Cost-Effectiveness of Antiviral Therapy in Treatment-Naive Patients With Chronic Hepatitis C (Genotype 1)  With Various Severity of Fibrosis Stage

Рудакова, А. В.; Гусев, Д. А.; Усков, А. Н.; Shestakova, I.; Lobzin, Yu. V.

doi:10.22625/2072-6732-2017-9-4-93-101

Cited by 3 publications

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References 3 publications

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“…However, the available data on the prevalence of viral hepatitis in the countries of origin (Uzbekistan and Tajikistan) suggest high rates of infection [29]. The data vary, but the frequency of hepatitis C detection in the native population of Russia is between 1 to 2.4% [30]. The data reported in different studies on viral hepatitis prevalence among migrants from the former Soviet Union countries in Russia are summarized in Table 3.…”

Section: Viral Hepatitismentioning

confidence: 99%

Health of refugees and migrants from former Soviet Union countries in the Russian Federation: a narrative review

Bakunina

Gil

Polushkin³

et al. 2020

Int J Equity Health

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This narrative review was conducted to synthesize and summarize available up-to-date evidence on current health status, including both non-communicable diseases and infectious diseases, of migrants and refugees from the former Soviet Union countries in the Russian Federation. Epidemiological and sociological studies with one or more determinants of the health, as well as relevant qualitative studies characterizing risk factors, well-being indicators, and lifestyles of migrants and refugees from the former Soviet Union countries in Russia published from 2004 to 2019 in Russian and English languages were included in the review. Despite significant limitations of the available research literature in the field, some patterns in migrants’ health in Russia and issues that need to be addressed were identified. In particular, the syndemic epidemics of communicable and non-communicable diseases, additively increasing negative health consequences, including cardiovascular diseases and chronic digestive system diseases, high rates of sexually transmitted infections and HIV, respiratory diseases and a growing percentage of new tuberculosis cases among migrants from the former Soviet Union countries are all of great concern. Possibly, the burden of these co-occurring morbidities is linked to commonly reported issues among this population group, such as poor nutrition and living conditions, high prevalence of unskilled manual labour, non-compliance with sanitary norms, lack of basic vaccinations, lack of basic knowledge about safe sexual practices and risky sexual behaviour, low healthcare seeking behaviour and limited access to health care. Importantly, these findings may urge the government to increase efforts and promote international collaboration in combating the threat of infectious diseases. Additionally, it was found that migrants had higher levels of anxiety and post-traumatic stress disorder, and those who stayed in the receiving country 5 years or more had a higher level of somatic pathology than those whose stay was less than 5 years. In order to ensure an adequate health system response and fulfil the main Universal Health Coverage principle of “leaving no one behind”, a robust monitoring system of the health status of refugees and migrants and an integrated legal framework for the standardized and more inclusive routine care for this population in Russia is urgently needed.

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Section: Viral Hepatitismentioning

confidence: 99%

Health of refugees and migrants from former Soviet Union countries in the Russian Federation: a narrative review

Bakunina

Gil

Polushkin³

et al. 2020

Int J Equity Health

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Women Co-Infected With Hiv and Vhc. Part 2. Clinical Status and Readiness to Antiviral Therapy

Belyakov

Rassokhin

Боева

et al. 2019

VIČ-infekc. immunosupr.

