Cosmeceuticals and peptides

Zhang, Lijuan; Falla, Timothy J.

doi:10.1016/j.clindermatol.2009.05.013

Cited by 99 publications

(111 citation statements)

References 90 publications

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“…Acetyl hexapeptide-3 has been used in anti-aging topical formulations due to its effects in improving the skin appearance (Blanes-Mira et al, 2002;Zhang, Falla, 2009). However there are few basic studies about its effects on skin, as well as, about its mechanism of action.…”

Section: Resultsmentioning

confidence: 99%

Acetyl hexapeptide-3 in a cosmetic formulation acts on skin mechanical properties - clinical study

Tadini

Mercúrio

Campos

2015

Braz. J. Pharm. Sci.

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Acetyl hexapeptide-3 has been used in anti-aging topical formulations aimed at improving skin appearance. However, few basic studies address its effects on epidermis and dermis, when vehiculated in topical formulations. Thus, the objective of this study was to determine the clinical efficacy of acetyl hexapeptide-3 using biophysical techniques. For this purpose, formulations with and without acetyl hexapeptide-3 were applied to the ventral forearm and the face area of forty female volunteers. Skin conditions were evaluated after 2 and 4-week long daily applications, by analyzing the stratum corneum water content and the skin mechanical properties, using three instruments, the Corneometer® CM 825, Cutometer  SEM 575 and Reviscometer  RV600. All formulations tested increased the stratum corneum water content in the face region, which remained constant until the end of the study. In contrast, only formulations containing acetyl hexapeptide-3 exhibit a significant effect on mechanical properties, by decreasing the anisotropy of the face skin. No significant effects were observed in viscoelasticity parameters. In conclusion, the effects of acetyl hexapeptide-3 on the anisotropy of face skin characterize the compound as an effective ingredient for improving conditions of the cutaneous tissue, when used in anti-aging cosmetic formulations.Uniterms: Acetyl hexapeptide-3/use in cosmetic formulations. Acetyl hexapeptide-3/clinical efficacy. Biophysical techniques. Anti-aging/cosmetics. Clinical efficacy. Cosmetics.Acetil hexapeptídeo-3 tem sido utilizado como um ingrediente ativo em formulações tópicas antienvelhecimento para a melhoria da aparência cutânea. No entanto, poucos estudos avaliam seus efeitos na epiderme e derme, quando veiculado em formulações tópicas. Portanto, o objetivo desse estudo foi a determinação da eficácia clínica de acetil hexapeptídeo-3 utilizando técnicas de biofísica e de análise de imagem. Para tal, formulações contendo, ou não, acetil hexapeptídeo-3 foram aplicadas no antebraço volar e na face de voluntárias. As condições cutâneas foram avaliadas após duas e quatro semanas de aplicação diária das formulações, por meio da análise no conteúdo aquoso do estrato córneo e avaliação das propriedades mecânicas da pele, utilizando os equipamentos Corneometer® CM 825, Cutometer  SEM 575 e Reviscometer  RV600. Todas as formulações avaliadas aumentaram o conteúdo aquoso do estrato córneo na face, o qual permaneceu constante até o fim do estudo. Por outro lado, somente as formulações contendo acetil hexapeptídeo-3 apresentaram efeito significativo nas propriedades mecânicas, por meio da diminuição da anisotropia da pele na face. Não foram observados efeitos significativos para os parâmetros de viscoelasticidade. Em conclusão, os efeitos de acetil hexapeptídeo-3 na pele caracteriza este peptídeo como um ingrediente ativo efetivo para a melhoria das condições cutâneas, quando utilizadas em formulações cosméticas.Unitermos: Acetil hexapeptídeo-3/uso em cosméticos. Acetil hexapeptídeo-3/eficácia clínica....

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Section: Resultsmentioning

confidence: 99%

Acetyl hexapeptide-3 in a cosmetic formulation acts on skin mechanical properties - clinical study

Tadini

Mercúrio

Campos

2015

Braz. J. Pharm. Sci.

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“…Next, 2% LE, MW, and MY or a control were applied to the UVB irradiated sites (6 sites for each) for 24 h. The erythema index (EI) was measured before and 24 h after occlusion and EI differences ( EI) were observed. into individual natural amino acids [14]. Peptides act through protein-protein interaction.…”

Section: Discussionmentioning

confidence: 99%

Novel anti-inflammatory peptides as cosmeceutical peptides

Kang

Choi

et al. 2011

Peptides

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“…Of particular note, the biodiversity of oceanic islands is often underestimated [9]. In addition to the ecological impact of a decrease in snake species richness, these extinctions have economic consequences: venoms have applications in many fields including medicine, pharmacology and immunology [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Vintage venoms: Proteomic and pharmacological stability of snake venoms stored for up to eight decades

Jesupret

Baumann

Jackson

et al. 2014

Journal of Proteomics

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For over a century, venom samples from wild snakes have been collected and stored around the world. However, the quality of storage conditions for "vintage" venoms has rarely been assessed. The goal of this study was to determine whether such historical venom samples are still biochemically and pharmacologically viable for research purposes, or if new sample efforts are needed. In total, 52 samples spanning 5 genera and 13 species with regional variants of some species (e.g., 14 different populations of Notechis scutatus) were analysed by a combined proteomic and pharmacological approach to determine protein structural stability and bioactivity. When venoms were not exposed to air during storage, the proteomic results were virtually indistinguishable from that of fresh venom and bioactivity was equivalent or only slightly reduced. By contrast, a sample of Acanthophis antarcticus venom that was exposed to air (due to a loss of integrity of the rubber stopper) suffered significant degradation as evidenced by the proteomics profile. Interestingly, the Keywords:Mass spectrometry Toxinology Stability studies These results demonstrate that with proper storage techniques, venom samples can retain structural and pharmacological stability. This article is part of a Special Issue entitled:Proteomics of non-model organisms. Biological significance• These results show that with proper storage venoms are useful for decades.• These results have direct implications for the use of rare venoms.

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Cosmeceuticals and peptides

Cited by 99 publications

References 90 publications

Acetyl hexapeptide-3 in a cosmetic formulation acts on skin mechanical properties - clinical study

Acetyl hexapeptide-3 in a cosmetic formulation acts on skin mechanical properties - clinical study

Novel anti-inflammatory peptides as cosmeceutical peptides

Vintage venoms: Proteomic and pharmacological stability of snake venoms stored for up to eight decades

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