Cost-effective reduction of micro pollutants in the water cycle – Case study on iodinated contrast media

Strehl, Clemens; Thoene, Verena; Heymann, Lisa; Schwesig, David; Boergers, Andrea; Bloser, Marcus; Fligge, Frank; Merkel, Wolf; Tuerk, Jochen

doi:10.1016/j.scitotenv.2019.06.187

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…This cost is not expensive, making this approach economically feasible. Strehl et al estimated that adsorption treatment for the collected urine would cost ∼€5.4/patient (including €3.2 for the adsorbent and €2.2 for other costs) . Apparently, the AA/Cu(II) approach in this study is much cheaper, has no solid waste management issues, and can achieve effective deiodination.…”

Section: Resultsmentioning

confidence: 99%

“…Strehl et al estimated that adsorption treatment for the collected urine would cost ∼€5.4/patient (including €3.2 for the adsorbent and €2.2 for other costs). 76 Apparently, the AA/Cu(II) approach in this study is much cheaper, has no solid waste management issues, and can achieve effective deiodination. For practical application, the presence of other pharmaceuticals probably interferes with the reaction.…”

Section: Role Of Cu(i)mentioning

confidence: 89%

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Trace Cu(II) as an Efficient Electron-Transfer Shuttle for Reductive Deiodination of Refractory Iodinated Contrast Media Compounds

Wang,

Xu,

Cheng

et al. 2024

Environ. Sci. Technol.

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Iodinated contrast media compounds (ICMs) are intensively applied in medical diagnostic radiology and have received wide environmental concerns due to formation potential of iodinated disinfection byproducts. Conventional water/wastewater treatment processes cannot effectively remove ICMs; reducing their total organic iodine concentration is even more difficult. The source control or elimination of ICMs thus becomes necessary. We report here that the refractory ICMs (5 μM) can be efficiently deiodinated by ascorbate/ ascorbic acid (AA) (200 μM) coupled with a trace amount of Cu(II) (5 μM) through catalytic reduction but not oxidation, contrary to the conventional concept of AA/Cu(II) coupling, which produces reactive oxygen species. Taking diatrizoate (DTZ, a refractory ICM) as an example, the coupling completely deiodinated DTZ without destroying its molecular structure. High-performance liquid chromatography inductively coupled plasma mass spectrometry analysis revealed that ternary complexes form between Cu(II), ascorbate, and the anilide moiety of DTZ. Cu(II) in the ternary complex works as an efficient electron-transfer shuttle to convey electrons from ascorbate to the target compound, inducing sequential and complete deiodination. Both DTZ and the nonionic ICMs can be effectively deiodinated even in human urine. Thus, AA coupled with trace Cu(II) could be potentially useful for the source elimination of organic iodine of ICMs.

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Section: Resultsmentioning

confidence: 99%

Section: Role Of Cu(i)mentioning

confidence: 89%

Trace Cu(II) as an Efficient Electron-Transfer Shuttle for Reductive Deiodination of Refractory Iodinated Contrast Media Compounds

Wang,

Xu,

Cheng

et al. 2024

Environ. Sci. Technol.

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“…Urine interception, deployed at the patient level or hospital scale, may be used to capture and separate waste from patients on particular medicines such as cytostatic drugs and X‐ray contrast media (noPILLS in Waters, 2015; Stenuick, 2021; Strehl et al, 2019). At the hospital level, this can be achieved via specific toilets or urine bags, with the latter generally also considered a low‐cost intervention that can be easily implemented in routine hospital and at‐home patient treatments (OECD, 2022; Strehl et al, 2019).…”

Section: Waste and Wastewater Management Solutionsmentioning

confidence: 99%

Broadening the Perspective on Reducing Pharmaceutical Residues in the Environment

Helwig

Niemi

Stenuick³

et al. 2023

Enviro Toxic and Chemistry

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The present study reviews options for reducing harm from pharmaceuticals that are known to cause adverse impacts by their presence in the environment. It reviews recent global and European Union policy development, which could go further in recognizing and addressing the issue in a global context. It considers green chemistry, which can help clean up production processes but holds only long‐term promise for creating “green” alternatives. It explores the potential of health promotion and disease prevention, which can contribute significantly to a reduction of the disease burden and thus the need for medicines, both for infectious and for noncommunicable disease. Eco‐directed sustainable prescribing practices are reviewed, which have been adopted successfully to reduce the use of harmful pharmaceuticals. We note recent developments in medicines optimization and precision medicine, which hold promise for improving patient outcomes, saving costs, and reducing pharmaceutical use, through individually tailored prescribing whereby the patient codecides their therapy. Waste prevention through reuse or redistribution is beginning to find public support and “take‐back” waste disposal schemes set up via extended producer responsibility systems have achieved high returns. Finally, the paper summarizes preferred advanced wastewater technologies, including innovative low‐cost, low‐energy options. In summary, although end‐of‐pipe options have a role to play, particularly for highly concentrated wastewaters, solutions further up the medicinal chain and disease prevention interventions, informed by a broad view of health and health care, are needed to pursue a much greater potential reduction of pharmaceuticals in the environment than can be achieved by end‐of‐pipe solutions alone. Environ Toxicol Chem 2023;00:1–11. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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“…Advances in noncontrast techniques and artificial intelligence (AI) technologies allowing lower dose Gd scans 58 may reduce Gd usage. Urine bags are an effective, low‐cost measure to reduce contrast agent input into wastewater 59 . Given the low cost of mining raw Gd from ores, it seems economically unlikely that Gd recovery will be developed and employed at any scale.…”

Section: Potential Reduction Techniquesmentioning

confidence: 99%

Lifecycle of Gadolinium‐Based Contrast Agents

Liu

2020

Magnetic Resonance Imaging

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Cost-effective reduction of micro pollutants in the water cycle – Case study on iodinated contrast media

Cited by 7 publications

References 10 publications

Trace Cu(II) as an Efficient Electron-Transfer Shuttle for Reductive Deiodination of Refractory Iodinated Contrast Media Compounds

Trace Cu(II) as an Efficient Electron-Transfer Shuttle for Reductive Deiodination of Refractory Iodinated Contrast Media Compounds

Broadening the Perspective on Reducing Pharmaceutical Residues in the Environment

Lifecycle of Gadolinium‐Based Contrast Agents

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