Cost-effectiveness of MR imaging in evaluating polymyositis.

Schweitzer, Mark E.; Fort, John

doi:10.2214/ajr.165.6.7484589

Cited by 78 publications

(46 citation statements)

References 16 publications

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“…of biopsy site, MRI has been proven useful as a guide for biopsy location, thereby increasing the probability of a positive result [9][10][11]. MRI is not a replacement for biopsy in distinguishing between PM and inclusion body myositis (IBM).…”

Section: Examinations Of Large Muscle Volumesmentioning

confidence: 99%

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Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies

Park

Olsen

2001

Curr Rheumatol Rep

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Magnetic resonance imaging (MRI) and P-31 magnetic resonance spectroscopy (P-31 MRS) provide unique, quantitative data that cannot be obtained from routine laboratory tests. MRI is the method of choice for imaging of muscle abnormalities. It is also a very sensitive technique for localizing nonhomogeneous inflammation in inflammatory myopathies such as dermatomyositis, juvenile dermatomyositis, amyopathic dermatomyositis, polymyositis, and inclusion body myositis. During treatment of inflammatory myopathies, the extent and severity of inflammation may decrease at varying rates, but weakness and fatigue remain serious clinical problems. The metabolic abnormalities detected with P-31 MRS are more persistent and can be used for objective patient evaluation after the disappearance of inflammation and normalization of serum levels of muscle enzymes. With P-31 MRS, biochemical defects are quantitated, including low levels of ATP and phosphocreatine (PCr) and elevated concentrations of ADP and inorganic phosphate (Pi), which may all be related to weakness and fatigue. Thus, MRI and P-31 MRS are useful in assessing the status of patients with inflammatory myopathies during treatment with prednisone and immunosuppressive drugs.

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Section: Examinations Of Large Muscle Volumesmentioning

confidence: 99%

“…In one cost-effectiveness analysis of MRI, 25 patients with inflammatory diseases were observed over a period of 2 years [10]. Fourteen of the patients had an MRI evaluation to determine the best site for biopsy.…”

Section: Mri Cost Considerations and Cost-effectivenessmentioning

confidence: 99%

Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies

Park

Olsen

2001

Curr Rheumatol Rep

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“…Therefore, the biopsy should be guided by imaging to reduce the false-negative rate of 10-25% when performed without imaging guidance [15,16,21]. Besides MRI, which has advantages, such as whole-body imaging [15] but also the already mentioned limitations [16], CEUS is a possible alternative for guiding biopsy, especially in patients with a previous negative or non-specific biopsy.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced Ultrasound in Dermatomyositis- and Polymyositis

Weber¹,

Jappe²,

Essig³

et al. 2006

J Neurol

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“…Only muscle biopsy can establish the definite diagnosis [45,46], but muscle inflammation may be spotty and idiopathic inflammatory myopathies range from focal varieties confined to a single muscle to diffuse forms [46]. Thus, MRI has been proposed to better guide a biopsy in an area of active disease [1,24,46,47] given the false-negative rate of 10-25% without imaging guidance [48][49][50]. Whole-body MRI [48] further improves the diagnostic utility.…”

Section: Diagnosismentioning

confidence: 99%

“…Treatment monitoring in DM and PM is primarily based on neurological examination assessing muscle strength by manual testing and evaluation of serum CK concentration. However, decrease in serum CK Time in seconds T2* signal intensity 50 100 150 200 250 300 Normal T2* time course (BOLD response) during reactive hyperaemia PAOD PAOD Fig. 4 Idealized T2* time course (BOLD response) in calf muscles of a healthy volunteer during reactive hyperemia after suprasystolic cuff compression according to [42].…”

Section: Treatment Monitoringmentioning

confidence: 99%

Quantitative evaluation of muscle perfusion with CEUS and with MR

2007

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Functional imaging might increase the role of imaging in muscular diseases, since alterations of muscle morphology alone are not specific for a particular disease. Perfusion, i.e., the blood flow per tissue and time unit including capillary flow, is an important functional parameter. Pathological changes of skeletal muscle perfusion can be found in various clinical conditions, such as degenerative or inflammatory myopathies or peripheral arterial occlusive disease. This article reviews the theoretical basics of functional radiological techniques for assessing skeletal muscle perfusion and focuses on contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) techniques. Also, the applications of microvascular imaging, such as in detection of myositis and for discriminating myositis from other myopathies or evaluating peripheral arterial occlusive disease, are presented, and possible clinical indications are discussed. In conclusion, dedicated MR and CEUS methods are now available that visualize and quantify (patho-)physiologic information about microcirculation within skeletal muscles in vivo and hence establish a useful diagnostic tool for muscular diseases.

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Cost-effectiveness of MR imaging in evaluating polymyositis.

Abstract: OBJECTIVE.Polymyositis is an inflammatory disorder of muscle that is often difficult to diagnose.

Cited by 78 publications

References 16 publications

Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies

Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies

Contrast-enhanced Ultrasound in Dermatomyositis- and Polymyositis

Quantitative evaluation of muscle perfusion with CEUS and with MR

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