Cost-effectiveness of sulfadoxine-pyrimethamine for the prevention of malaria-associated low birth weight.

Wolfe, Elisabeth B.; Parise, Monica E.; Haddix, Anne C.; Nahlen, Bernard L.; Ayisi, John; Misore, Ambrose; Steketee, Richard W.

doi:10.4269/ajtmh.2001.64.178

Cited by 37 publications

(31 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study evaluated the cost-effectiveness of 3 approaches to malaria chemoprophylaxis compared with case management of malarial disease in areas with variable HIV prevalence and high malaria endemicity. 283 In malaria-endemic areas with high HIV prevalence (Ͼ10%), administering 1 dose of SP prophylaxis per month was more cost-effective, whereas in malaria-endemic areas with low HIV prevalence (Ͻ10%), administering 2 doses of SP prophylaxis during pregnancy was more cost-effective. In any setting, the monthly and the 2-dose strategies were more cost-effective than the case management approach.…”

Section: Ndyomugyenyi Et Al 279mentioning

confidence: 99%

“…The preterm birth rate also was not impacted. An increase in birth weight, however, was observed in nearly all studies 155,[258][259][260][261][262]275,[277][278][279][280][281][282][283][284] ; thus, the evidence for a beneficial effect of chemoprophylaxis on birth weight in endemic areas is strong. Chemoprophylaxis also had a uniformly significant effect in reducing maternal anemia, parasitemia, and/or placental parasite load.…”

Section: Ndyomugyenyi Et Al 279mentioning

confidence: 99%

“…283,694,705 Studies to evaluate even well-established strategies for the improvement of perinatal and neonatal health outcomes, such as breastfeeding promotion in large effectiveness trials, are only now being commissioned. 706 conclusions.…”

Section: Cost-effectiveness Of Community-based Interventionsmentioning

confidence: 99%

See 2 more Smart Citations

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

View full text Add to dashboard Cite

ABSTRACT. Background. Infant and under-5 childhood mortality rates in developing countries have declined significantly in the past 2 to 3 decades. However, 2 critical indicators, maternal and newborn mortality, have hardly changed. World leaders at the United Nations Millennium Summit in September 2000 agreed on a critical goal to reduce deaths of children <5 years by two thirds, but this may be unattainable without halving newborn deaths, which now comprise 40% of all under-5 deaths. Greater emphasis on wide-scale implementation of proven, cost-effective measures is required to save women's and newborns' lives. Approximately 99% of neonatal deaths take place in developing countries, mostly in homes and communities. A comprehensive review of the evidence base for impact of interventions on neonatal health and survival in developingcountry communities has not been reported.Objective. This review of community-based antenatal, intrapartum, and postnatal intervention trials in developing countries aimed to identify (1) key behaviors and interventions for which the weight of evidence is sufficient to recommend their inclusion in communitybased neonatal care programs and (2) key gaps in knowledge and priority areas for future research and program learning.Methods. Available published and unpublished data on the impact of community-based strategies and interventions on perinatal and neonatal health status outcomes were reviewed. Evidence was summarized systematically and categorized into 4 levels of evidence based on study size, location, design, and reported impact, particularly on perinatal or neonatal mortality. The evidence was placed in the context of biological plausibility of the intervention; evidence from relevant developed-country studies; health care program experience in implementation; and recommendations from the World Health Organization and other leading agencies.Results. A paucity of community-based data was found from developing-country studies on health status impact for many interventions currently being considered for inclusion in neonatal health programs. However, review of the evidence and consideration of the broader context of knowledge, experience, and recommendations regarding these interventions enabled us to categorize them according to the strength of the evidence base and confidence regarding their inclusion now in programs. This article identifies a package of priority interventions to include in programs and formulates research priorities for advancing the state of the art in neonatal health care.Conclusions. This review emphasizes some new findings while recommending an integrated approach to safe motherhood and newborn health. The results of this study provide a foundation for policies and programs related to maternal and newborn health and emphasizes the importance of health systems research and evaluation of interventions. The review offers compelling support for using research to identify the most effective measures to save newborn lives. It also may facilitate dialogue with policy...

