Cosmetically disfiguring side effects of cyclosporine

Panicker, Vinitha Varghese; Mathew, Anil; Dhamramaratnam, AD

doi:10.4103/0974-7753.96101

Cited by 10 publications

(5 citation statements)

References 5 publications

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“…Cyclosporine A microemulsion (CyA-ME) was formulated for pediatric use because of better absorption and bioavailability than the original formulation Sandimmune. 5 However, because of the cosmetic adverse effects of CyA-ME, 6 Tacrolimus (Tac) has replaced CyA-ME. 7 Several studies have detailed the short-term adverse events of Tac immunosuppression including its effects on renal function, hypertension, dyslipidemia, cardiomyopathy, and food allergies.…”

Section: Introductionmentioning

confidence: 99%

Long-term Follow-up of a Randomized Trial of Tacrolimus or Cyclosporine A Microemulsion in Children Post Liver Transplantation

Lloyd¹,

Arshad²,

Jara

et al. 2021

Transplantation Direct

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Background. The aim of this study was to determine the long-term efficacy and safety of tacrolimus (Tac) and cyclosporine immunosuppression in pediatric liver transplantation (LTx). Methods. One hundred fifty-six patients who had taken part in a multicenter, randomized, open, parallel study of Tac and corticosteroids versus cyclosporine A microemulsion (CyA-ME), corticosteroids, and azathioprine. Patients were assessed at regular intervals up to 14 y after LTx. Analysis was conducted descriptively. Results. In a long-term follow-up, there was a similar incidence of acute rejection (Tac versus CyA-ME, 5 versus 8) and graft loss (5 versus 10). There were 11 deaths in the cohort, which were from infectious complications/malignancy in the Tac group (n = 2/5) and from chronic rejection/liver failure in the CyA-ME group (n = 3/6). A similar incidence of Epstein-Barr virus and posttransplant lymphoproliferative disease was observed (8 versus 8, 3 versus 3). However, there was a greater incidence of cosmetic adverse events in the CyA-ME cohort, with higher incidences of hypertrichosis (8 versus 27) and gum hyperplasia (20 versus 6). Growth improved equally in both groups. Overall, 81% of patients randomized to Tac remained on Tac therapy at study end, compared with 31% of patients randomized to CyA-ME. Common reasons for switching from CyA-ME included steroid-resistant/acute rejection (n = 12/8) and cosmetic changes (n = 8). Conclusions. This study is the first prospective, observational follow-up study of pediatric patients randomized to Tac and CyA-ME to evaluate long-term outcomes. Our analysis was limited by the degree of switchover between the cohorts; however, there were fewer deaths from chronic rejection/liver failure and reduced adverse events with Tac. Long-term use of Tac and Tac combination therapy appears to be safe and effective immunosuppression for pediatric LTx recipients.

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Section: Introductionmentioning

confidence: 99%

Long-term Follow-up of a Randomized Trial of Tacrolimus or Cyclosporine A Microemulsion in Children Post Liver Transplantation

Lloyd¹,

Arshad²,

Jara

et al. 2021

Transplantation Direct

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“…Steroids are expected to decrease skin thickness. CNI inhibitors are known to induce excessive hair growth, acne, and, rarely, gum hyperplasia (25). Therefore, our findings might be specific to the transplanted patients in which transplantation led to the development of a skin malignancy.…”

Section: Discussionmentioning

confidence: 69%

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas

et al. 2020

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Background/Aim: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT).It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step. Patients and Methods: We retrospectively analyzed skin biopsies of 19 non-transplanted patients with a diagnosis of SCC or basal cell carcinoma (BCC) and 17 KT with either SCC or BCC. Results: KT showed increased inflammatory infiltrate in the subepithelial region, compared to non-transplanted patients. The density of basal cell nuclei was also different among the four groups with an interaction effect between tumor type and transplantation. The extent of inflammatory infiltrates did not correlate with the eGFR and proteinuria. Conclusion: KT with a non-melanoma skin cancer show increased intact skin inflammatory infiltrate and alterations in the density of the basal cell layer compared to non-transplanted patients.

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“…Jinjival hiperplazi ve hipertrikoz CsA'nin dikkat çeken dermatolojik yan etkileridir (41)(42)(43)(44)(45) . Yalnizca bir olgunun CsA kullandiği çalişma grubumuzun tümü değerlendirildiğinde üç olguda hipertrikoz, iki olguda jinjival hiperplazi belirledik.…”

Section: Discussionunclassified

Dermatological Manifestations in Renal Transplant Recipients: A Single-centre Prospective Follow-up Study

Yorulmaz¹,

Bayrakci²,

Güneş³

et al. 2018

Okmeydani Medical Journal

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Cosmetically disfiguring side effects of cyclosporine

Cited by 10 publications

References 5 publications

Long-term Follow-up of a Randomized Trial of Tacrolimus or Cyclosporine A Microemulsion in Children Post Liver Transplantation

Long-term Follow-up of a Randomized Trial of Tacrolimus or Cyclosporine A Microemulsion in Children Post Liver Transplantation

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas

Dermatological Manifestations in Renal Transplant Recipients: A Single-centre Prospective Follow-up Study

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