Cosmetic and dermatologic use of alpha hydroxy acids

Babilas, Philipp; Knie, Ulrich; Abels, Christoph

doi:10.1111/j.1610-0387.2012.07939.x

Cited by 43 publications

(40 citation statements)

References 20 publications

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“…A natural organic acid with a long history of application in the food, leather, cosmetic, and pharmaceutical industries [12], lactic acid has also been described as a very effective exfoliating and moisturizing agent [13]. Its application at low concentration (5% v/v) decreases intercorneocyte cohesion and induces skin peeling [14]. Therefore, different concentrations of lactic acid produce different cosmetic results in the epidermis and dermis [15].…”

Section: Introductionmentioning

confidence: 99%

Applications of Lactobacillus rhamnosus Spent Culture Supernatant in Cosmetic Antioxidation, Whitening and Moisture Retention Applications

et al. 2013

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This study was aimed at investigating the antioxidant, whitening, and moisture-retention properties of Lactobacillus rhamnosus spent culture supernatant (Lr-SCS) in cosmetic applications. Results reveal that Lr-SCS effectively and gradually scavenges 1,1-diphenyl-2-picrylhydrazyl as well as 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cations, and increases reducing power in a dose-dependent manner. Additionally, Lr-SCS can also suppress tyrosinase activity in vitro and effectively promote moisture retention. Heat treatment at 100 °C for 30 min does not influence the functions of Lr-SCS. We conclude that Lr-SCS can be used effectively in skin care cosmetics.

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Section: Introductionmentioning

confidence: 99%

Applications of Lactobacillus rhamnosus Spent Culture Supernatant in Cosmetic Antioxidation, Whitening and Moisture Retention Applications

et al. 2013

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“…Common ingredients of moisturizers with potential biological activities are α-hydroxy acids (AHAs), β-hydroxy acids (BHAs), retinoic acid, vitamins, and antioxidants 22 . As functional ingredients of moisturizers, AHAs have been widely used to improve dry skin as humectants, and also for hyperkeratotic skin as keratolytic agents 23 . Lactic acid, a monocarboxylic acid AHA, has been widely used to relieve itch as an ingredient of moisturizers for AD patients 19 .…”

Section: Discussionmentioning

confidence: 99%

CSP0510 Lotion as a Novel Moisturizer Containing Citric Acid and Trisodium Phosphate Relieves Objective and Subjective Symptoms of Atopic Dermatitis

et al. 2016

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BackgroundMoisturizers with anti-inflammatory or anti-itch activity should be developed for the safe and effective management of atopic dermatitis (AD).ObjectiveThis study evaluated the efficacy of a newly developed moisturizer, CSP0510 lotion (Twolines Inc., Korea), containing citric acid (CA) and trisodium phosphate (TSP) as active ingredients, in mild to moderate AD.Methods and ResultsCSP0510 lotion applied twice daily for 4 weeks to eczematous lesions improved objective and subjective (itch) symptoms of AD. The physician's global assessment (PGA) score for objective symptoms decreased from 2.5±0.6 before application to 1.3±0.5 after application in the CSP0510-treated group (n=42, p<0.001). Also, the PGA score decreased from 2.3±0.6 to 1.9±0.5 by vehicle-treated (without CA and TSP) control group (p=0.001), but there was no statistical difference between CSP0510-treated and vehicle-treated groups (p=0.089). The visual analogue scale score for itch decreased from 4.8±1.3 to 2.0±0.9 in the CSP0510-treated group (p<0.001), and from 4.6±1.1 to 3.5±0.9 in the control group (p=0.075), showing a statistical significance between two groups (p=0.002). Our results in humans were further supported by in vitro and animal experiments. In HaCaT cells treated with compound 48/80 (7.5 µg/ml), CA:TSP (1:1, vol:vol) synergistically suppressed the compound 48/80-induced upregulation of thymic stromal lymphopoietin, nerve grow factor, and calcitonin gene-related peptide. Application of CSP0510 to the dorsal skin of hairless mice for 3 weeks suppressed the oxazolone-induced allergic skin inflammation.ConclusionIn conclusion, CSP0510 lotion has anti-itch and anti-inflammatory activity in the skin, which improves both objective and subjective symptoms of AD.

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“…Asam laktat merupakan bahan pelembab dan exfoliating (pengelupasan kulit mati). Aplikasi asam laktat pada konsentrasi rendah (5% v/v) menurunkan kohesi interkorneosit dan mengelupaskan sel kulit mati [3]. Asam laktat mampu menghambat aktivitas enzim yang bertanggung jawab dalam pencoklatan kulit yaitu tirosinase [4].…”

Section: Pendahuluanunclassified

UJI PENGHAMBATAN TIROSINASE MASKER GEL PEEL OFF YANG MENGANDUNG RUMPUT LAUT (Euchema cotonii) DAN WHEY KEFIR

Fatmawati

2020

INA RESEARCH PHA

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Whey adalah cairan yang merupakan hasil pengendapan pada proses pembuatan keju, yoghurt ataupun kefir. Whey mengandung nutrisi yang lengkap. Whey telah banyak digunakan dalam dunia kesehatan, industri makanan, industri fermentasi dan juga pakan ternak. Penelitian ini bertujuan untuk mendapatkan formula terbaik masker gel peel off dimana telah dibuat 5 variasi formulasi serta menguji penghambatan tirosinase dari sediaan masker gel peel off tersebut. Metode yang digunakan pada penelitian ini meliputi fermentasi kefir, uji evaluasi masker yang meliputi uji pH, uji waktu mengering, uji daya sebar, uji viskositas, uji iritasi dan uji penghambatan tirosinase. Pengujian dilakukan pada hari ke 0 sampai hari ke 21. Berdasarkan hasil pengujian diperoleh bahwa formula terbaik dari masker whey susu kambing dan susu sapi berturut-turut didapatkan dari formula 3 dan 4. Sedangkan nilai IC50 pada sediaan masker gel peel off dari whey susu kambing dan susu sapi masi-masing sebesar 1.19% dan 6.14% dengan kontrol positif yang digunakan adalah asam kojat

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Cosmetic and dermatologic use of alpha hydroxy acids

Cited by 43 publications

References 20 publications

Applications of Lactobacillus rhamnosus Spent Culture Supernatant in Cosmetic Antioxidation, Whitening and Moisture Retention Applications

Applications of Lactobacillus rhamnosus Spent Culture Supernatant in Cosmetic Antioxidation, Whitening and Moisture Retention Applications

CSP0510 Lotion as a Novel Moisturizer Containing Citric Acid and Trisodium Phosphate Relieves Objective and Subjective Symptoms of Atopic Dermatitis

UJI PENGHAMBATAN TIROSINASE MASKER GEL PEEL OFF YANG MENGANDUNG RUMPUT LAUT (Euchema cotonii) DAN WHEY KEFIR

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