Cost-effectiveness of Anbainuo plus methotrexate compared to conventional disease-modifying antirheumatic drugs for rheumatoid arthritis patients in China

Tian, Feng; Wen, Zhenhua; Li, Jingyang; Luo, Xiao-Wen; Deng, Li; Zhang, Liang; He, Jingyun; Yao, Fangling; Liao, Zihao

doi:10.21037/atm-21-3132

Cited by 3 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Part of researches also would include sociodemographic or clinical characteristics as covariates. Interestingly, some of the CUA conducted on Chinese RA patients chose to use the mapping algorithm developed on Spanish populations ( 19 , 22 – 24 ), although the mapping algorithms based on Chinese populations were available ( 13 ). Now, two researches have developed the mapping algorithms from HAQ-DI to EQ-5D-5L based on Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Mapping health assessment questionnaire disability index onto EQ-5D-5L in China

Wan

Wang

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

ObjectiveThis research aimed to develop the more accurate mapping algorithms from health assessment questionnaire disability index (HAQ-DI) onto EQ-5D-5L based on Chinese Rheumatoid Arthritis patients.MethodsThe cross-sectional data of Chinese RA patients from 8 tertiary hospitals across four provincial capitals was used for constructing the mapping algorithms. Direct mapping using Ordinary least squares regression (OLS), the general linear regression model (GLM), MM-estimator model (MM), Tobit regression model (Tobit), Beta regression model (Beta) and the adjusted limited dependent variable mixture model (ALDVMM) and response mapping using Multivariate Ordered Probit regression model (MV-Probit) were carried out. HAQ-DI score, age, gender, BMI, DAS28-ESR and PtAAP were included as the explanatory variables. The bootstrap was used for validation of mapping algorithms. The average ranking of mean absolute error (MAE), root mean square error (RMSE), adjusted R2 (adjR2) and concordance correlation coefficient (CCC) were used to assess the predictive ability of the mapping algorithms.ResultsAccording to the average ranking of MAE, RMSE, adjR2, and CCC, the mapping algorithm based on Beta performed the best. The mapping algorithm would perform better as the number of variables increasing.ConclusionThe mapping algorithms provided in this research can help researchers to obtain the health utility values more accurately. Researchers can choose the mapping algorithms under different combinations of variables based on the actual data.

show abstract

Section: Introductionmentioning

confidence: 99%

Mapping health assessment questionnaire disability index onto EQ-5D-5L in China

Wan

Wang

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

Cost-effectiveness of tumor necrosis factor-alpha inhibitors: a systematic review and meta-analysis of cost-utility studies

Kumar,

Bagepally

2023

Expert Review of Pharmacoeconomics & Outcomes Research

View full text Add to dashboard Cite

RETRACTED ARTICLE: Dehydroevodiamine suppresses inflammatory responses in adjuvant-induced arthritis rats and human fibroblast-like synoviocytes

Dai

Sheng

et al. 2021

Bioengineered

View full text Add to dashboard Cite

Dehydroevodiamine (DHE) is an effective natural active substance extracted from Euodiae Fructus , which is a widely used herbal drug in traditional Chinese medicine. The focus of this study was to test the possibility of using DHE in the treatment of rheumatoid arthritis (RA) diseases. A rat model of adjuvant-induced arthritis (AIA) was generated using Complete Freund’s Adjuvant (CFA). Body weight changes, arthritis scores, ankle pathology, tumor necrosis factor-alpha (TNF-α), interleukin-1β(IL-1β), interleukin-6 (IL-6), and interleukin-17 (IL-17) secretion, as well as matrix metalloproteinase (MMP) expression in joint tissue, were measured as indicators of viability of DHE medicated AIA rats. Human fibroblast-like synoviocytes (MH7A cells) were connected to check these impacts. The results confirmed that DHE administration had an excellent therapeutic impact on the AIA rat model, substantially relieving joint swelling, inhibiting synovial pannus hyperplasia, and decreasing joint scores. In addition, the serum enzyme-linked immunosorbent assay (ELISA) showed that DHE treatment reduced the expression of pro-inflammatory factors in AIA rats. The immunohistochemical results showed that DHE treatment could reduce the synthesis of MMPs such as matrix metalloproteinase-1(MMP-1) and matrix metalloproteinase-3 (MMP-3) in the ankle tissue of AIA rats. In vitro, DHE inhibited cell proliferation, mRNA transcription, protein synthesis of proinflammatory factors such as IL-1βand IL-6, and matrix metalloproteinases such as MMP-1 and MMP-3. Furthermore, DHE inhibited the phosphorylation levels of p38, JNK, and ERK proteins in TNF-α-treated MH7A cells.This work assessed the effect of DHE in AIA rats and revealed its mechanism in vitro.

show abstract

Cost-effectiveness of Anbainuo plus methotrexate compared to conventional disease-modifying antirheumatic drugs for rheumatoid arthritis patients in China

Cited by 3 publications

References 21 publications

Mapping health assessment questionnaire disability index onto EQ-5D-5L in China

Mapping health assessment questionnaire disability index onto EQ-5D-5L in China

Cost-effectiveness of tumor necrosis factor-alpha inhibitors: a systematic review and meta-analysis of cost-utility studies

RETRACTED ARTICLE: Dehydroevodiamine suppresses inflammatory responses in adjuvant-induced arthritis rats and human fibroblast-like synoviocytes

Contact Info

Product

Resources

About