Cost-Effectiveness of Single-Dose Methotrexate Compared With Laparoscopic Treatment of Ectopic Pregnancy

Single dose methotrexate for the treatment of unruptured ectopic pregnancy: experience in Kemaman Hospital, Terengganu, Malaysia

“…Medical treatment with methotrexate was first introduced as a successful treatment option for EP in the 1980's by Tanaka et al 9 Many literatures give different success rate of medical management in resolving an EP. A study conducted in Saudi Arabia revealed a 72% success rate, whilst study in Scandinavia and Makkah showed a success rate of 78% and 100% respectively.…”

MTX Could Be First-Line Therapy Even in Cases Where hCG Level is Greater than 5,000 IU/ml

“…Cornual implantation is usually identified in the upper and lateral uterine cavity, whereas interstitial ectopic pregnancy is within the proximal intramural portion of the tube. Therefore, the accurate diagnosis of an interstitial pregnancy requires precise ultrasound imaging (14). Two regimens are commonly used for the administration of MTX (15) ( Table 3).…”

Bleeding in Early Pregnancy

“…A single dose of injection methotrexate 50 mg/sq m intra muscularly proves to be effective in most [4,5] but it may be repeated in few cases [6]. The advantage is avoiding surgical intervention and the disadvantages include the requirement of follow up and the toxicity of the cytotoxic drug used.…”