2019
DOI: 10.1186/s12876-019-1039-4
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Cost-comparison analysis of FIB-4, ELF and fibroscan in community pathways for non-alcoholic fatty liver disease

Abstract: Background The identification of patients with advanced liver fibrosis secondary to non-alcoholic fatty liver disease (NAFLD) remains challenging. Using non-invasive liver fibrosis tests (NILT) in primary care may permit earlier detection of patients with clinically significant disease for specialist review, and reduce unnecessary referral of patients with mild disease. We constructed an analytical model to assess the clinical and cost differentials of such strategies. Methods … Show more

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Cited by 89 publications
(91 citation statements)
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“…A further two articles were identified through supplementary searches of grey literature. As such, a total of 19 articles [11,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] (capturing 16 different models) were included in the review; summary details of identified studies are shown in Table 1.…”
Section: Literature Search Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…A further two articles were identified through supplementary searches of grey literature. As such, a total of 19 articles [11,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] (capturing 16 different models) were included in the review; summary details of identified studies are shown in Table 1.…”
Section: Literature Search Resultsmentioning
confidence: 99%
“…A total of 13 articles assessed health economic outcomes associated with different screening or diagnostic strategies [16,[18][19][20][21][26][27][28][29][30][31][32][33]; five assessed outcomes with different treatments, including lifestyle intervention, pioglitazone, vitamin E and obeticholic acid as well as bariatric surgery for overweight/obese patients with NASH [17,[22][23][24][25]. The remaining article examined the overall clinical and economic burden of disease and as such was a non-comparative study [11].…”
Section: Literature Search Resultsmentioning
confidence: 99%
“…Therefore, diagnostic decisions should be made individually based on the specific case, the available diagnostic tools and the potential harms and benefits of the different diagnostic tools. Table 1 shows an overview of the advantages and disadvantages of available diagnostic tools (49).…”
Section: Diagnosticsmentioning
confidence: 99%
“…7 An improvement in referral practices and noninvasive tests has increased the rate of early detection of asymptomatic chronic liver diseases. 68 This paradigm change opens up the opportunity for mechanism-based therapies to halt disease progression during earlier (i.e., prefibrotic) phases of the disease progression. Fig.…”
Section: Before Fibrosismentioning
confidence: 99%