Cost-effectiveness analysis of different COVID-19 screening strategies based on rapid or laboratory-based SARS-CoV-2 antigen testing

Pighi, Laura; Henry, Brandon Michael; Mattiuzzi, Camilla; Nitto, Simone De; Salvagno, Gian Luca; Lippi, Giuseppe

doi:10.1515/cclm-2023-0164

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…In low- and middle-income countries, swab-based COVID-19 PCR testing costs more than US $200, while saliva-based testing approaches are comparatively less costly [ 38 ]. A cost-effectiveness analysis of different COVID-19 screening strategies based on rapid or laboratory-based SARS-CoV-2 antigen testing found that in situations where test sensitivity is of paramount importance, nucleic acid amplification tests are preferred [ 39 ]. Low and middle-income countries have been pledged 120 million COVID-19 diagnostic tests, which can provide results in 15 to 30 min, with the price set at US $5 per unit and the expectation that the cost will decrease [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, and High-Income Countries: A Systematic Review

Purba,

Rosyid,

Handayani

et al. 2024

Med Sci Monit

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Background Economic evaluation of the testing strategies to control transmission and monitor the severity of COVID-19 after the pandemic is essential. This study aimed to review the economic evaluation of COVID-19 tests and to construct a model with outcomes in terms of cost and test acceptability for surveillance in the post-pandemic period in low-income, middle-income, and high-income countries. Material/Methods We performed the systematic review following PRISMA guidelines through MEDLINE and EMBASE databases. We included the relevant studies that reported the economic evaluation of COVID-19 tests for surveillance. Also, we input current probability, sensitivity, and specificity for COVID-19 surveillance in the post-pandemic period. Results A total of 104 articles met the eligibility criteria, and 8 articles were reviewed and assessed for quality. The specificity and sensitivity of COVID-19 screening tests were reported as 80% to 90% and 40% to 90%, respectively. The target population presented a mortality rate between 0.2% and 19.2% in the post-pandemic period. The implementation model of COVID-19 screening tests for surveillance with a cost mean for molecular and antigen tests was US$ 46.64 (min–max US $0.25–$105.39) and US $6.15 (min–max US $2–$10), respectively. Conclusions For the allocation budget for the COVID-19 surveillance test, it is essential to consider the incidence and mortality of the post-pandemic period in low-income, middle-income, and high-income countries. A robust method to evaluate outcomes is needed to prevent increasing COVID-19 incidents earlier.

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Section: Discussionmentioning

confidence: 99%

Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, and High-Income Countries: A Systematic Review

Purba,

Rosyid,

Handayani

et al. 2024

Med Sci Monit

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“…The implementation of novel rapid molecular tests may help to overcome the challenges described above, especially when patients' conditions require it. In addition, it has been demonstrated that strategies based on antigen (Ag) test, performed with laboratory equipment, coupled with real-time PCR testing in case of a first negative result offer better performances than Ag test alone, with a decreased cost with respect to real-time PCR alone [22] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a new molecular test for the detection of SARS-CoV-2 nucleic acid in salivary samples

et al. 2023

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Background: Molecular testing is considered the gold standard for the detection of SARS-CoV-2. This study aimed to compare the performance of the P742H SARS-CoV-2 Nucleic Acid Multiplex Detection Kit in salivary samples, with respect to the 732HF Novel Coronavirus (2019-nCoV) Nucleic Acid Detection Kit and the TaqPath COVID-19 CE-IVD RT-PCR Kit, used at University-Hospital of Padova, Italy. Methods: One hundred twenty-four salivary samples self-collected by healthcare workers (HCW) during the screening program at University-Hospital of Padova, Italy, from Oct to Nov 2022, were included in the study. RNA extraction was performed by Viral DNA and RNA Extraction Kit (Technogenetics, Lodi, Italy) and amplification by P742H and 732HF (Technogenetics, Lodi, Italy). RNA was extracted using MagNa Pure 96 DNA and Viral NA Small Volume Kit (Roche, Switzerland) for TaqPath analysis (Thermo Fisher Scientific, USA). Results: 94 samples were positive at P742H, while 30 were negative; for 732HF, 96 samples were positive, while 28 were negative, with an overall agreement of 97.5% (Cohen’s κ = 0.930, p < 0.001). TaqPath gave 95 positive samples, and 29 negative results, with an overall agreement of 100% (Cohen’s κ = 1.0, p < 0.001) with respect to P742H, and 97.5% (Cohen’s κ = 0.931, p < 0.001) with respect to 732HF. Comparing cycle threshold (Ct) between the P742H and 732HF, no statistically significant differences were found (p = n.s.). Conclusions: The P742H method proved better performances than 732HF for salivary samples, both presenting the same amplification time. In addition, P742H results were comparable to those obtained through the high-throughput method TaqPath.

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“…Nevertheless, as new rapid molecular testing technologies have become available, studies from high-resource countries, such as Germany, have shown promising results on the cost-effectiveness of such methods in emergency rooms and hospital settings [ 70 , 71 ]. Similarly, studies in Germany and Italy have also found economic benefits when using rapid antigen tests [ 72 , 73 ].…”

Section: The Role and Value Of Rapid Testing For The Management And T...mentioning

confidence: 99%

The Role and Value of Professional Rapid Testing of Acute Respiratory Infections (ARIs) in Europe: A Special Focus on the Czech Republic, Poland, and Romania

Drevinek,

Flisiak,

Nemes

et al. 2024

Diagnostics

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This review aims to explore the role of professional diagnostic rapid testing of acute respiratory infections (ARIs), especially COVID-19 and influenza, ensuring proper disease management and treatment in Europe, and particularly in Czech Republic, Poland, and Romania. The paper was constructed based on a review of scientific evidence and national and international policies and recommendations, as well as a process of validation by four experts. The development of new testing technologies, treatment options, and increased awareness of the negative multidimensional impact of ARI profiles transformed differential diagnosis into a tangible and desirable reality. This review covers the following topics: (1) the multidimensional impact of ARIs, (2) ARI rapid diagnostic testing platforms and their value, (3) the policy landscape, (4) challenges and barriers to implementation, and (5) a set of recommendations illustrating a path forward. The findings indicate that rapid diagnostic testing, including at the point of care (POC), can have a positive impact on case management, antimicrobial and antibiotic stewardship, epidemiological surveillance, and decision making. Integrating this strategy will require the commitment of governments and the international and academic communities, especially as we identified room for improvement in the access and expansion of POC rapid testing in the focus countries and the inclusion of rapid testing in relevant policies.

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Cost-effectiveness analysis of different COVID-19 screening strategies based on rapid or laboratory-based SARS-CoV-2 antigen testing

Cited by 10 publications

References 9 publications

Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, and High-Income Countries: A Systematic Review

Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, and High-Income Countries: A Systematic Review

Evaluation of a new molecular test for the detection of SARS-CoV-2 nucleic acid in salivary samples

The Role and Value of Professional Rapid Testing of Acute Respiratory Infections (ARIs) in Europe: A Special Focus on the Czech Republic, Poland, and Romania

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