Ischemic stroke is a leading cause of death and permanent disability.
This disease may affect any age group and especially in old age and
pregnancy. All the responsible mechanisms are yet not completely
understood. There is limited therapeutic intervention beyond prevention,
yet tremendous progress in understanding cause of stroke at
molecular level has been going on. A lot of advancement has occurred
in the prevention and treatment of stroke during the past decade. In
this review an update work of causeways of stroke and its therapeutic
approaches have been discussed. The relevance of excitotoxicity (role
of glutamate receptor), inflammation, ischemic penumbra, apoptosis,
to delayed mechanisms and, damage and treatment strategies have
been hasted out. Although the results among clinical studies, conflict
regarding several experimental data of different therapies, and it
may improve neurological outcome after acute cerebral ischemia.
Along this several other interventions and new technologies such
as stroke detector microwave helmet are being assessed and many
other advanced techniques developed by researchers. Even the
development of other novel and new treatment strategies (regarding
molecular pathways and risk to benefit therapeutic ratio) for stroke
are still required in future for better treatment.