Cost-effectiveness of New Antiplatelet Regimens Used as Secondary Prevention of Stroke or Transient Ischemic Attack

Sarasin, François; Gaspoz, Jean‐Michel; Bounameaux, H

doi:10.1001/archinte.160.18.2773

Cited by 62 publications

(25 citation statements)

References 32 publications

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“…This figure, however, would appear to be cost effective when considering that reported costs per QALY for clopidogrel treatment in stroke prevention approach £17 000. 16 Furthermore, costs per QALY after lumbar discectomy have been reported to be as high as £22 000. 17 Acute costs for treatment have only been considered here.…”

Section: Discussionmentioning

confidence: 99%

Cost-Effective Outcome for Treating Poor-Grade Subarachnoid Hemorrhage

Wilby

Sharp

Whitfield

et al. 2003

Stroke

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Background and Purpose-The goal of this study was to prospectively assess outcome and cost for poor-grade subarachnoid hemorrhage patients presenting to a regional neurosurgical center (Addenbrooke's Hospital, Cambridge, UK) between 1994 and 2001. Outcome measures were clinical outcome at 6 months, number needed to treat (NNT) for favorable outcomes, and cost analysis. Methods-Poor-grade patients (World Federation of Neurological Surgeons grades 4 and 5) were transferred to the neurocritical care unit after intubation and ventilation. After resuscitation and drainage of ventricular cerebrospinal fluid for 24 hours, sedation was stopped, and patients were assessed clinically. Patients with a Glasgow Motor Score (GMS) Ն4 underwent angiography and surgical treatment of culprit aneurysms. Patients with a subsequent GMS of 6 were not deemed poor grade and were discounted from the study. Results-We

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Section: Discussionmentioning

confidence: 99%

Cost-Effective Outcome for Treating Poor-Grade Subarachnoid Hemorrhage

Wilby

Sharp

Whitfield

et al. 2003

Stroke

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“…The fourth study was based on patients with prior TIA or nondisabling ischemic stroke. 35 The latter study was included because patients with prior TIA or stroke are at higher risk for coronary heart disease. Coronary heart disease was considered as an outcome in all these studies.…”

Section: Aspirin Doses In Established Cadmentioning

confidence: 99%

Primary and Secondary Prevention of Cardiovascular Disease

Vandvik

Lincoff

Gore

et al. 2012

Chest

415

118

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“…283,284 However, even small reductions in vascular events compared with aspirin may make combination dipyridamole and aspirin or clopidogrel costeffective from a broader societal perspective. 285 For patients intolerant to aspirin because of allergy or gastrointestinal side effects, clopidogrel is an appropriate choice. Dipyridamole is not tolerated by some patients because of persistent headache.…”

Section: Selection Of Oral Antiplatelet Therapymentioning

confidence: 99%

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack

Sacco¹,

Adams²,

Albers³

et al. 2006

Stroke

1,446

297

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Abstract-The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on the prevention of ischemic stroke among survivors of ischemic stroke or transient ischemic attack. Evidence-based recommendations are included for the control of risk factors, interventional approaches for atherosclerotic disease, antithrombotic treatments for cardioembolism, and the use of antiplatelet agents for noncardioembolic stroke. Further recommendations are provided for the prevention of recurrent stroke in a variety of other specific circumstances, including arterial dissections; patent foramen ovale; hyperhomocysteinemia; hypercoagulable states; sickle cell disease; cerebral venous sinus thrombosis; stroke among women, particularly with regard to pregnancy and the use of postmenopausal hormones; the use of anticoagulation after cerebral hemorrhage; and special approaches for the implementation of guidelines and their use in high-risk populations. (Stroke. 2006;37:577-617.)

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Cost-effectiveness of New Antiplatelet Regimens Used as Secondary Prevention of Stroke or Transient Ischemic Attack

Abstract: To prevent stroke in high-risk patients, dipyridamole combined with aspirin was more effective and less costly than aspirin alone, and clopidogrel was cost-effective compared with current standards of medical practice, except in extreme scenarios.

Cited by 62 publications

References 32 publications

Cost-Effective Outcome for Treating Poor-Grade Subarachnoid Hemorrhage

Cost-Effective Outcome for Treating Poor-Grade Subarachnoid Hemorrhage

Primary and Secondary Prevention of Cardiovascular Disease

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack

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