Cost-Effective Analysis of the Congenital Hypothyroidism Screening Program in Sri Lanka

Karunarathna, Nuwan; Hettiarachchi, Manjula

doi:10.1016/j.vhri.2021.01.001

Cited by 6 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of them show no clinical manifestations or symptoms in the first weeks of life. In short, infants will develop mental retardation if they are not diagnosed (56)(57)(58).…”

Section: Discussionmentioning

confidence: 99%

Investigation of risk factors for congenital hypothyroidism (CH) using a population-based case-control study as part of the 2015-2018 screening program in Kohgiluyeh and Boyer Ahmad province in southwestern Iran

Jamali,

Bokaie,

Bahonar

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction and objectives: Congenital hypothyroidism (CH) is a lack of thyroid hormone at birth, crucial for brain development. A nationwide screening program has been implemented in Iran since 2005, resulting in over 12 million infants being screened and more than 30,000 patients diagnosed and treated. The incidence of CH in Iran is 2.7 per thousand live births, which is higher compared to the global incidence of 1 in 3,000 to 4,000. The incidence of CH in Kohgiluyeh and Boyer Ahmad province is significantly higher than the national and global incidence. Prognostic factors including twins, the season of birth, puberty, jaundice at birth, birth weight, gestational age, anemia and goiter of the mother, type of delivery, father's education, and smoking status are significantly associated with CH. Genetic, climatic, and environmental factors also play a role in the development of CH. Congenital hypothyroidism (CH) is one of the most common causes of intellectual disability, which can be prevented if diagnosed and treated on time. We aimed to investigate some related risk factors for CH in infants born in Kohgiluyeh and Boyer Ahmad province. Results: This was a population-based case-control study conducted on 270 infants. The study population included infants who were born between 2015 and 2018 and were subjected to a screening program for CH. In general, 135 infants diagnosed with CH who were confirmed by a specialist and had a medical record were considered as the case group and the rest (135 infants) who were healthy were considered as controls. Patients and control infants were matched in a one-to-one ratio. Information was extracted from the Sib Health Integrated System (http://sib.yums.ac.ir). Regression analysis using the logistic regression method was performed on data collected from a sample of 270 infants and SPSS software version 24 was used to analyze the data with P<0.05 considered significant. Ethical considerations were addressed by obtaining approval from the ethics committee of Yasuj University of Medical Sciences under ethical number IR.YUMS.REC.1397.136 and holding preliminary meetings with authorities, health, and medical personnel to discuss different tasks, collaboration, and completion of checklists. Conclusion: The results of the study show that among the cases studied, 3 factors, weight and height of the infant at birth and a family history of the disease in the infant could be the main risk factors for hypothyroidism (CH) in this province. Other factors such as birth order (rank), maternal age, maternal weight and height, age and mode of delivery, history of medication and iodized salt intake in the mother, diseases of the mother and father, and familial relationship of the parents were not observed to have a statistically significant association with CH. further studies are needed to analyze the results of the present study to establish the causality of these associations with greater certainty. Keywords: Neonatal hypothyroidism, risk factors, case-control study, screening, Kohgiloyeh, and Boyer Ahmad, Iran

show abstract

“…Most of them show no clinical manifestations or symptoms in the first weeks of life. In short, infants will develop mental retardation if they are not diagnosed (56)(57)(58).…”

Section: Discussionmentioning

confidence: 99%

Investigation of risk factors for congenital hypothyroidism (CH) using a population-based case-control study as part of the 2015-2018 screening program in Kohgiluyeh and Boyer Ahmad province in southwestern Iran

Jamali,

Bokaie,

Bahonar

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…All the reported CBAs on these disorders worldwide show similar results and have implemented the programme successfully for their babies. Yearly benefit to cost ratio calculated using DALY methodology for CH screening programme in Sri Lanka for the year 2011–2019 is reported to be in the range of 2.54–3.6 [ 55 ]. The benefit to cost ratio of CH newborn screening programme in the Philippines is reported to be 2.4 [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Need and Viability of Newborn Screening Programme in India: Report from a Pilot Study

Raveendran

Chacko

Prabhu

et al. 2022

IJNS

View full text Add to dashboard Cite

India, a country with the second largest population in the world, does not have a national newborn screening programme as part of its health policy. With funding support from the Grand Challenges Canada, a pilot newborn screening programme was implemented for the Udupi district of South India to study the need and viability of a national programme in India. Six disorders were selected for the study based on the availability of funding and recommendation from pediatricians in the district. Here, we report the observed incidence during the study. A cost-effectiveness analysis of implementing newborn screening in India was performed. It is evident from our analysis that the financial loss for the nation due to these preventable diseases is much higher than the overall expenditure for screening, diagnosis, and treatment. This cost-effectiveness analysis justifies the need for a national newborn screening programme in India.

show abstract

“…This is echoed by the results featured in the Indonesian Ministry of Health's Basic Health Research carried out in 2018, which revealed that 4.6% of all newborns tested for congenital hypothyroid screening through blood samples in Indonesia. When compared with other countries such as Iran which has successfully screened 98% of newborns (Yarahmadi et al, 2020), and Sri Lanka which has successfully screened 96% of newborns (Karunarathna and Hettiarachchi, 2021), Indonesia's achievements are still far from being successful in this regard. As such.…”

Section: Output Evaluationmentioning

confidence: 97%

The Evaluation of Congenital Hypothyroidsm Screening Program in Indonesia: A Literature Review

Setyaningsih

Wulandari

2022

J. Sci. n.a

View full text Add to dashboard Cite

Congenital hypothyroidism is one of the main causes of mental retardation which can be prevented. Reasearch in 2020 found that the prevalence of congenital hypothyroidism in Indonesia was 1:1167. During the previous 18 years of impelementation of the Congenital Hypothyroidsm Screening Program (CHSP), it was found that only 4,6% of newborns. This study aims to conduct a literature review to identify problems and obtain information on improving the implementation of congenital hypothyroidism screening programs in Indonesia. This research was carried out between November-December 2021 and consists of a review of a range of research articles and journals which have been publishes within the last decade. Several studies have shown that during the implementation of the CHSP, several onstacles were found which hindered the effectiveness of the program, namely the lack of training for health workers, sources of financing which have not been fully borne by the center, accuracy of collection and sample delivery, and less than optimal management function in regulating the implementation of the program thus a more in-depth evaluation needed, especially in terms of economic benefits and the level of effectiveness of the screening program.

show abstract

Cost-Effective Analysis of the Congenital Hypothyroidism Screening Program in Sri Lanka

Cited by 6 publications

References 15 publications

Investigation of risk factors for congenital hypothyroidism (CH) using a population-based case-control study as part of the 2015-2018 screening program in Kohgiluyeh and Boyer Ahmad province in southwestern Iran

Investigation of risk factors for congenital hypothyroidism (CH) using a population-based case-control study as part of the 2015-2018 screening program in Kohgiluyeh and Boyer Ahmad province in southwestern Iran

Need and Viability of Newborn Screening Programme in India: Report from a Pilot Study

The Evaluation of Congenital Hypothyroidsm Screening Program in Indonesia: A Literature Review

Contact Info

Product

Resources

About