Cosmetic commentary: Is bakuchiol the new "skincare hero"?

Spierings, Natalia

doi:10.1111/jocd.13708

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…Bakuchiol, the natural substitute for retinol, is a plant based natural compound playing a significant role in cosmetic and pharmaceutical industry without leaving any side effects. 12 The properties such as anti-ageing, anti-pigmentation, anti-acne, anti-cancer, hepatoprotective, cardioprotective, hypoglycemic, hypolipemic, and antidepressant, antioxidant, anti-inflammatory and antimicrobial activities makes bakuchiol a superior component in both areas of cosmetology and pharmacology. 11 d ,18 b As mentioned earlier, bakuchiol is known to be functionally similar to retinol but do not have any structural similarities.…”

Section: Bakuchiol In Cosmetologymentioning

confidence: 99%

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Bakuchiol – a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches

Krishna¹,

Baldev²,

Athalathil³

2022

RSC Adv.

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Section: Bakuchiol In Cosmetologymentioning

confidence: 99%

“… 11 Bakuchiol is found to have no or little side effects when compared to retinoids, thus replacing the latter from the place of top anti-ageing molecule. 12 This evidence suggests that bakuchiol has potential for further development, application and research.…”

Section: Introductionmentioning

confidence: 99%

Bakuchiol – a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches

Krishna¹,

Baldev²,

Athalathil³

2022

RSC Adv.

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“…Cosmetics containing retinol can cause adverse effects such as redness, itching, burning, dryness, increased skin cell turnover, increased perspiration, hair loss, or photosensitivity. However, these adverse effects have not been observed with the use of bakuchiol, which is gentler on the skin, causing minimal irritation and allergic reactions [1,55]. Furthermore, compared to retinol, bakuchiol exhibits greater photochemical stability and ease of formulation with emollients and solubilizers [64].…”

Section: Bakuchiol -A Natural Retinoid?mentioning

confidence: 99%

use of retinoids in the treatment of skin lesions and prevention of signs of skin aging - a systematic review

Zapała,

Hunek,

Kaziród

et al. 2023

J Educ Health Sport

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Retinoids are a group of substances that include vitamin A and its natural and synthetic derivatives. They are used in the treatment of various skin diseases, such as: rosacea, acne vulgaris, psoriasis. In addition, recently there is a lot of information about the action of preventing photoaging. Oral retinoids have been proven to be the most effective treatment for acne of various severity available today. Through their comprehensive action, affecting the four main factors associated with the pathogenesis of acne, they significantly reduce skin changes. Externally applied retinoids regulate the renewal of epidermal cells, stimulate the production of collagen fibers, increase the production of elastin, and lead to an increase in the number and activity of fibroblasts. Therefore, more and more people are using preparations containing retinoids to prevent skin aging. It has been proven that this procedure leads to shallower wrinkles and slows down the appearance of new ones, and evens out the skin tone. Retinoids are effective substances, but their use is associated with the risk of various side effects, the most common of which are: skin irritation, photosensitisation, headaches, muscle and joint pain, and teratogenicity.

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“…As oxidative and inflammatory stresses are closely related to cutaneous ageing, their prevention by bakuchiol might promote the overall skin condition. However, the quality of the current scientific evidence has recently been critically appraised [31]. In this context, we determined the (i) antioxidative and (ii) anti‐inflammatory capacities of bakuchiol and retinol and examined their ability to improve the cellular metabolism and synthesis of growth factor 7 summarized as (iii) cell activity.…”

Section: Introductionmentioning

confidence: 99%

Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing ‐ Experimental evidence for a holistic treatment approach

Bluemke

Ring

Immeyer

et al. 2022

Intern J of Cosmetic Sci

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Objective: Skin ageing is a multifactorial process involving formation of reactive oxygen species, consecutive inflammation with reduced epidermal and dermal cell viability and resulting damage to the extracellular matrix. Effective dermocosmetic treatment modalities should ideally address these hallmarks in a holistic approach.Here, we determined the corresponding activity profile of bakuchiol, a plant-derived meroterpene, in an array of in vitro, ex vivo and in vivo studies and compared it to retinol, currently considered as gold standard in topical antiageing cosmetics. Methods:The antioxidative capacity and power of bakuchiol and retinol were analysed by measuring 2,2′-diphenyl-1-picrylhydrazyl (DPPH) reduction via its absorption decay and electron spin resonance spectroscopy, respectively. Effects on prostaglandin E2 (PGE2), macrophage migration inhibitory factor (MIF), fibroblast growth factor 7 (FGF7), collagen type I and VII (COL1A1, COL7A1), fibronectin (FN) levels as well as the metabolization of water-soluble tetrazolium 1 (WST-1) were determined in human dermal fibroblasts. Epidermal regeneration was assessed utilizing an in vitro wound healing model. FN protein levels were analysed ex vivo after treatment with a formulation containing bakuchiol, retinol or vehicle using suction blister fluid. Skin condition improvement was determined in vivo in a split-face comparison study after application of bakuchiol or vehicle. Results:In contrast to retinol, bakuchiol demonstrated high antioxidative efficacy. Levels of PGE2 and MIF were significantly decreased by both bakuchiol and retinol. Bakuchiol but not retinol significantly increased FGF7 protein levels. WST-1 metabolization levels were significantly augmented by bakuchiol and retinol. Bakuchiol and retinol application led to a significant augmentation of COL1A1, COL7A1 and FN protein levels. Wounds supplemented with bakuchiol but not retinol displayed a significant increase in epidermis regeneration.

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Cosmetic commentary: Is bakuchiol the new "skincare hero"?

Cited by 6 publications

References 10 publications

Bakuchiol – a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches

Bakuchiol – a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches

use of retinoids in the treatment of skin lesions and prevention of signs of skin aging - a systematic review

Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing ‐ Experimental evidence for a holistic treatment approach

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