Cost effectiveness of three drugs for the treatment of S. aureus infections in Nigeria

Suleiman, Ismail A.; Bamiro, Babajide S.; Tayo, Fola

doi:10.1007/s11096-012-9671-x

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…Colonization of wounds by Staphylococcus aureus and rapid proliferation within damaged tissues often lead to disseminated infections [13,14]. Staphylococcus aureus is notorious for its ability to become resistant to antibiotics [15,16]. Plasmids are extrachromosomal DNA molecules that have been shown to carry genes for antibiotics resistance, a single plasmid can carry genes for resistance to multiple antibiotics [17].…”

Section: Introductionmentioning

confidence: 99%

Antibiotics Susceptibility Patterns and Plasmid Profile of Staphylococcus aureus Isolated from Patients with Wound Infections Attending Four Hospitals in Akure, Ondo State

Oluyele

Oladunmoye

2017

JAMB

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Aims: Several studies have documented Staphylococcus aureus as a leading pathogen implicated in wound infections with a remarkable potential for antibiotics resistance. This study determined the susceptibility patterns of S. aureus isolated from wound infections to conventional antibiotics and assessed the plasmid profile of selected multidrug resistant isolates. Study Design: This study was designed to determine the antibiotics susceptibility patterns of Staphylococcus aureus isolates from wound infections.

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Section: Introductionmentioning

confidence: 99%

Antibiotics Susceptibility Patterns and Plasmid Profile of Staphylococcus aureus Isolated from Patients with Wound Infections Attending Four Hospitals in Akure, Ondo State

Oluyele

Oladunmoye

2017

JAMB

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“…In resistant isolates, amikacin was dominantly more cost-effective when compared to meropenem and imipenem [6]. As per Canadian study conducted by Chow et al, showed clindamycin dominated other drugs such as cephalexin, cloxacillin, levofloxacin, and amoxicillin+clavulanate with the lowest CER in the treatment of DFT [12].…”

Section: Discussionmentioning

confidence: 90%

“…Antibiotic resistance is a major worldwide problem, and its implication on public health is becoming overwhelming [4][5][6]. Culture test helps to identify the causative organism and the effective drugs against these organisms can be determined by susceptibility tests.…”

Section: Introductionmentioning

confidence: 99%

Appropriate Empirical Management of Microbial Infections in a Tertiary Care Hospital: A Cost- Effectiveness Approach.

N¹,

Simon²,

Tomy³

et al. 2018

Asian J Pharm Clin Res

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Objective: Antibiotics are mostly prescribed empirically to decrease health-care costs. This has led to the misuse of antibiotics thereby making them inefficient in the treatment of infections. The aim of this study was to determine the appropriate, cost-effective drug for the empirical therapy in microbial infections.Methods: A prospective observational study was conducted for a period of 6 months. Cost-effectiveness ratio (CER) of these antibiotics prescribed was calculated to determine the cost-effective drugs for the common microorganisms and common infections.Results: In a population of 205 patients, 54.6% were treated based on antibiotic sensitivity pattern whereas 45.3% were treated empirically. In known microbial infections, the prevailing microorganism was extended-spectrum beta-lactamase (ESBL) producing Escherichia-coli (14.3%), Staphylococcus aureus (10.6%), Pseudomonas aeruginosa (9.8%), Klebsiella pneumonia (9.8%), and K. pneumoniae ESBL (6.81%). Based on the CER, the most cost-effective drugs for these organisms were found to be ciprofloxacin, clindamycin, ofloxacin, levofloxacin, and amikacin, respectively. In unknown microbial infection (empirical treatment), Diabetic Foot Infection (DFT) (25.8%), respiratory tract infection (RTI) (23.6%), and urinary tract infection (UTI) (16.1%) were the most common infections. The most cost-effective drugs for these infections were clindamycin, levofloxacin, and azithromycin, respectively. The predominant microorganism in DFT was found to be S. aureus (71%), in UTI was found to be E. coli ESBL (52%), and in RTI were found to be P. aeruginosa (42.4%) and K. pneumonia (32.3%). Conclusion:Appropriate empirical antibiotic treatment is associated with a lower medical cost and a better success rate in patients with microbial infections.

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“…1 They used drug susceptibility results from 463 clinical isolates and then performed a cost-effectiveness analysis * using a decision table as an analytical model. 1 They used drug susceptibility results from 463 clinical isolates and then performed a cost-effectiveness analysis * using a decision table as an analytical model.…”

Section: Ciprofloxacin Conquers Staph Infectionsmentioning

confidence: 99%

Costs of infections investigated in Nigeria

2012

Pharmacoecon. Outcomes News

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Cost effectiveness of three drugs for the treatment of S. aureus infections in Nigeria

Abstract: Ciprofloxacin should be used as first-line-treatment of S aureus in Lagos as it will lead to significant cost savings in the treatment of S. aureus infections.

Cited by 4 publications

References 11 publications

Antibiotics Susceptibility Patterns and Plasmid Profile of Staphylococcus aureus Isolated from Patients with Wound Infections Attending Four Hospitals in Akure, Ondo State

Antibiotics Susceptibility Patterns and Plasmid Profile of Staphylococcus aureus Isolated from Patients with Wound Infections Attending Four Hospitals in Akure, Ondo State

Appropriate Empirical Management of Microbial Infections in a Tertiary Care Hospital: A Cost- Effectiveness Approach.

Costs of infections investigated in Nigeria

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