Coryneform Bacteria in Throat Cultures of Healthy Individuals

Graevenitz, Alexander von; Pünter-Streit, V.; Riegel, Philippe; Funke, Guido

doi:10.1128/jcm.36.7.2087-2088.1998

Cited by 61 publications

(25 citation statements)

References 15 publications

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“…This in turn suggests that asymptomatic carriage of C. diphtheriae is not uncommon, but C. diphtheriae throat carriage has been described to be rare or absent among patients with upper respiratory tract infections and asymptomatic individuals . However, these studies involved few socially/professionally active and healthy subjects and bacterial flora of the upper respiratory tract in infected patients may not be representative of that in the general population . Asymptomatic throat carriage may also concern only a particular sub‐population or may be transient, and cutaneous carriage has not been evaluated.…”

Section: Discussionmentioning

confidence: 99%

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Microbiological changes and diversity in autochthonous non-toxigenic Corynebacterium diphtheriae isolated in France

Farfour

Badell

Dinu

et al. 2013

Clinical Microbiology and Infection

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Autochtonous toxigenic Corynebacterium diphtheriae have disappeared in mainland France, but non-toxigenic C. diphtheriae are still circulating. Using phenotypic and molecular tools, we retrospectively characterized 103 non-toxigenic C. diphtheriae collected in mainland France and highlight several changes. The proportion of C. diphtheriae belfanti increased between 1977 and 2011 and it is the most frequent biotype recovered in recent years. Resistance to ciprofloxacin has increased and most isolates with decreased sensitivity belong to the belfanti biotype. Using multilocus sequence typing, we demonstrate that French isolates are distributed in a large number of sequence types and identify three distinct lineages. C. diphtheriae mitis and gravis form lineage I while C. diphtheriae belfanti forms lineages II and III. Almost all isolates of lineage II are part of a unique clonal complex or are very close to it. Most French isolates have a dtxR sequence homologous to that of toxigenic isolates, suggesting that if lyzogenised by a corynephage, they can express diphtheria toxin.

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Section: Discussionmentioning

confidence: 99%

“…ST181 does not share any allele with other French C. diphtheriae belfanti. We compared the nucleotide sequences at each locus by NCBI blast, and the rpoB sequence was homologous to that of a C. diphtheriae belfanti isolate collected from the ear of a cat . The feline isolate carries the tox gene but does not express the diphtheria toxin.…”

Section: Discussionmentioning

confidence: 99%

Microbiological changes and diversity in autochthonous non-toxigenic Corynebacterium diphtheriae isolated in France

Farfour

Badell

Dinu

et al. 2013

Clinical Microbiology and Infection

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“…This group of bacteria includes members of the genera Corynebacterium, Brevibacterium, Dermabacter, Microbacterium, Rothia, Turicella, Arthrobacter, and Oerskovia as well as several other genera. Coryneform bacteria are widely distributed in the environment as commensals colonizing the skin and mucous membranes of humans and other animals, [27][28][29] and are commonly considered contaminants without clinical significance. 30,31 However, the high percentage of coryneform bacteria isolates found in this study, and the presence of coryneform bacteria with other pathogenic bacteria in some cases, may allow reasonable challenge of this assumption.…”

Section: Discussionmentioning

confidence: 99%

Bacteremia in Equine Neonatal Diarrhea: A Retrospective Study (1990–2007)

Hollis¹,

Wilkins²,

Palmer³

et al. 2008

Veterinary Internal Medicne

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Background: Bacteremia in sick foals is associated with survival, but the association of bacteremia and diarrhea is not reported.Hypothesis: Neonatal foals with diarrhea will commonly be bacteremic. Animals: One hundred and thirty-three neonatal foals.Methods: Records of all foals o30 days of age presenting with diarrhea between January 1990 and September 2007 were reviewed.Results: Sixty-six of 133 foals (50%) were bacteremic at admission, with 75 isolates from the 66 samples. The blood culture from a further 18 foals (13.5%) grew coryneform bacteria. Nine foals (6.8%) had 2 or more organisms grown on blood culture. One foal had 5 different organisms, interpreted as contamination. Forty-eight foals (36%) had no growth on admission blood cultures. No cultures isolated fungal organisms. Excluding coryneform bacteria, 43 isolates (57%) were Gram-negative organisms and 32 isolates (43%) were Gram-positive organisms. The most common isolate was Enterococcus spp. (22 isolates, 29%), followed by Pantoea agglomerans (13 isolates, 17%). IgG concentration at admission was not associated with blood culture status. Blood culture status was not associated with survival to hospital discharge.Conclusions and Clinical Importance: Bacteremia is common in neonatal foals with diarrhea. Decisions regarding antimicrobial selection should be made with these differences in mind.

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“…The current database lists 98% of all Rothia spp. as catalase positive, but a very recent study demonstrated that up to one-third of all Rothia strains are catalase negative (9). Other minor modifications of the RapID CB Plus database which seem to be necessary (Table 2) include the introduction of pyrrolidonyl aminopeptidase-positive Arcanobacterium pyogenes and Corynebacterium minutissimum strains, proline aminopeptidase-negative CDC group G and Oerskovia strains, and glycosidase-positive Rothia strains.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the RapID CB Plus System for Identification of Coryneform Bacteria andListeriaspp

1998

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In a stress test, the recently introduced RapID CB Plus system (Remel Inc. [formerly Innovative Diagnostic Systems], Norcross, Ga.) was challenged with a diverse set of gram-positive rods comprising 345 strains of coryneform bacteria and 33 strains of Listeriaspp. representing a total of 49 different taxa. Overall, within 4 h, the system correctly identified 80.9% of the strains on the species level and 12.2% of the strains on the genus level. Only 3.7% strains were misidentified, and for 3.2% of the strains no identification was provided. Difficulties with the system were mainly due to occasional uncertainties in reading reactions for acid production from carbohydrates and, to a lesser extent, aminopeptidase reactions. It is concluded that the system may also perform well under the conditions of a routine clinical laboratory.

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Coryneform Bacteria in Throat Cultures of Healthy Individuals

Cited by 61 publications

References 15 publications

Microbiological changes and diversity in autochthonous non-toxigenic Corynebacterium diphtheriae isolated in France

Microbiological changes and diversity in autochthonous non-toxigenic Corynebacterium diphtheriae isolated in France

Bacteremia in Equine Neonatal Diarrhea: A Retrospective Study (1990–2007)

Evaluation of the RapID CB Plus System for Identification of Coryneform Bacteria andListeriaspp

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