“…In the accompanying editorial, Garbi and Mariani4 discuss the complexities of cost-effectiveness analysis in the NHS system and point out that “the recently published UK National Institute for Heath and Care Excellence (NICE) clinical guidelines recommend TEER for secondary mitral regurgitation as well. Furthermore, as part of the development process of the NICE guidelines, a cost-effectiveness analysis complementary to the NHS England Commissioning through Evaluation (CtE) was performed.…”