Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia-Infected Mosquitos and Health Education

Suwantika, Auliya A.; Kautsar, Angga Prawira; Supadmi, Woro; Zakiyah, Neily; Abdulah, Rizky; Ali, Mohammad; Postma, Maarten J.

doi:10.3390/ijerph17124217

Cited by 13 publications

(15 citation statements)

References 41 publications

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“…Due to the limitations presented by the aforementioned strategies, preventive treatment or treatment during a viral infection, as well as the control of the mosquito vector itself, different studies have been conducted to assess the impacts of these tools in isolation or in association [ 51 , 52 ].…”

Section: Disease Overviewmentioning

confidence: 99%

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil

et al. 2023

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Arboviruses constitute the largest known group of viruses. These viruses are the etiological agents of pathologies known as arboviruses, with dengue being one of the most prevalent. Dengue has resulted in important socioeconomic burdens placed on different countries around the world, including those in Latin America, especially Brazil. Thus, this work intends to carry out a narrative-based review of the literature, conducted using a study of the secondary data developed through a survey of scientific literature databases, and to present the situation of dengue, particularly its distribution in these localities. Our findings from the literature demonstrate the difficulties that managers face in controlling the spread of and planning a response against dengue, pointing to the high cost of the disease for public coffers, rendering the resources that are already limited even scarcer. This can be associated with the different factors that affect the spread of the disease, including ecological, environmental, and social factors. Thus, in order to combat the disease, it is expected that targeted and properly coordinated public policies need to be adopted not only in specific localities, but also globally.

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Section: Disease Overviewmentioning

confidence: 99%

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil

et al. 2023

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“…In Indonesia, the sharp reduction in the rate of Dengue fever cases was observed following the release of Wolbachia infected mosquitoes [ 175 ]. It was found to be a highly cost effective method which could give even better results when combined with vaccines [ 176 ]. Although viral evolution could lead to selection of resistant strains, multiple mutations in the viral genome would be required to overcome the broad mode of action of Wolbachia , without losing virus competence to both human and insect tissue [ 177 ].…”

Section: Preventive Measures For Controlling Vector-borne Viral Diseasesmentioning

confidence: 99%

Vector-Borne Viral Diseases as a Current Threat for Human and Animal Health—One Health Perspective

Socha

Kwasnik

Larska

et al. 2022

JCM

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Over the last decades, an increase in the emergence or re-emergence of arthropod-borne viruses has been observed in many regions. Viruses such as dengue, yellow fever, or zika are a threat for millions of people on different continents. On the other hand, some arboviruses are still described as endemic, however, they could become more important in the near future. Additionally, there is a group of arboviruses that, although important for animal breeding, are not a direct threat for human health. Those include, e.g., Schmallenberg, bluetongue, or African swine fever viruses. This review focuses on arboviruses and their major vectors: mosquitoes, ticks, biting midges, and sandflies. We discuss the current knowledge on arbovirus transmission, ecology, and methods of prevention. As arboviruses are a challenge to both human and animal health, successful prevention and control are therefore only possible through a One Health perspective.

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“…Learning from the experience of rotavirus, pneumococcal conjugate vaccine (PCV), dengue, and hepatitis A vaccines, several economic evaluation studies have been conducted in Indonesia to assist the government on the potential introduction of these new vaccines [12][13][14][15][16][17]. Several studies recommended that new vaccines can be considered as cost-effective interventions to be implemented in Indonesia.…”

Section: Economic Evaluations Of New Vaccinesmentioning

confidence: 99%

Sustainable Financing for New Vaccines in Indonesia: Challenges and Strategies

et al. 2020

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Immunization is one of the most cost-effective interventions in global health and has a crucial role in achieving 14 of the 17 sustainable development goals (SDGs). The issue of sustainable financing for new vaccines is particularly pertinent as Indonesia transitions away from extensive Gavi support towards a self-financing immunization system. As the current immunization system transitions, practical solutions must be found and applied to provide more flexibility in the budget for financing immunizations without sacrificing the current healthcare system’s needs. Despite the fact that economic evaluation studies are essential as an initial step to ensure financial readiness, the lack of reliable data is the first barrier to Indonesia’s journey toward a self-financing immunization system. To overcome this problem, standardization of data collection strategies and methodologies are required. In particular, Indonesia may have to explore other options to increase revenue for its immunization system, such as through general revenue from the central government, a sector-wide approach to financing, and a national trust fund. To deal with the tight immunization budget and its consequences, Indonesia also has to restructure its immunization system, which can be implemented through province block grants, insurance mandate and subsidy. Taking the potential of a COVID-19 vaccine into account, the Indonesian government should consider a number of costs and issues beyond the development and procurement of vaccines. The costs of delivering vaccines to the remote parts of Indonesia, implementing the necessary infrastructure, and modifying vaccine delivery are also important in this time of transition. These constraints must be addressed in the new self-financing system and other public health efforts must be increased to decrease the burden of infectious disease as Indonesia develops a stronger immunization system.

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Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia-Infected Mosquitos and Health Education

Cited by 13 publications

References 41 publications

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil

Vector-Borne Viral Diseases as a Current Threat for Human and Animal Health—One Health Perspective

Sustainable Financing for New Vaccines in Indonesia: Challenges and Strategies

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