Cost-effectiveness of a potential group B streptococcal vaccine program for pregnant women in South Africa

Kim, Sun Young; Russell, Louise B.; Park, Jeehyun; Verani, Jennifer R.; Madhi, Shabir А.; Cutland, Clare; Schrag, Stephanie J.; Sinha, Anushua

doi:10.1016/j.vaccine.2014.01.062

Cited by 58 publications

(73 citation statements)

References 29 publications

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“…Intrapartum antibiotic prophylaxis would reduce the incidence of early-onset GBS infection by 65%, while also reducing the severity of late-onset disease (Ko et al, 2010). A GBS vaccine is likely to be the most effective preventive strategy, both in pregnant women and newborns (Kim et al, 2014). A GBS polysaccharide-protein conjugate vaccine has completed phase two of a trial in South Africa, and has been shown to prevent both early-and late-onset infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis

et al. 2016

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ABSTRACT. With the advent of antibiotic resistance, pathogenic bacteria have become a major threat in cases of neonatal sepsis; however, guidelines for treatment have not yet been standardized. In this study, 15 cases of neonatal Streptococcus agalactiae sepsis from our hospital were retrospectively analyzed. Of these, nine cases showed early-onset and six cases showed late-onset sepsis. Pathogens were characterized by genotyping and antibiotic sensitivity tests on blood cultures. Results demonstrated that in cases with early-onset sepsis, clinical manifestations affected mainly the respiratory tract, while lateonset sepsis was accompanied by intracranial infection. Therefore, we suggest including a cerebrospinal fluid examination when diagnosing neonatal sepsis. Bacterial genotyping indicated the bacteria were mainly type Ib, Ia, and III S. agalactiae. We recommend treatment with penicillin or ampicillin, since bacteria were resistant to clindamycin and tetracycline. In conclusion, our results provide valuable information for the clinical treatment of S. agalactiae sepsis in neonatal infants.

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Section: Discussionmentioning

confidence: 99%

Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis

et al. 2016

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“…On the other hand, as a consequence of vaccinations in older age, teenage girls will not be covered by the program of vaccinations. Therefore, some authors propose a combination of GBS vaccination with the alreadyused prophylactic procedures recommended by CDC as the most effective in terms of health and costs [31].…”

Section: Discussionmentioning

confidence: 99%

Demographic conditioning of awareness of prophylaxis against Streptococcus agalactiae (GBS) infections among parturients

Bąk¹,

Sikorski²,

Woźniak³

2016

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Introduction: Infection with Streptococcus agalactiae (group B Streptococcus -GBS) is a frequent cause of serious complications in the neonatal period. Circa 10-30% of pregnant women are carriers of this streptococcus. Current prophylaxis of GBS infections is an elementary way of defining whether there is a risk of the child's infection. The achieved research result determines further perinatal proceedings. Aim of the research:To determine how such factors as age, residence, education, and current women's parity influence their awareness concerning prophylaxis of infections with Streptococcus agalactiae. The research also analysed women's knowledge of threats to their health related to the presence of GBS infections. Material and methods: Analysis of 164 author's questionnaires completed by women giving birth at the labour ward in the early delivery stage. The results were analysed in view of statistical accordance of measurable qualities by means of c 2 test. For statistical conclusions, the significance level of p < 0.05 was adopted. Results and conclusions: Older pregnant women in comparison with the younger ones more frequently realise the importance of the GBS prophylaxis. Women from the urban environment have greater awareness of the GBS prophylaxis than women from the rural environment. An increase in the level of education is related to an increase in the GBS prophylaxis awareness. Women in their first pregnancy have a greater knowledge of the standards of pregnancy proceedings connected with GBS than women who have already given birth to a child.

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“…A decision-analytic model based on South African data concluded that immunization alone would substantially reduce the burden of infant GBS disease in South Africa and would be very cost-effective by WHO guidelines 167 .…”

Section: F Cost-effectiveness Of Immunizationmentioning

confidence: 99%