Cosmetic and personal care product use, urinary levels of parabens and benzophenones, and risk of endometriosis: results from the EndEA study

Peinado, Francisco M. Ocaña; Ocón‐Hernández, Olga; Iribarne-Durán, L.M.; Vela-Soria, Fernando; Ubiña, A.; Padilla, Carmen; Mora, J.C. Santos; Cardona, Juan de la Cruz; León, Josefa; Fernández, Mariana F.; Olea, Nicolás; Artacho‐Cordón, Francisco

doi:10.1016/j.envres.2020.110342

Cited by 34 publications

(24 citation statements)

References 72 publications

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“…Parabens are used as preservatives in cosmetics, drugs, or foods and as UV filters for sunscreens. A Spanish case-control study found higher urinary paraben levels in 35 patients with endometriosis compared with controls with no statistically significant difference [43]. Although this study used laparoscopic confirmation to identify cases and controls, several limitations are noted, including the small sample size, single urine sample collected for each patient (preventing variability in daily exposures related to the short half-lives of these substances), and no consideration of diet and smoking.…”

Section: Parabensmentioning

confidence: 97%

Endometriosis and environmental factors: A critical review

Coiplet¹,

Courbière²,

Agostini³

et al. 2022

Journal of Gynecology Obstetrics and Human Reproduction

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Section: Parabensmentioning

confidence: 97%

Endometriosis and environmental factors: A critical review

Coiplet¹,

Courbière²,

Agostini³

et al. 2022

Journal of Gynecology Obstetrics and Human Reproduction

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“…npEDCs have a low lipid solubility resulting in a relatively short half-life in humans and animals whereas POPs are highly lipophilic chemicals that are not readily biodegradable (Cho et al, 2020). Development of a variety of reproductive diseases has been found to be associated with both npEDCs (Kandaraki et al, 2011;Ye et al, 2018;Bariani et al, 2020;Peinado et al, 2021) and POPs (Heilier et al, 2004;Bruner-Tran and Osteen, 2010;Trabert et al, 2015;Al Jishi and Sergi, 2017). Due to their lipophilic nature, a number of EDCs, including dioxins and polychlorinated biphenyls (PCBs), are ubiquitously present in the environment despite regulatory steps to curtail production and manufacture.…”

Section: Environmental Endocrine Disrupting Chemicalsmentioning

confidence: 99%

The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis

et al. 2022

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Women with endometriosis, the growth of endometrial glands and stroma outside the uterus, commonly also exhibit adenomyosis, the growth of endometrial tissues within the uterine muscle. Each disease is associated with functional alterations in the eutopic endometrium frequently leading to pain, reduced fertility, and an increased risk of adverse pregnancy outcomes. Although the precise etiology of either disease is poorly understood, evidence suggests that the presence of endometriosis may be a contributing factor to the subsequent development of adenomyosis as a consequence of an altered, systemic inflammatory response. Herein, we will discuss the potential role of exposure to environmental toxicants with endocrine disrupting capabilities in the pathogenesis of both endometriosis and adenomyosis. Numerous epidemiology and experimental studies support a role for environmental endocrine disrupting chemicals (EDCs) in the development of endometriosis; however, only a few studies have examined the potential relationship between toxicant exposures and the risk of adenomyosis. Nevertheless, since women with endometriosis are also frequently found to have adenomyosis, discussion of EDC exposure and development of each of these diseases is relevant. We will discuss the potential mechanisms by which EDCs may act to promote the co-development of endometriosis and adenomyosis. Understanding the disease-promoting mechanisms of environmental toxicants related to endometriosis and adenomyosis is paramount to designing more effective treatment(s) and preventative strategies.

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“…Frequent use of cosmetics and PCPs results in higher urinary concentrations of these substances and may potentially lead to endometriosis. This is likely associated with the estrogenic and pro-oxidative effects of these compounds [ 45 ]. Oxidative stress is a recognized factor involved in the pathogenesis of endometriosis [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Environmental Factors and Endometriosis

Polak

Banaszewska

Filip

et al. 2021

IJERPH

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Endometriosis is a common disease, affecting up to 60–80% of women, with pelvic pain or/and infertility. Despite years of studies, its pathogenesis still remains enigmatic. Genetic, hormonal, environmental, and lifestyle-related factors may be involved in its pathogenesis. Thus, the design of the review was to discuss the possible role of environmental factors in the development of endometriosis. The results of individual studies greatly differ, making it very difficult to draw any definite conclusions. There is no reasonable consistency in the role of environmental factors in endometriosis etiopathogenesis.

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Cosmetic and personal care product use, urinary levels of parabens and benzophenones, and risk of endometriosis: results from the EndEA study

Cited by 34 publications

References 72 publications

Endometriosis and environmental factors: A critical review

Endometriosis and environmental factors: A critical review

The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis

Environmental Factors and Endometriosis

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