Cost-effectiveness of Anti-VEGF treatments for age-related macular degeneration: a
            Brazilian perspective

Nunes, Renata Portella; Hirai, Flávio E.; Rodrigues, Eduardo B.; Farah, Michel Eid

doi:10.5935/0004-2749.20200020

Cited by 4 publications

(3 citation statements)

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“…In our study, patients with fluid in the macular region and loss of VA were referred to local treatment with Anti-VEGF injections. In the Brazilian Health System, Bevacizumab is more easily available than Ranibizumab or Aflibercept due to its lower cost [ 15 ]. In the study, only 1/3 of patients have received intravitreal treatment and have shown mixed outcomes regarding VA and fluid reabsorbation.…”

Section: Discussionmentioning

confidence: 99%

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Ocular metastases profile in a tertiary hospital in São Paulo, Brazil

Ogata,

Ferreira,

Morales

et al. 2024

Int J Retin Vitr

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Objective Ocular metastases are the most common intraocular tumours in adults. Data regarding the occurrence of these tumours in the Brazilian population is scarce. We aimed to investigate the profile of ocular metastases of patients referred to tertiary hospital service in São Paulo, Brazil. Design Retrospective study. Participants Patients referred to the Ocular Oncology service of the Federal University of São Paulo with initial diagnostic hypothesis of ocular metastasis. Methods Data was retrospectively collected from medical records from June 2017 to June 2023. Age, sex, primary tumour site, previous knowledge of the systemic diagnosis, laterality, initial visual acuity (VA), local or systemic treatment and mean follow-up period were obtained. Results A total of 37 cases were referred to the ocular oncology division due to a suspected ocular metastasis, 15 (40.5%) were confirmed. Mean age at diagnosis was 53.47 ± 16.01 years old, the majority (86.7%) of patients already knew the systemic diagnosis. Breast cancer (66.7%) was the most common primary site, followed by Lung cancer (26.7%). Both eyes were affected in 66.67% of the cases, all patients had metastases at the choroid (100.0%), and the mean initial VA was 1.37 ± 1.04 logMAR. Chemotherapy was the main systemic treatment modality (73.3%), and most patients had no ocular treatment (53.3%). The mortality rate along the follow-up period was 30.0%. Conclusions Considering the number of new patients absorbed by the Ocular Oncology service over the study period, the frequency of ocular metastases was relatively low. The patients’ characteristics was comparable to data published in the international literature.

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Section: Discussionmentioning

confidence: 99%

“…Life expectancy is hard to quantify in choroidal metastasis patients and mortality in these patients correlates with the presence of synchronous lesions in the liver or lungs [12][13][14][15][16][17]. The study followed the patients in an average of 14.8 months and the survival rates were considerably high in this period.…”

Section: Discussionmentioning

confidence: 99%

Ocular metastases profile in a tertiary hospital in São Paulo, Brazil

Ogata,

Ferreira,

Morales

et al. 2024

Int J Retin Vitr

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“…Por fim, o BEZ apresenta menor custo unitário em relação ao RAZ e AFC e, por esse motivo, diferentes autores confirmaram que esta é a opção com melhor custo-efetividade para o tratamento da DMRI-n 4,13,22,23 .…”

Section: Métodosunclassified

Protocolo assistencial de injeções intravítreas do HCPA: degeneração macular relacionada com a idade na forma neovascular

Scheid¹,

Falavigna²,

Lavinsky³

et al. 2021

CBR

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A degeneração macular relacionada com a idade na forma neovascular é uma das principais causas de cegueira no mundo e a segunda indicação mais frequente de injeções intravítreas no Hospital de Clínicas de Porto Alegre. O tratamento com injeção intra-vítrea de medicamentos supressores do fator de crescimento endotelial (anti-vascular endothelial growth factor, anti-VEGF), incluindo o bevacizumabe, revolucionou o desfecho visual destes pacientes às custas de múltiplas aplicações mensais. Assim como em outros centros, discrepâncias entre condutas da equipe assistencial e dificuldades logísticas acabam comprometendo a efetividade do tratamento. Portanto, desenvolvemos um protocolo de tratamento para a DMRI-n embasado na literatura, estabelecendo critérios de inclusão, exclusão, regime de tratamento e seguimento do paciente. Com isto, esperamos otimizar a efetividade e assistência do paciente com DMRI-n.

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Progress in the Treatment of Dry Age-Related Macular Degeneration

刘¹

2020

ACM

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Cost-effectiveness of Anti-VEGF treatments for age-related macular degeneration: a Brazilian perspective

Cited by 4 publications

References 0 publications

Ocular metastases profile in a tertiary hospital in São Paulo, Brazil

Ocular metastases profile in a tertiary hospital in São Paulo, Brazil

Protocolo assistencial de injeções intravítreas do HCPA: degeneração macular relacionada com a idade na forma neovascular

Progress in the Treatment of Dry Age-Related Macular Degeneration

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