Abstract:Objective: The purpose of this study was to assess cost benefits of prenatal screening test for Down syndrome in developing countries (like Thailand) in order to inform OB/GYN clinical practice and medical/public health policy).Methods: A decision tree model was developed to analyze cost-benefits of the two screening modalities versus conventional screening test as base case. The first screening modality was universal Thai NIPT (Thai Non-invasive Prenatal Test) and the second was contingent Thai NIPT. Input pa… Show more
“…In contrast to our study, two previously published cost-benefit studies conducted in Thailand [25,26] suggest that implementing a universal NIPT as the primary screening method for Down syndrome (T13) was not deemed cost-beneficial. However, these studies ascertained that utilizing NIPT as a secondary screening approach was the most cost-beneficial choice.…”
Section: Plos Onecontrasting
confidence: 99%
“…Although two previously published studies have been available [25,26], it is worth noting that these studies specifically focused on evaluating the cost-benefit analysis of NIPT for Down syndrome (T21). However, they did not encompass the evaluation of Edwards (T13) and Patau syndromes (T18), which are the second and third most prevalent trisomy, respectively.…”
Section: Plos Onementioning
confidence: 99%
“…The probabilities related to trisomy incidence, miscarriage, rate of pregnancy termination, uptake rate of screening test, uptake rate of diagnostic test following a high-risk result of screening test, failure rate of NIPT, and procedure-related miscarriage were retrieved from Siriraj hospital's databases and published articles [25,30,35]. The sensitivity and specificity of…”
Section: Probabilitiesmentioning
confidence: 99%
“…First, we conducted an analysis on the cost-benefit of implementing a universal NIPT for Down syndrome (T13), Edwards syndrome (T18), and Patau syndrome (T21), while two aforementioned studies specifically focused on Down syndrome (T13) exclusively. Apart from this, the majority of the data, such as prevalence, incidence, uptake rate, and costs, were obtained from Siriraj Hospital, while a study by Oraluck et al [25] primarily relied on the findings of Pattanaphesaj et al [35], which were conducted a decade ago. Besides this, a study by Wanapirak et al [26] primarily utilized most of the data from their previous study [22].…”
Section: Plos Onementioning
confidence: 99%
“…However, from a payer perspective, its high cost renders it less viable as a primary screening method. As a result, many countries have recommended NIPT to be employed as a secondary screening option [25,26,[48][49][50]. However, it has been observed that NIPT is offered as a primary screening option for pregnant women, full reimbursement by the government in both the Netherlands and Australia [51,52].…”
Historically, there has been a lack of cost-effectiveness data regarding the inclusion of universal non-invasive prenatal testing (NIPT) for trisomy 21, 18, and 13 in the benefit package of the Universal Health Coverage (UHC) in Thailand. Therefore, this study aimed to perform the cost-benefit analysis of prenatal screening tests and calculate the budget impact that would result from the implementation of a universal NIPT program. A decision-tree model was employed to evaluate cost and benefit of different prenatal chromosomal abnormalities screenings: 1) first-trimester screening (FTS), 2) NIPT, and 3) definitive diagnostic (amniocentesis). The comparison was made between these screenings and no screening in three groups of pregnant women: all ages, < 35 years, and ≥ 35 years. The analysis was conducted from societal and governmental perspectives. The costs comprised direct medical, direct non-medical, and indirect costs, while the benefit was cost-avoidance associated with caring for children with trisomy and the loss of productivity for caregivers. Parameter uncertainties were evaluated through one-way and probabilistic sensitivity analyses. From a governmental perspective, all three methods were found to be cost-beneficial. Among them, FTS was identified as the most cost-beneficial, especially for pregnant women aged ≥ 35 years. From a societal perspective, the definitive diagnostic test was not cost-effective, but the other two screening tests were. The most sensitive parameters for FTS and NIPT strategies were the productivity loss of caregivers and the incidence of trisomy 21. Our study suggested that NIPT was the most cost-effective strategy in Thailand, if the cost was reduced to 47 USD. This evidence-based information can serve as a crucial resource for policymakers when making informed decisions regarding the allocation of resources for prenatal care in Thailand and similar context.
