Cost-Effectiveness Analysis of Carbapenems in Treatment Nosocomian Pneumonia in Ukraine

Abstract

Three additional sub-states: without exacerbation, mild and severe exacerbation were considered. The effectiveness of treatment options and utilities for each health state were taken from the literature. Only direct health care costs were considered. Disease management and exacerbation costs were obtained from the literature. Drug costs were calculated based on ex-factory prices with mandatory 7.5% rebate. All costs were updated to € 2012. A 3% annual discount rate on costs and health outcomes was applied. Incremental ratios in terms of cost per life-year gained (LYG) and cost per quality-adjusted life-year gained (QALY) of the most effective therapy versus the comparator were calculated. One-way sensitivity analyses were performed modifying the following parameters: time horizon (10 years, lifetime), discount rate (0%, 5%), drug costs (±10%, ±20%) and utilities (±10%). Probabilistic sensitivity analysis (PSA) was also performed. Results: At 5 years, glycopyrronium bromide accounted a total cost of € 2,225.18 compared to € 2,374.81 accounted for tiotropium bromide. Glycopyrronium bromide yielded higher health benefits (4,321 LYG and 3,388 QALY) than tiotropium bromide (4,315 LYG and 3,377 QALY). In all oneway sensitivity analyses performed and in 100% of PSA simulations (1,000 iterations), glycopyrronium bromide compared to tiotropium bromide remained as a dominant strategy. ConClusions: Glycopyrronium bromide therapy in COPD patients is associated to less costs and higher health benefits than tiotropium in Spain.

Impact and cost-effectiveness of non-governmental organizations on the HIV epidemic in Ukraine among MSM

“…The ICER per DALY averted for our study compares favourably with ICERs for other health interventions in Ukraine, particularly when considering this study’s ICER over a longer time horizon to 2050 (US$114). Other interventions in Ukraine with published ICERs include treatments for pneumonia (ICERs: US$910-1,317 per DALY averted)( 57 ) scaling up opioid agonist treatment among PWID and expanding ART among the general population (ICERs: US$530-2,240 per DALY averted)( 58 , 59 ) or antenatal testing with a dual rapid test for HIV and syphilis (varying from cost-saving to $205 per DALY averted)( 60 ).…”