Cost-effectiveness of Clozapine Compared With Conventional Antipsychotic Medication for Patients in State Hospitals

Essock, Susan M.; Frisman, Linda K.; Covell, Nancy H.; Hargreaves, William A.

doi:10.1001/archpsyc.57.10.987

Cited by 83 publications

(70 citation statements)

References 26 publications

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“…These have used a range of study designs such as controlled and uncontrolled cohorts 117,126,[129][130][131][132][133][134][135][136][137][138][139][140][141][142] and controlled trials. 73,[143][144][145][146][147][148][149][150][151][152] A large number of modelling studies has been published, based on data from a variety of sources. For the majority of these modelling studies it was not possible to verify the source or quality of the clinical or economic data.…”

Section: The Economics Of Schizophreniamentioning

confidence: 99%

“…32,33,[153][154][155][156][157][158][159][160] However, most of the studies have been limited in scale and methodology. Particular issues of concern are first, that with the exception of RCTs, 73,[143][144][145][146][147]149,151,152 most of the studies do not use clear and adequate methods to control bias. Second, for most of the studies the sources of data and methods of data collection were potentially weak.…”

Section: The Economics Of Schizophreniamentioning

confidence: 99%

“…126,131,151,162,163 Other economic evaluations found that clozapine was associated with a relatively small net cost, but was costeffective on one or more measures of outcome. 33,145 The systematic review and model by Bagnall and colleagues found that clozapine was associated with higher costs and similar or no difference in quality-adjusted outcomes compared with chlorpromazine, but was relatively cost-effective compared with haloperidol and other atypical antipsychotics. 32 In this study, clozapine was found to have a cost per QALY gained of less than £10,000 compared with ziprasidone, risperidone and amisulpride, a cost per QALY gained of less than £20,000 compared with olanzapine, and a cost per QALY gained of less than £40,000 when compared with zotepine.…”

Section: The Economics Of Schizophreniamentioning

confidence: 99%

See 2 more Smart Citations

Randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment

Lewis

Davies²,

Jones³

et al. 2006

Health Technol Assess

134

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. Declared competing interests of authors: SW Lewis received support for travel to meetings and honoraria for consultancies from AstraZeneca, Lilly, BristolMyersSquibb, Pfizer, Janssen, Wyeth, Lundbeck, GlaxoSmithKline and Novartis. L Davies received funding for preparing papers and attendance at meetings from Janssen, Hoechst Marion Roussel, Pfizer, AstraZeneca and Lundbeck, and project funding from Novartis. PB Jones received travel support to academic meetings from companies manufacturing drugs used in this study, and unrestricted use of honoraria and consultancy fees for some work for academic use in his department and elsewhere. TRE Barnes received travel support to academic meetings and honoraria for consultancy from companies manufacturing drugs used in this study, plus the award of a grant from Sanofi-Synthelabo for an investigator-initiated study. RM Murray received honoraria and advisory fees from pharmaceutical companies (paid into departmental research funds). R Kerwin received honoraria and advisory fees from pharmaceutical companies and received research grants for non-clinical research from Novartis. D Taylor received honoraria for a lecture and consultancy from manufacturers of atypical antipsy...

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Section: The Economics Of Schizophreniamentioning

confidence: 99%

Section: The Economics Of Schizophreniamentioning

confidence: 99%

Section: The Economics Of Schizophreniamentioning

confidence: 99%

See 1 more Smart Citation

Randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment

Lewis

Davies²,

Jones³

et al. 2006

Health Technol Assess

134

View full text Add to dashboard Cite

show abstract

“…Clozapine was compared with conventional treatment in two studies (Essock 2000, 335 Rosenheck 1998 115 ).…”

Section: Chapter 13mentioning

confidence: 99%

A systematic review of atypical antipsychotic drugs in schizophrenia

Bagnall

Jones

Ginnelly

et al. 2003

Health Technol Assess

151

114

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTAA systematic review of atypical antipsychotic drugs in schizophrenia NHS R&D HTA ProgrammeT he NHS R&D Health Technology Assessment (HTA) Programme was set up in 1993 to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS.The research reported in this monograph was commissioned by the HTA Programme on behalf of the National Institute for Clinical Excellence (NICE). Technology assessment reports are completed in a limited time to inform the appraisal and guidance development processes managed by NICE. The review brings together evidence on key aspects of the use of the technology concerned. However, appraisals and guidance produced by NICE are informed by a wide range of sources.The research reported in this monograph was funded as project number 00/20/01.The views expressed in this publication are those of the authors and not necessarily those of the HTA Programme, NICE or the Department of Health. The editors wish to emphasise that funding and publication of this research by the NHS should not be taken as implicit support for any recommendations made by the authors. Criteria for inclusion in the HTA monograph seriesReports are published in the HTA monograph series if (1) they have resulted from work commissioned for the HTA Programme, and (2) they are of a sufficiently high scientific quality as assessed by the referees and editors.Reviews in Health Technology Assessment are termed 'syst...

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“…No long-term effectiveness study has compared olanzapine or any of the other atypical antipsychotics except clozapine, 21,22 whose use is quite restricted, with a conventional drug. Although olanzapine is more expensive than conventional agents (costing Ͼ$4000 more annually at wholesale prices 6 ), if it yields equivalent savings in other health costs, these expenditures would be justified.…”

mentioning

confidence: 99%

Effectiveness and Cost of Olanzapine and Haloperidol in the Treatment of Schizophrenia<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

Rosenheck

Perlick

Bingham³

et al. 2003

JAMA

314

171

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Cost-effectiveness of Clozapine Compared With Conventional Antipsychotic Medication for Patients in State Hospitals

Abstract: Clozapine demonstrated cost-effectiveness on some but not all measures of effectiveness when the alternative was a range of conventional antipsychotic medications.

Cited by 83 publications

References 26 publications

Randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment

Randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment

A systematic review of atypical antipsychotic drugs in schizophrenia

Effectiveness and Cost of Olanzapine and Haloperidol in the Treatment of Schizophrenia<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

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