“…In contrast to our study, two previously published cost-benefit studies conducted in Thailand [25,26] suggest that implementing a universal NIPT as the primary screening method for Down syndrome (T13) was not deemed cost-beneficial. However, these studies ascertained that utilizing NIPT as a secondary screening approach was the most cost-beneficial choice.…”
Section: Plos Onecontrasting
confidence: 99%
“…Although two previously published studies have been available [25,26], it is worth noting that these studies specifically focused on evaluating the cost-benefit analysis of NIPT for Down syndrome (T21). However, they did not encompass the evaluation of Edwards (T13) and Patau syndromes (T18), which are the second and third most prevalent trisomy, respectively.…”
Section: Plos Onementioning
confidence: 99%
“…The probabilities related to trisomy incidence, miscarriage, rate of pregnancy termination, uptake rate of screening test, uptake rate of diagnostic test following a high-risk result of screening test, failure rate of NIPT, and procedure-related miscarriage were retrieved from Siriraj hospital's databases and published articles [25,30,35]. The sensitivity and specificity of…”
Section: Probabilitiesmentioning
confidence: 99%
“…First, we conducted an analysis on the cost-benefit of implementing a universal NIPT for Down syndrome (T13), Edwards syndrome (T18), and Patau syndrome (T21), while two aforementioned studies specifically focused on Down syndrome (T13) exclusively. Apart from this, the majority of the data, such as prevalence, incidence, uptake rate, and costs, were obtained from Siriraj Hospital, while a study by Oraluck et al [25] primarily relied on the findings of Pattanaphesaj et al [35], which were conducted a decade ago. Besides this, a study by Wanapirak et al [26] primarily utilized most of the data from their previous study [22].…”
Section: Plos Onementioning
confidence: 99%
“…However, from a payer perspective, its high cost renders it less viable as a primary screening method. As a result, many countries have recommended NIPT to be employed as a secondary screening option [25,26,[48][49][50]. However, it has been observed that NIPT is offered as a primary screening option for pregnant women, full reimbursement by the government in both the Netherlands and Australia [51,52].…”
Historically, there has been a lack of cost-effectiveness data regarding the inclusion of universal non-invasive prenatal testing (NIPT) for trisomy 21, 18, and 13 in the benefit package of the Universal Health Coverage (UHC) in Thailand. Therefore, this study aimed to perform the cost-benefit analysis of prenatal screening tests and calculate the budget impact that would result from the implementation of a universal NIPT program. A decision-tree model was employed to evaluate cost and benefit of different prenatal chromosomal abnormalities screenings: 1) first-trimester screening (FTS), 2) NIPT, and 3) definitive diagnostic (amniocentesis). The comparison was made between these screenings and no screening in three groups of pregnant women: all ages, < 35 years, and ≥ 35 years. The analysis was conducted from societal and governmental perspectives. The costs comprised direct medical, direct non-medical, and indirect costs, while the benefit was cost-avoidance associated with caring for children with trisomy and the loss of productivity for caregivers. Parameter uncertainties were evaluated through one-way and probabilistic sensitivity analyses. From a governmental perspective, all three methods were found to be cost-beneficial. Among them, FTS was identified as the most cost-beneficial, especially for pregnant women aged ≥ 35 years. From a societal perspective, the definitive diagnostic test was not cost-effective, but the other two screening tests were. The most sensitive parameters for FTS and NIPT strategies were the productivity loss of caregivers and the incidence of trisomy 21. Our study suggested that NIPT was the most cost-effective strategy in Thailand, if the cost was reduced to 47 USD. This evidence-based information can serve as a crucial resource for policymakers when making informed decisions regarding the allocation of resources for prenatal care in Thailand and similar context.
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