, omega-3 FFA’s use as a supplementary treatment for OM has not been clinically tested. Preliminary evidence suggests that utilising FFA to manage OM could be a useful strategy for lesion management, assisting with healthy oral mucosa recovery. This review will describe the incidence, risk factors, biology of OM and the current treatment strategies, leading to a discussion of the utility of omega-3 FFA as a novel therapeutic agent for OM.

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“…In the intervention groups, seven types of nonpharmacological interventions were identified. Specifically, two studies used oral wetting and cleaning agents (Lambrecht et al., 2013; Wong et al., 2017); 10 studies conducted honey treatment (Alvi et al., 2013; Amanat et al., 2017; Bardy et al., 2012; Biswal et al., 2003; Charalambous et al., 2018; Hawley et al., 2014; Jayalekshmi et al., 2016; Maiti et al., 2012; Motallebnejad et al., 2008; Rashad et al., 2009); 10 studies provided low‐level laser therapy (Antunes et al., 2013; Gautam et al., 2012; Gouvêa de Lima et al., 2012; Kauark‐Fontes et al., 2022; Kuhn et al., 2008; Legouté et al., 2019; Lopes Martins et al., 2021; Marín‐Conde et al., 2019; Nugent et al., 2022; Oton‐Leite et al., 2015); seven studies treated patients with natural plant‐based therapies, including natural plant extract mouthwashes (Aghamohammadi et al., 2018; Arantes et al., 2021; Kong et al., 2016; You et al., 2009), and natural plant extract capsules (Arun et al., 2020; Delavarian et al., 2019; Soni et al., 2022); 13 studies provided participants with nutritional supplements (Bakr et al., 2021; Büntzel et al., 2010; Chattopadhyay et al., 2014; Dastan et al., 2020; Demir Doğan et al., 2017; Ertekin et al., 2004; Fernandes et al., 2022; Hamstra et al., 2018; Huang et al., 2019; Lozano et al., 2021; Onseng et al., 2017; Sangthawan et al., 2013; Tsujimoto et al., 2015); six studies used microecological preparations (De Sanctis et al., 2019; Jiang et al., 2019; Manifar et al., 2022; Mirza et al., 2022; Sharma et al., 2012; Xia et al., 2021); and the rem...…”

Section: Resultsmentioning

confidence: 99%

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

Zhang,

Li,

Zhang

et al. 2024

Journal of Clinical Nursing

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Aims and ObjectivesTo assess the effectiveness of different nonpharmacological treatments for severe radiation‐induced oral mucositis in patients with head and neck cancer.BackgroundRadiation‐induced oral mucositis is highly prevalent in patients with head and neck cancer. Current medications for radiation‐induced oral mucositis are limited in effectiveness and susceptible to side effects, and while there is an increasing adoption of nonpharmacological interventions, the optimal one remains unclear.DesignSystematic review and network meta‐analysis based on the PRISMA‐NMA guidelines.MethodsSix databases were searched. Two authors independently performed the literature screening, data extraction and methodological quality assessment of the included studies. Traditional pairwise meta‐analysis was performed by R Studio. A network meta‐analysis was then conducted to assess the effects of nonpharmacological interventions for severe radiation‐induced oral mucositis in patients with head and neck cancer.ResultsFifty‐two studies involving seven types of nonpharmacological interventions were enrolled. The network meta‐analysis indicated that natural plant‐based therapies might be the most effective, health education interventions might be the second most effective, and honey might be the third most effective interventions for reducing the incidence of severe radiation‐induced oral mucositis. For reducing the incidence of severe oral mucositis‐related pain, the pairwise meta‐analysis showed that only natural plant‐based therapies and health education interventions were effective.ConclusionsNonpharmacological interventions are effective in the management of severe radiation‐induced oral mucositis among patients with head and neck cancer.Relevance to clinical practiceNonpharmacological interventions are a category of safe and effective adjunctive therapies that should be encouraged in clinical practice.Trial registration detailsCRD42023400745.

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Cost-effectiveness randomized clinical trial on the effect of photobiomodulation therapy for prevention of radiotherapy-induced severe oral mucositis in a Brazilian cancer hospital setting

Cited by 15 publications

References 35 publications

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies

Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review

Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials

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