show abstract

Section: Ndyomugyenyi Et Al 279mentioning

confidence: 99%

Section: Ndyomugyenyi Et Al 279mentioning

confidence: 99%

See 1 more Smart Citation

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

View full text Add to dashboard Cite

show abstract

“…These include case management with effective antimalarial drugs, presumptive treatment of infants (IPTi) or pregnant women (IPTp) (Schellenberg et al, 2001;Massaga et al, 2003;Shulman et al, 1999;Parise et al, 1998;Wolfe et al, 2001). …”

Section: Malaria Control Measuresmentioning

confidence: 99%

Challenges in malaria control in Sub-Saharan Africa: The vaccine perspective

Lusingu

Seidlein²

2009

Tanzania J Hlth Res

View full text Add to dashboard Cite

Malaria is a life-threatening disease of public health importance, especially in sub-Saharan Africa. It is estimated that about 500 million cases of malaria occur annually and among these 1 million die annually. Children below five years and pregnant women are the most vulnerable groups. Several malaria control measures have been applied such as environmental improvements, use of insecticide impregnated nets, residual indoor spraying, early case detection and treatment with effective antimalarial drugs. However, the adaptation of vector and parasite has so far limited the effect of these interventions. The emergence of resistance against drugs and insecticides requires in response a steady stream of new interventions. Up to the beginning of this millennium, most sub-Saharan African countries have been using chloroquine (CQ) as the first-line antimalarial drug, which had to be replaced with sulphadoxine-pyrimethamine (SP) after resistant parasites had rendered CQ ineffective. Currently the first line treatment of malaria consists of combination therapy which includes an artemisinin derivative. The current approach appears robust but history has taught us to be alert and to expect resistance to emerge. There is a pressing need to develop and deploy complimentary strategies. Adding a protective vaccine to the existing control tools for malaria holds great promise yet no malaria vaccine has ever been licensed despite a large number of attempts. The complexity of malaria parasites and the ability of the parasite to suppress and evade immune responses are formidable challenges. Fortunately, there are several promising antimalarial vaccine candidates in the development pipeline. The most promising vaccine candidate is RTSS which is currently tested in various countries in sub-Saharan Africa, including two sites in Tanzania. There is a hope that malaria vaccines could be developed and deployed in malaria endemic communities. This article highlights the challenges of developing and deploying malaria vaccines.

show abstract

“…Most malaria-endemic countries have adopted PAM-prevention measures such as insecticide-treated bednets (ITNs) use and intermittent preventive therapy during pregnancy with sulfadoxinepyrimethamine (IPTp-SP) [2,3]. Both ITNs and IPTp-SP are clinically and cost-effective interventions to prevent PAM-associated low birth-weight (LBW) [4][5][6][7]. Ambitious targets are endorsed for near-universal deployment of these interventions [8], though uptake in sub-Saharan Africa is inadequate [3].…”

mentioning

confidence: 99%

Quantification of the Burden and Consequences of Pregnancy-Associated Malaria in the Democratic Republic of the Congo

Taylor¹,

Eijk²,

Hand³

et al. 2011

The Journal of Infectious Diseases

View full text Add to dashboard Cite

Background. Pregnancy-associated malaria (PAM) produces poor birth outcomes, but its prevalence is commonly estimated in convenience samples.Methods. We assessed the prevalence of malaria using real-time polymerase chain reaction (PCR) and estimated the consequences of infection on birth outcomes, using specimens from a nationally representative sample of 4570 women of childbearing age (WOCBA) . By contrast, P malariae was less common in pregnant (0.6%) compared with nonpregnant women (2.7%, PR 0.23 [0.09-0.56]). Extrapolation of the prevalence estimate to the population at risk of malaria in DRC suggests 1.015 million births are affected by P falciparum infection annually, and that adherence to preventive measures could prevent up to 549 000 episodes of pregnancy-associated malaria and 47 000 low-birthweight births.Conclusions. Pregnancy-associated malaria and its consequences are highly prevalent in the DRC. Increasing the uptake of malaria preventive measures represents a significant opportunity to improve birth outcomes and neonatal health.

show abstract

Cost-effectiveness of sulfadoxine-pyrimethamine for the prevention of malaria-associated low birth weight.

Cited by 37 publications

References 34 publications

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Challenges in malaria control in Sub-Saharan Africa: The vaccine perspective

Quantification of the Burden and Consequences of Pregnancy-Associated Malaria in the Democratic Republic of the Congo

Contact Info

Product

Resources

About