“…One can conceivably assume that it will also break down when the fluctuations of the stress-energy operator are large [111,237]. Calculations of the fluctuations of the energy density for Minkowski, Casimir and hot flat spaces as well as Einstein and de Sitter universes are available [86,198,237,258,259,282,302,303,304,305,313,316]. It is less clear, however, how to quantify what a large fluctuation is, and different criteria have been proposed [10,11,113,115,198,237,303,384,385].…”