Cost-effective flow-through nanohole array-based biosensing platform for the label-free detection of uropathogenic E. coli in real time

Gomez-Cruz, Juan; Nair, Srijit; Manjarrez-Hernández, Ángel; Gavilanes-Parra, Sandra; Ascanio, Gabriel; Escobedo, Carlos

doi:10.1016/j.bios.2018.01.055

Cited by 65 publications

(47 citation statements)

References 32 publications

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“…The interaction of light with periodic arrays of nanoholes exhibits extraordinary optical transmission (EOT) effects, thus enhancing the transmission efficiency of light at certain wavelengths. These spectral features have facilitated the development of optical arrangements that support high bulk sensitivities and permit their integration into microfluidic systems and their application for the detection of single molecules [ 62 , 63 , 64 , 65 ].…”

Section: Other Plasmonic Nanomaterial-based Strategiesmentioning

confidence: 99%

Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Mauriz

2020

Sensors

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The global burden of coronavirus disease 2019 (COVID-19) to public health and global economy has stressed the need for rapid and simple diagnostic methods. From this perspective, plasmonic-based biosensing can manage the threat of infectious diseases by providing timely virus monitoring. In recent years, many plasmonics’ platforms have embraced the challenge of offering on-site strategies to complement traditional diagnostic methods relying on the polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA). This review compiled recent progress on the development of novel plasmonic sensing schemes for the effective control of virus-related diseases. A special focus was set on the utilization of plasmonic nanostructures in combination with other detection formats involving colorimetric, fluorescence, luminescence, or Raman scattering enhancement. The quantification of different viruses (e.g., hepatitis virus, influenza virus, norovirus, dengue virus, Ebola virus, Zika virus) with particular attention to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was reviewed from the perspective of the biomarker and the biological receptor immobilized on the sensor chip. Technological limitations including selectivity, stability, and monitoring in biological matrices were also reviewed for different plasmonic-sensing approaches.

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Section: Other Plasmonic Nanomaterial-based Strategiesmentioning

confidence: 99%

Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Mauriz

2020

Sensors

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“…Another microfluidic approach to improve the biosensing performance is to exploit the nanoplasmonic structures for fluid manipulation. It is the case of flowthrough schemes utilizing plasmonic nanoapertures as nanochannels (Figure 3b), which has been employed for capturing pathogens specifically around the detection hot spots 25 . Finally, on the road towards full automation of microfluidics, numerous strategies are continuously developing including microreactors, droplet-based techniques, digital microfluidics, etc [26][27][28] .…”

Section: Integration In Portable Devicesmentioning

confidence: 99%

“…Later, Coskun et al demonstrated the applicability of the device for label-free detection of proteins with an integrated microfluidic system (Figure 3d) 31 . A similar nanoplasmonic device has been recently employed by Gomez-Cruz et al for bacteria detection, achieving a limit of detection of 100 cells/mL 25 . Current steps in this field are seeking further integration taking advantage of our daily optical devices, like smartphones.…”

Section: Integration In Portable Devicesmentioning

confidence: 99%

Label-free plasmonic biosensors for point-of-care diagnostics: a review

Soler

Huertas

Lechuga

2018

Expert Review of Molecular Diagnostics

175

126

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is a senior scientist at ICN2 in Barcelona (Spain). She obtained her PhD in 2015 working in the same Institute, specializing in nanoplasmonic biosensors for pointof-care diagnostics. After a postdoctoral stage in the Ecole Polytechnique Federale de Lausanne (EPFL, Switzerland), she is now leading the research line for the development of new optical biosensors for therapy and diagnostics applications. Cesar S. Huertas obtained his PhD at the ICN2, where he introduced and established a novel research line for the analysis of genomic and epigenomic markers using nanophotonic biosensors. Now, he works as a postdoctoral fellow at the RMIT in Melbourne (Australia), where he has a leading position in the development of diagnostics and prognostics applications for microfluidics-integrated optical biosensors.

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“…Toward the development of POC biosensing platforms, these optofluidic nanostructures are integrated into microfluidic environments in order to create fully integrated sensors compatible with portable electronics [13]. NHA-based sensors are ideal for field applications due to their small footprint and integration abilities as evidenced by recent demonstrations for the detection of bacteria, such as Chlamydia trachomatis [14], viruses, such as Ebola [15], cancer biomarkers [16] and uropathogenic bacteria [17]. Flow-through optofluidic structures also enable the enrichment of analytes in liquids by an electrohydrodynamic effect occurring around the NHAs when an electric potential and a pressure bias are applied to the fluid in a closed system [18].…”

Section: Introductionmentioning

confidence: 99%

Structural Stability of Optofluidic Nanostructures in Flow-Through Operation

2020

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Optofluidic sensors based on periodic arrays of subwavelength apertures that support surface plasmon resonance can be employed as both optical sensors and nanofluidic structures. In flow-through operation, the nanoapertures experience pressure differences across the substrate in which they are fabricated, which imposes the risk for structural failure. This work presents an investigation of the deflection and structural stability of nanohole array-based optofluidic sensors operating in flow-through mode. The analysis was approached using experiments, simulations via finite element method, and established theoretical models. The results depict that certain areas of the sensor deflect under pressure, with some regions suffering high mechanical stress. The offset in the deflection values between theoretical models and actual experimental values is overturned when only the effective area of the substrate, of 450 µm, is considered. Experimental, theoretical, and simulation results suggest that the periodic nanostructures can safely operate under trans-membrane pressures of up to 20 psi, which induce deflections of up to ~20 μm.

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Cost-effective flow-through nanohole array-based biosensing platform for the label-free detection of uropathogenic E. coli in real time

Cited by 65 publications

References 32 publications

Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Label-free plasmonic biosensors for point-of-care diagnostics: a review

Structural Stability of Optofluidic Nanostructures in Flow-Through Operation

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