Cost-effective smart microfluidic device with immobilized silver nanoparticles and embedded UV-light sources for synergistic water disinfection effects

Prabhakar, Amit; Agrawal, Mehul; Mishra, Neha; Roy, Nimisha; Jaiswar, Ankur; Dhwaj, Amar; Verma, Deepti

doi:10.1039/d0ra00076k

Cited by 6 publications

(3 citation statements)

References 19 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quite a few microfluidic biosensors modules may be directly interfaced with concurrent analyte samples via the proposed single impedance micropump for effective biosensing in an enclosed fluidic ambiance of microdevice and micropump. Owing to the easy manufacture procedure and its simple, cost-effective, minuscule, and closed modular blueprint, the projected micropump may be an efficient option as a peripheral pumping unit, for any lab-on-chip or in vitro BioMEMS application. − Further, we are continuously making efforts to convert the abovementioned micropump into a fully automated entity with a wider range of flow rates, while maintaining its compact size.…”

Section: Discussionmentioning

confidence: 99%

“…Owing to the easy manufacture procedure and its simple, cost-effective, minuscule, and closed modular blueprint, the projected micropump may be an efficient option as a peripheral pumping unit, for any lab-on-chip or in vitro BioMEMS application. 26 − 31 Further, we are continuously making efforts to convert the abovementioned micropump into a fully automated entity with a wider range of flow rates, while maintaining its compact size.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

3D-Printed Impedance Micropump for Continuous Perfusion of the Sample and Nutrient Medium Integrated with a Liver-On-Chip Prototype

et al. 2022

Self Cite

View full text Add to dashboard Cite

In recent decades, organ-on-chip devices have gained substantial interest as an alternative for studying the pathophysiological processes relevant to drug screening. Micropumps are being utilized to simulate the in vivo physiological fluid flow more realistically in these organ-on-chip devices. Micropumps play a crucial role in pumping, perfusion, and circulation of fluids in various microdevices such as on-chip PCR, DNA microarrays, miniature bioreactor cell separation, and lab-on-chip biosensing platforms. With the rapid growth in technology, efficient pumping for proper circulation of media and nutrients has become imperative. In this study, we have described the design and development of an open-source impedance micropump for continuous perfusion of nutrient medium in a liver-on-chip prototype. This micropump is controlled via an integrated microcontroller board, with an observed flow rate ranging from 0.2 to 2 mL/min. Google Sketchup 2020 and DLP 3D printing were used to fabricate small precise parts of the impedance micropump. The flow rate was measured to characterize the actuating performance of the micropump. The poly-dimethyl siloxane-based liver-onchip prototype has been fabricated using a soft photolithography procedure. Further, a study of continuous perfusion of culture medium through the liver-on-chip containing the Hepg2 cell line was successfully performed by integrating it with the impedance micropump. Hoechst staining and Alamar Blue observed cell viability to confirm the healthy cell growth inside the liver-on-chip microfluidic chip. The compactness of the overall setup allows it to fit in a Petri plate, eliminating chances of contamination while cell handling.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

3D-Printed Impedance Micropump for Continuous Perfusion of the Sample and Nutrient Medium Integrated with a Liver-On-Chip Prototype

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…To form Layer 1 and Layer 2 of the fabricated device, two SU-8 masters were created using a standard photolithographic process, [10][11][12][13] which provided a template for PDMS casting. The general steps for the single-stage photolithography process, i.e.…”

Section: Device Fabricationmentioning

confidence: 99%

Amalgamation of diverse hydrodynamic effects with novel triple-sided membrane valves for developing a microfluidic device for filterless and continuous water purification

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Lab-On-A-Chip Technology in Health Care

Mishra

2023

Lecture Notes in Electrical Engineering

View full text Add to dashboard Cite

Cost-effective smart microfluidic device with immobilized silver nanoparticles and embedded UV-light sources for synergistic water disinfection effects

Abstract: A novel microfluidic-device for water disinfection via diverse physiochemical effects has been demonstrated.

Cited by 6 publications

References 19 publications

3D-Printed Impedance Micropump for Continuous Perfusion of the Sample and Nutrient Medium Integrated with a Liver-On-Chip Prototype

3D-Printed Impedance Micropump for Continuous Perfusion of the Sample and Nutrient Medium Integrated with a Liver-On-Chip Prototype

Amalgamation of diverse hydrodynamic effects with novel triple-sided membrane valves for developing a microfluidic device for filterless and continuous water purification

Lab-On-A-Chip Technology in Health Care

Contact Info

Product

Resources

About