Cost-Effectiveness Analysis of a HMGA2 Prognostic Test for Acute Myeloid Leukemia in a Canadian Setting

Abstract

BackgroundCurrent strategies for risk stratification of patients with acute myeloid leukemia assign approximately 40% of patients to the intermediate-risk group, where uncertainty about optimal therapy still persists.ObjectiveThe objective of this study was to assess the cost effectiveness of a HMGA2 prognostic test based on HMGA2+/HMGA2− expression, which improves genetic risk stratification in acute myeloid leukemia, and compare this test with the current standard of care in Canada.MethodsA cost-effectiveness model was developed from the Canadian National Healthcare Service and societal perspective using data from the Quebec Leukemia Cell Bank, published literature, and physician surveys. The model includes a lifetime horizon assessing the HMGA2 test vs. standard of care.ResultsThe HMGA2 test outperformed the standard of care at all time horizons culminating with estimated improvements of 1.92 and 3.12 months in leukemia-free survival and overall survival, respectively. Costs associated with the HMGA2 test were consistently lower, except diagnostic costs, routine medical costs, and costs related to infections and false positives. From a societal perspective, total lifetime costs were $161,358 CAD and $151,908 CAD with the standard of care and the HMGA2 test, respectively. The incremental quality-adjusted life-year gain was 0.138, which led to dominance over the standard of care. Deterministic sensitivity analyses confirmed the results of the base-case scenario. Probabilistic sensitivity analyses revealed that for a willingness-to-pay threshold of $100,000 CAD, the probability of cost effectiveness was 87.19%.ConclusionsThe HMGA2 test is estimated to improve leukemia-free survival and overall survival outcomes, and yield costs savings from a healthcare system and societal perspective.Electronic supplementary materialThe online version of this article (10.1007/s40258-019-00503-5) contains supplementary material, which is available to authorized users.

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“…Notably, a HMGA2 test based on qRT‐PCR analysis has been developed showing high reproducibility, specificity, and may represent also a potential cost reduction for AML diagnosis/prognosis processes. 60 Therefore, the high expression of HMGA2 may represent an important novel prognostic marker, complementing the current AML clinical and genetic prognostic factors.…”

“…DE MARTINO ET AL.significantly correlated with the probability of the treatment failure of the primary anthracycline and cytarabine therapies. Notably, a HMGA2 test based on qRT-PCR analysis has been developed showing high reproducibility, specificity, and may represent also a potential cost reduction for AML diagnosis/prognosis processes 60. Therefore, the high expression of HMGA2 may represent an important novel prognostic marker, complementing the current AML clinical and genetic prognostic factors.1.4.2 | HMGA genes in lymphocytic leukemiasLymphocytic leukemias may be divided in two main groups: acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL).…”

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“…This can reduce unnecessary treatments and can allow early scheduling of patients in first remission for allogeneic transplant, improving AML patients' leukemia-free survival and OS. All this not only leads to economic savings but also above all facilitates better patient management and disease outcomes [196].…”