Cost Effectiveness of Pneumococcal Vaccination in Children in Low- and Middle-Income Countries: A Systematic Review

Saokaew, Surasak; Rayanakorn, Ajaree; Wu, David Bin-Chia; Chaiyakunapruk, Nathorn

doi:10.1007/s40273-016-0439-3

Cited by 49 publications

(41 citation statements)

References 55 publications

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“…Central to the success on full coverage of immunization is rooted at modifying how their parents think about the efficacy of the vaccines and the need for immunization, i.e., parental behavior intention. 6,7 Previous studies have identified potential barriers to increasing the child's immunization rates, including: vaccination costs, vaccine knowledge or misconceptions, distance and waiting time for vaccination, and vaccine acceptance among children and parents. [7][8][9][10] Strategies have been proposed to reduce these barriers, including reducing the family's vaccination expenditures, enhancing parents' knowledge and attitudes towards children's vaccination, and eliminating vaccine allergies.…”

Section: Introductionmentioning

confidence: 99%

Predicting behavioral intentions to children vaccination among Chinese parents: an extended TPB model

Min

Zhao

Kong

et al. 2018

Human Vaccines & Immunotherapeutics

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Parental behavioral intentions play a key role in children vaccination. The present study looks at how parental expectations for the vaccination influence their attitudes and behavioral intentions toward children's immunization. The theoretical model is developed on TPB model and empirically tested with sample data from 380 children aged 0-7 years in mainland China. The structural equation modeling and multi-group analysis were used in the model to demonstrate the impact of the vaccination services quality, vaccination promotions and public opinions on attitudes and vaccination behavioral intention. Results support the study's hypotheses and indicate that Vaccination Services Quality (VSQ), Vaccination Promotions (VAP) and Public Opinions (PUO) have positive effects on Attitudes (ATT) and Vaccination Behavioral Intention (VAI), VSQ has the strongest standardized path (.594) while PUO has the least influence (.131), and Attitude is complete mediation in all paths. Attitude is key factor that determine the parental behavioral intentions, and the internal perception comes from the vaccination services quality and the external influence comes from the social environment affect the parental attitude. Governments should implement effective policies and improve vaccination services quantity to eliminate parental misunderstandings.

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Section: Introductionmentioning

confidence: 99%

Predicting behavioral intentions to children vaccination among Chinese parents: an extended TPB model

Min

Zhao

Kong

et al. 2018

Human Vaccines & Immunotherapeutics

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show abstract

“…35 By reducing the carriage of S. pneumoniae and transmission to contacts, there also has been a concordant decline in the incidence of IPD among the non-vaccinated population. 36 As other published economic have reported, 15,31 the herd effects of vaccinations have a substantial impact on the economic outcomes of PCV-13. When the herd effect was included, our model outputs found that the ICERs of a PCV-13 vaccination program Figure 2.…”

Section: Discussionmentioning

confidence: 94%

“…One recent systematic review has reported that an infant PCV vaccination program was a cost-effective strategy in most low-and middle-income countries (LMICs), including 22 economic evaluations conducted in LMICs. 31 The PCV-13 price per dose in LMICs varied from $3.50 in GAVI-eligible countries to $30 in GAVI-ineligible countries, except for Thailand (»$63) and China (»$58). Our analysis was consistent with the Thai cost-utility analysis, which showed that PCV vaccinations with PCV-10 and PCV13 are not cost-effective even when indirect vaccine effects were considered.…”

Section: Discussionmentioning

confidence: 99%

Cost-effectiveness analysis of routine 13-valent pneumococcal conjugate vaccinations in Chinese infants

Zhou

et al. 2018

Human Vaccines & Immunotherapeutics

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“…In the specific case of pneumococcal vaccines, the scientific evidence on safety evaluation, immunogenicity, the effect on the carrier status and dose schedules comparisons have been widely supported in literature and it based on hard designs of clinical studies involving large cohorts of vaccines and follow-up of systematic reviews and metanalysis [17][18][19][20][21][22]. For this reason, the generation of evidences of the new Cuban vaccine should be rigorous enough to ensure international comparisons and it's positioning as product in vaccine markets.…”

Section: Process Of Scientific Evidence Generationmentioning

confidence: 99%

“…Cots-effectiveness systematic review qbout Pneumococcal Vaccination in Children in Low-and Middle-Income Countries[22]. It s demonstrated that an infant PCV programme was a cost-effective intervention in most LMICs (in 20 of 22 studies included).…”

mentioning

confidence: 99%

Evaluation Strategy to Support the Introduction the New Cuban Conjugated Pneumococcal Vaccine in the National Health System

Linares-Pérez¹,

Toledo-Romaní²,

Mederos³

et al. 2017

J Vaccines Vaccin

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Objective: To present the evaluation framework supporting the clinical, epidemiological and impact studies to introduce the new Cuban conjugated pneumococcal vaccine in the national vaccination program. Methods: The design of the evaluation strategy of the new vaccine in the Cuban included: the revision of the scientific evidence available in literature, the definition of the evaluation objectives, the application of conceptual and methodological evaluation frame, the performance of the process to generate the new scientific evidences about the new vaccine. The regulatory frame for the evaluation and introduction of new PCVs were taken into consideration during the whole process. Results: The background of licensed pneumococcal vaccine with similarly based studies was synthetized. The evaluation strategy of the Cuban vaccine was presented in terms of objectives, key processes, and main components (context evaluation, generation of evidence for making-decisions, introduction of the new vaccine and impact evaluation). The procedures to collect information and analysis of the new evidence generated on PCV7-TT are defined (characterize the study problem, the functioning of the new vaccine, and cost-effectiveness and impact). The evaluation strategy is operationalized in the Cuban context, where preschool children and infants are defined as target population. The contributions, strengths and weaknesses in the evaluation design and in the generation of evidences are discussed. Conclusions: The rigorous scientific evidences generated by the implementation evaluation strategies, applied to the new Cuban conjugated pneumococcal vaccine will allow the decision-making for its introduction to national health system in Cuba.

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Cost Effectiveness of Pneumococcal Vaccination in Children in Low- and Middle-Income Countries: A Systematic Review

Cited by 49 publications

References 55 publications

Predicting behavioral intentions to children vaccination among Chinese parents: an extended TPB model

Predicting behavioral intentions to children vaccination among Chinese parents: an extended TPB model

Cost-effectiveness analysis of routine 13-valent pneumococcal conjugate vaccinations in Chinese infants

Evaluation Strategy to Support the Introduction the New Cuban Conjugated Pneumococcal Vaccine in the National Health System

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