Cost‐effectiveness analysis of hepatitis E vaccination strategies among patients with chronic hepatitis B in China

Cui, Tingting; Zhang, Xuefeng; Wang, Qiang; Yue, Na; Bao, Changjun; Jiang, Renjie; Xu, Shilin; Yuan, Zhaohu; Qian, Yunke; Chen, Liling; Hang, Hui; Zhang, Zhong; Sun, Hongmin; Jin, Hui

doi:10.1111/hepr.13967

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…A prospective study found that pregnant women infected with HEV have worse outcomes than those with acute viral hepatitis caused by other hepatitis viruses ( 5 ). In immunocompromised individuals and those with concomitant chronic hepatitis B infection, HEV infection often imposes a greater burden with a significantly longer course, higher economic burden, and greater resultant health loss ( 6 ). The prevention and control of hepatitis E (HE) is a major public health issue ( 7–10 ).…”

Section: Introductionmentioning

confidence: 99%

Spatial-temporal analysis of hepatitis E in Hainan Province, China (2013-2022): insights from four major hospitals

Yun,

Li,

Wang

et al. 2024

Front. Public Health

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ObjectiveExploring the Incidence, Epidemic Trends, and Spatial Distribution Characteristics of Sporadic Hepatitis E in Hainan Province from 2013 to 2022 through four major tertiary hospitals in the Province.MethodsWe collected data on confirmed cases of hepatitis E in Hainan residents admitted to the four major tertiary hospitals in Haikou City from January 2013 to December 2022. We used SPSS software to analyze the correlation between incidence rate and economy, population density and geographical location, and origin software to draw a scatter chart and SAS 9.4 software to conduct a descriptive analysis of the time trend. The distribution was analyzed using ArcMap 10.8 software (spatial autocorrelation analysis, hotspot identification, concentration, and dispersion trend analysis). SAS software was used to build an autoregressive integrated moving average model (ARIMA) to predict the monthly number of cases in 2023 and 2024.ResultsFrom 2013 to 2022, 1,922 patients with sporadic hepatitis E were treated in the four hospitals of Hainan Province. The highest proportion of patients (n = 555, 28.88%) were aged 50–59 years. The annual incidence of hepatitis E increased from 2013 to 2019, with a slight decrease in 2020 and 2021 and an increase in 2022. The highest number of cases was reported in Haikou, followed by Dongfang and Danzhou. We found that there was a correlation between the economy, population density, latitude, and the number of cases, with the correlation coefficient |r| value fluctuating between 0.403 and 0.421, indicating a linear correlation. At the same time, a scatter plot shows the correlation between population density and incidence from 2013 to 2022, with r2 values fluctuating between 0.5405 and 0.7116, indicating a linear correlation. Global Moran’s I, calculated through spatial autocorrelation analysis, showed that each year from 2013 to 2022 all had a Moran’s I value >0, indicating positive spatial autocorrelation (p < 0.01). Local Moran’s I analysis revealed that from 2013 to 2022, local hotspots were mainly concentrated in the northern part of Hainan Province, with Haikou, Wenchang, Ding’an, and Chengmai being frequent hotspot regions, whereas Baoting, Qiongzhong, and Ledong were frequent cold-spot regions. Concentration and dispersion analysis indicated a clear directional pattern in the average density distribution, moving from northeast to southwest. Time-series forecast modeling showed that the forecast number of newly reported cases per month remained relatively stable in 2023 and 2024, fluctuating between 17 and 19.ConclusionThe overall incidence of hepatitis E in Hainan Province remains relatively stable. The incidence of hepatitis E in Hainan Province increased from 2013 to 2019, with a higher clustering of cases in the northeast region and a gradual spread toward the southwest over time. The ARIMA model predicted a relatively stable number of new cases each month in 2023 and 2024.

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Section: Introductionmentioning

confidence: 99%

Spatial-temporal analysis of hepatitis E in Hainan Province, China (2013-2022): insights from four major hospitals

Yun,

Li,

Wang

et al. 2024

Front. Public Health

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“…[15][16][17][18] In this issue of Hepatology Research, Cui et al evaluated the cost-effectiveness of hepatitis E vaccination strategies in Chinese patients with CHB. 19 Cost-effectiveness of three hepatitis E vaccination strategies: vaccination without screening, screening-based 122 -Hepatology Research. 2024;54:122-124. wileyonlinelibrary.com/journal/hepr © 2023 The Japan Society of Hepatology.…”

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confidence: 99%

Cost‐effectiveness of hepatitis E virus vaccination strategy

Kato

2023

Hepatology Research

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Hepatitis E is a leading cause of acute viral hepatitis worldwide and the infection is usually asymptomatic or self-limiting. According to WHO data, it is estimated that 20 million hepatitis E virus (HEV) infections occur worldwide every year and leading to a 3.3 million symptomatic cases of hepatitis E. 1 Hepatitis E caused approximately forty-four thousands deaths in 2015 (accounting for 3.3% of the mortality due to viral hepatitis). Hepatitis E virus is transmitted via the fecal-oral route, principally via contaminated water especially in developing countries. Hepatitis E is prevalent worldwide, and the disease is most common in East and South Asia. 1 Certain populations are at particular risk of developing serious consequences by HEV infection. Patients with advanced chronic liver strategies appropriate for each region, taking into account the HEV endemicity.

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Epidemiological assessment of hepatitis E virus infection among 1565 pregnant women in Siem Reap, Cambodia using an in‐house double antigen sandwich ELISA

Mirzaev,

Ko,

et al. 2024

Hepatology Research

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AimThis study investigated hepatitis E virus (HEV) prevalence among pregnant women in Siem Reap, Cambodia, by developing a cost‐effective, user‐friendly in‐house enzyme‐linked immunosorbent assay (ELISA) for detecting total anti‐HEV immunoglobulins (Ig).MethodsThe in‐house ELISA was designed for large‐scale screening in resource‐limited settings. Its performance was benchmarked against two commercial tests: the Anti‐HEV IgG EIA (Institute of Immunology, Co. Ltd) and the Anti‐HEV IgG RecomLine LIA (Mikrogen). The in‐house ELISA demonstrated a sensitivity of 76% and 71.4%, and a specificity of 94.1% and 98.6%, against the two commercial tests, respectively, with overall agreement rates of 92.4% and 94.3%.ResultsAmong 1565 tested pregnant women, 11.6% were anti‐HEV positive. Prevalence increased with age, particularly in women aged 35–40 years and over 40 years. No significant associations were found with education, number of children, family size, or history of blood transfusion and surgery, except for the occupation of the family head as a public officer. Of the total anti‐HEV positive women, 22.7% had anti‐HEV IgM, indicating recent or ongoing infection.ConclusionThe study concluded that the in‐house ELISA is a viable option for HEV screening in regions with limited resources due to its high accuracy and cost‐effectiveness. It is particularly suitable for large‐scale studies and public health interventions in areas where HEV is endemic and poses a significant risk to pregnant women.

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Cost‐effectiveness analysis of hepatitis E vaccination strategies among patients with chronic hepatitis B in China

Cited by 4 publications

References 39 publications

Spatial-temporal analysis of hepatitis E in Hainan Province, China (2013-2022): insights from four major hospitals

Spatial-temporal analysis of hepatitis E in Hainan Province, China (2013-2022): insights from four major hospitals

Cost‐effectiveness of hepatitis E virus vaccination strategy

Epidemiological assessment of hepatitis E virus infection among 1565 pregnant women in Siem Reap, Cambodia using an in‐house double antigen sandwich ELISA

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