“…Systematic reviews have been published, which summarize the efficacy and safety of NPWT for treatment of acute and chronic wounds. [1][2][3][4][5] Additional research has focused on cost, 6,7 gauze-based NPWT systems, 8 and the science behind the therapy, including the mechanism of action of vacuum assistance, 9,10 tissue pressure, 11 granulation tissue formation, 12 microvascular blood fl ow, 13 and intermittent versus continuous pressure. 14 However, Gregor and colleagues 15 reported a sy stematic review and meta-analysis of randomized controlled and nonrandomized clinical trials, comparing conventional therapy to NPWT in acute and chronic wounds.…”