Cosmetic Analysis Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging  (MALDI-MSI)

Oliveira, Diogo Noin de; Sartor, Sabrina de Bona; Ferreira, Mônica Siqueira; Catharino, Rodrigo Ramos

doi:10.3390/ma6031000

Cited by 28 publications

(33 citation statements)

References 21 publications

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“…Quantification by imaging is a very interesting feature that has been described by Grey et al (Grey et al 2011) and recently implemented in our group in as a relative quantification approach (de Oliveira et al 2013a). The present work has aimed to provide absolute values for compound quantification by using external standards and analytical curves.…”

Section: Resultsmentioning

confidence: 99%

“…The technique, known as MALDI mass spectrometry imaging (MSI), was developed to identify the spatial distribution of compounds in any physical sample, such as tissue sections (Solon 2007), drug tablets (Earnshaw et al 2010), and cosmetic products (de Oliveira et al 2013a). Despite its ingenuity, MSI's operating principle is very straightforward: an infrared or ultraviolet laser beam is focused on a sample and "scans" all over its extension in quick shots, generating a mass spectrum in each spot, just like a pixel, forming a molecular image at the end of the process (Caprioli et al 1997).…”

Section: Introductionmentioning

confidence: 99%

“…Our group has proposed an innovative study applied to cosmetic products, which changed the concept of "qualitative analysis-only" for MALDI-MSI. We were able to perform a relative quantification of the Sudan III dye directly in nail polishes, employing ImageJ, a software commonly used as a tool for western blot quantification (de Oliveira et al 2013a;Gassmann et al 2009). …”

Section: Introductionmentioning

confidence: 99%

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MALDI-MSI: a fast and reliable method for direct melatonin quantification in biological fluids

et al. 2016

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Background: This work reports, for the first time, a validated methodology for qualitative and quantitative melatonin analyses directly from a complex matrix, namely rat milk, using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), in a useful strategy for fast assessment of this molecular species. Methods: This novel approach uses the imaging feature of a MALDI instrument to create bidimensional images of a selected area. Results for sample concentration are expressed as a function of pixel-by-pixel intensity in grayscale, which are quantified according to pixel intensity through ImageJ open source software. For the extent of this work, two conditions were monitored: light-and dark-obtained milk.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MALDI-MSI: a fast and reliable method for direct melatonin quantification in biological fluids

et al. 2016

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“…196 The application of MALDI MSI as a quality control tool of cosmetic products was presented by de Oliveira et al 103 Upon the lipid profiles it was possible to test if a lipstick or eyeliner was expired or not. the skin care, or odor of our body due to the rapid increase of our population.…”

Section: Cosmetomicsmentioning

confidence: 99%

MALDI mass spectrometric imaging meets “omics”: recent advances in the fruitful marriage

Crecelius

Schubert

Eggeling

2015

Analyst

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Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI MSI) is a method that allows the investigation of the molecular content of surfaces, in particular, tissues, within its morphological context. The applications of MALDI MSI in the field of large-scale mass spectrometric studies, which are typically denoted by the suffix "omics", are steadily increasing. This is because, on the one hand, technical advances regarding sample collection and preparation, matrix application, instrumentation, and data processing have enhanced the molecular specificity and sensitivity of MALDI MSI; on the other hand, the focus of the "omics" community has moved from establishing an inventory of certain compound classes to exploring their spatial distribution to gain novel insights. Thus, the aim of this mini-review is twofold, to display the state-of-the-art in terms of technical aspects in MALDI MSI and to highlight selected applications in the last two years, which either have significantly advanced a certain "omics" field or have introduced a new one through pioneering efforts.

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“…To overcome the shortcomings of frozen-section histology, a series of analytical methods have been gradually developed and established. These include desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) 16–18 , matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) 19–21 , rapid evaporative ionization-mass spectrometry (REIMS) 6, 7, 22 , and tip-spray ionization-mass spectrometry (TSI-MS) 23 . Although DESI-MSI and MALDI-MSI are more efficient than frozen-section histology, they are time-consuming methods due to the sampling, sectioning, and imaging processes.…”

Section: Introductionmentioning

confidence: 99%

Rapid discrimination of human oesophageal squamous cell carcinoma by mass spectrometry based on differences in amino acid metabolism

Zhang

Ouyang

et al. 2017

Sci Rep

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Oesophageal cancer (OC) is associated with high morbidity and mortality, and surgery is the most effective approach to treat it. In order to reduce surgical risks and duration of surgery, we explored a new strategy to determine tumour margins in surgery. In this study, we included 128 cancerous and 128 noncancerous database entries obtained from 32 human patients. Using internal extractive electrospray ionization-MS, in positive ion detection mode, the relative abundances of m/z 104.13, m/z 116.10, m/z 132.13, and m/z 175.13 were higher in cancer tissue while the relative abundances of m/z 82.99, m/z 133.11, m/z 147.08, m/z 154.06, and m/z 188.05 were higher in normal tissue. Using partial least squares analysis, the mass spectra of cancer samples was discriminated from those of normal tissues, and the discriminatory ions were obtained from loading plots. Dimethylglycine(m/z 104), proline(m/z 116), isoleucine(m/z 132), asparagine(m/z 133), glutamine(m/z 147), and arginine(m/z 175) were identified by collision-induced dissociation experiments. Using the ROC curve analysis, we verified the validity of six amino acids for the identification of tumour tissue. Further investigations of tissue amino acids may allow us to better understand the underlying mechanisms involved in OC and develop novel means to identify tumour tissue during operation.

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Cosmetic Analysis Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI)

Cited by 28 publications

References 21 publications

MALDI-MSI: a fast and reliable method for direct melatonin quantification in biological fluids

MALDI-MSI: a fast and reliable method for direct melatonin quantification in biological fluids

MALDI mass spectrometric imaging meets “omics”: recent advances in the fruitful marriage

Rapid discrimination of human oesophageal squamous cell carcinoma by mass spectrometry based on differences in amino acid metabolism

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