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The materials on psychological and psychosocial status of women with HIV and HCV co-infection [1] with the following assessment of their readiness and ability to undergo treatment of chronic hepatitis C virus and maintenance of treatment compliance to antiretroviral therapy of HIV. The objective of the survey: analysis of the clinical and somatic status of women with HIV and HCV co-infection with the following assessment of their ability to antiviral therapy of CHC and maintenance of treatment compliance to ART taking into account their health status. Materials and methods: the check-up of 100 surveyed women with HIV and HCV co-infection taking into account epidemiologic evidence, laboratory parameters: immunologic (CD4 lymphocyte count), virological (HIV and VHC RNA, VHC genotype) and complete and biochemical blood count was made. Medical prescriptions and response to treatment of CHC were analyzed taking into account the drugs used. Results. Mean age of patients was 36±6 years. Most women had a long-standing co-infection. 1% of women were in the subclinical stage of HIV infection, 64% had stage 4A, 4B — 14% and 4B — 11%. The number of CD4 lymphocytes was 494±29 cells/μl. 78% received ART, and 85% of women showed a high rate of treatment compliance. Among the prevalent HIV-associated diseases were candidiasis (62%), viral (7%) and bacterial diseases (3%); a high percentage (15%) of past tuberculosis of various localization was noted. In 45 cases (53%), HCV RNA was detected in the blood. According to the results of liver elastometry, 74,4% had minimal and moderate fibrosis (METAVIR ≤F2), and a quarter of patients had marked fibrosis (METAVIR F3-F4). Antiviral therapy of chronic hepatitis C was performed in 24% of 100 surveyed women. 62,5% received the combination of pegylated interferon and ribavirin, in 86,6% of cases a sustained virological response was achieved. Treatment with direct antiviral agents was performed in 5 patients, in all cases a sustained virological response was achieved. 85% of patients showed total bilirubin level within the normal range, alanine aminotransferase and aspartate aminotransferase were moderately increased in 41% of women. Most (67,7%) revealed diffuse changes in the structure of the liver, and 36% had pancreatic diffuse changes. Hepatomegaly was found in 24% of cases and splenomegaly was found in 13,3% of women. Comorbid infectious and non-infectious diseases were diagnosed in 59% of women: 32,2% — diseases of the digestive system, 20,3% — diseases of the urogenital system and 18,6% — diseases of the respiratory system. Diseases of the nervous system were diagnosed in 70% of women. Conclusion. The somatic state of women with HIV/HCV co-infection in almost all cases was quite stable, the comorbid pathology was in remission, which gives grounds for expanding indications for prescribing antiviral therapy for CHC. However, many patients are not inclined to undergo treatment with interferon-containing regimens due to the duration of the course and poor tolerance, some of them are focused on treatment with direct-acting antiviral agents and are looking for such a possibility outside the hospital. Therapy with direct-acting antiviral agents with a small number of side effects and high efficacy is a priority for women with HIV/HCV co-infection.

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State and prospects of therapeutic treatment of children with chronic hepatitis C in the Russian Federation

Fomicheva¹,

Мамонова²,

Pimenov³

et al. 2021

jour

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Aim. To determine the number of children with chronic hepatitis C in the Russian Federation, including, who have received antiviral treatment, taking into account their age, the genotype of the virus, as well as the therapy regimens used.Materials and methods. The analysis of specially developed statistical reporting forms was carried out, the filling of which was carried out in September 2020 by specialists from 268 medical organizations from 37 constituent entities of the Russian Federation, which are part of 8 federal districts.Results. In September 2020, 2,160 children with chronic hepatitis C virus infection aged 0 to 17 years were under observation in 268 medical organizations, including 50.7% females and 49.3% of males. The number of children in the age group from 12 to 17 years was 42.9%, from 6 to 11 years – 34.5%, from 3 to 5 years – 16.2% and from 0 to 2 years – 6.4%. The genotype of the virus was determined in 1388 (64.3%) children. The proportion of children with genotype 1 was 58.6%, with genotype 3 – 37.2%, with genotype 2 – 4%. Only 141 (8.8%) children with chronic hepatitis C virus infection have been received antiviral therapy. 1465 (91.2%) children were not treated, but 153 (9.5%) of them received therapy earlier, without achieving a sustained virological response. Direct-acting antiviral agents treatment was carried out to 120 children (85.1%), of whom glecaprevir + pibrentasvir was received by 85 children (70.8%) in 20 regions, sofosbuvir + ledipasvir – 14 children (11.7%) in 6 regions, sofosbuvir – 14 children (11.7%) in 6 regions, daklatasvir – 7 children (5.8%) in 4 regions. Children are removed from dispensary observation after achieving a stable virological response in accordance with the current regulatory documents in 26 regions of the Russian Federation (70.3%).Conclusion. In 2020, less than 10% of children under management received antiviral therapy for chronic hepatitis C virus infection in the Russian Federation. It is necessary to approve the state program for the treatment of viral hepatitis, one of the directions of which should be the provision of all children with chronic hepatitis C virus infection with modern highly effective antiviral drugs. It is also necessary to conduct clinical trials to assess the safety and efficacy of direct-acting antiviral agents for children with chronic hepatitis C virus infection in order to ensure the possibility of their earlier prescription.

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Cost-Effectiveness of Antiviral Therapy in Treatment-Naive Patients With Chronic Hepatitis C (Genotype 1) With Various Severity of Fibrosis Stage

Abstract: Резюме Терапия хронического гепатита С (ХГС) с примене-нием безинтерфероновых схем является высокоэффек-

Cited by 3 publications

References 3 publications

Health of refugees and migrants from former Soviet Union countries in the Russian Federation: a narrative review

Health of refugees and migrants from former Soviet Union countries in the Russian Federation: a narrative review

Women Co-Infected With Hiv and Vhc. Part 2. Clinical Status and Readiness to Antiviral Therapy

State and prospects of therapeutic treatment of children with chronic hepatitis C in the Russian Federation

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