Corynebacteriumamycolatum causing breast abscess: An infecting Diphtheroid with a difference

Butta, Hena; Pasha, Feroz; Dawar, Reetika; Kashyap, Vikas; Mendiratta, Leena; Bora, Upasana; Sardana, Raman

doi:10.21276/apalm.1456

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…We have earlier reported a case of breast abscess with fistula formation due to C.amycolatum at our institute. [11] We believe that in the earlier years we would have isolated Corynebacteria from breast specimens but it would have been considered as of doubtful significance because of non-definitive identification of the isolate. MALDITOF MS has thus played a vital role in understanding the significance of these species from breast pus/tissue specimens.…”

Section: Discussionmentioning

confidence: 98%

Non-diphtheriae Corynebacteria Causing Breast Abscess in Non-lactating Females Seeking to Avoid Pitfalls in Diagnosis of Chronic Breast Infections Through Diagnostic Stewardship

Sardana¹,

Butta²,

Gilotra³

et al. 2022

Ann of Pathol and Lab Med

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Background: Consideration of non-diphtheriae Corynebacteria as an infective organism in mastitis, is usually neglected. So, infections due to Corynebacterium species may remain undiagnosed or misdiagnosed. The aim of our study was to focus on non-diphtheriae Corynebacterium as causative organisms in breast infections using scientific logic and technology of Matrix Assisted Laser Desorption Ionisation Time of Flight Mass Spectrometry (MALDITOF MS) to categorize the isolates upto species level. The clinical correlation and response to management especially targeted antimicrobials was also recorded. Methods: All the consecutive pus/tissue samples from Breast abscess received during study period were processed as per the standard guidelines. The identification of the isolate was done by automated methods. The cytopathological/histopathological and clinical details of the patients with infection due to Corynebacterium sp. were recorded and analyzed. Results: Out of 52 non-duplicate samples, five showed growth of non-diphtheriae Corynebacteria. These were identified as C. kroppenstedtii and C. amycolatum. The antimicrobial susceptibility testing showed 100% susceptibility to Amoxicillin-clavulanate, Tetracycline, Vancomycin and Linezolid for all the five isolates. Histopathological examination was suggestive of chronic inflammatory mastitis/Granulomatous mastitis. Conclusion: Non diphtheriae Corynebacteria particularly lipophilic Corynebacteria have a predilection to cause infections of breast tissue and Breast abscess which may mimic as tubercular abscess or chronic non-specific mastitis leading to unnecessary usage of antimicrobials. So, these isolates from breast tissue/pus should not be ignored rather definitely identified. This would also ensure diagnostic stewardship.

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Section: Discussionmentioning

confidence: 98%

Non-diphtheriae Corynebacteria Causing Breast Abscess in Non-lactating Females Seeking to Avoid Pitfalls in Diagnosis of Chronic Breast Infections Through Diagnostic Stewardship

Sardana¹,

Butta²,

Gilotra³

et al. 2022

Ann of Pathol and Lab Med

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“… 1 C. amycolatum is also a part of the skin flora, which has recently been reported to manifest various infections such as sepsis, device‐associated infections, endocarditis, empyema, and breast abscess. 1 , 4 In skin and soft tissue infections, C. amycolatum has been isolated from wound and surgical site infections. 5 , 6 Cases in immunocompromised conditions can be fatal.…”

Section: Discussionmentioning

confidence: 99%

“…Historically, Corynebacterium species have been underrated and ignored as a contaminant, as they are normal colonisers of the skin and generally show low virulence 1 . C. amycolatum is also a part of the skin flora, which has recently been reported to manifest various infections such as sepsis, device‐associated infections, endocarditis, empyema, and breast abscess 1,4 . In skin and soft tissue infections, C. amycolatum has been isolated from wound and surgical site infections 5,6 .…”

Section: Discussionmentioning

confidence: 99%

Multiple subcutaneous abscesses by Corynebacterium amycolatum in a patient with severe idiopathic aplastic anaemia

Shintani,

Fukushima‐Nomura,

Funakoshi

et al. 2024

Skin Health and Disease

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Corynebacterium amycolatum is a part of the normal skin flora and has been underestimated as a pathogen. However, in recent years, the species has gained recognition as an important pathogen causing severe infections, particularly in immunocompromised patients. Nevertheless, identifying these organisms at the species level is difficult in routine clinical microbiology, leading to limited knowledge of their clinical manifestations in infectious diseases. In this study, we report a rare case of multiple subcutaneous abscesses in a patient with severe neutropenia, wherein C.amycolatum was identified as the causative organism through genotyping tests. This case highlights the importance of this organism as an aetiological agent of severe skin infections in patients with compromised immune systems.

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“…After doxycycline treatment, surgical intervention was not needed in this patient 22 . In a case report of breast abscess with fistula formation, Butta et al performed abscess drainage and fistula excision, continued the treatment with amoxicillin+clavulanic acid 1000mg (875/125mg) and doxycycline 200 mg for 7 days upon isolation of C. amycolatum in the tissue sample and reported that the patient responded fully to the treatment and recovered completely 23 . In our study to investigate the role of Corynebacterium strains in the etiology of granulomatous mastitis, tissue samples obtained from 41 patients were examined microscopically in terms of the number of microorganisms, staining characteristics and shapes of the existing microorganisms, and C. amycolatum was isolated from only 1 patient (2.4%).…”

Section: Discussionmentioning

confidence: 99%

The Role of Corynebacterium in The Etiology of Granulomatous Mastitis

YAMAN,

GİRGİN,

AKPOLAT

et al. 2023

J Cukurova Anesth Surg

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Introduction: Granulomatous mastitis (GM) is a rare, benign, chronic inflammatory illness of the breast. It is characterized by necrotizing granulomatous lobulitis of the breast that clinically mimics breast cancer. The aim of this study was to examine the existence of Corynebacterium strains thought to be covered in the etiology of idiopathic granulomatous mastitis. Material and Methods: In this study, we retrospectively analyzed the results of 201 breast tru-cut biopsies carry out for diagnostic purposes in the Department of General Surgery. The tissue samples of 41 patients with histopathologically diagnosed GM were examined by Gram staining. The existence of Corynebacterium kinds was investigated microscopically by adding appropriate medium. Results: The mean age of 41 female patients with GM was 35. 7 years and the age range was 20-58 years. At the end of the study, Corynebacterium amycolatum was defined as the causative microorganism as a consequence of microbiologic examination of the tissue sample of one patient (2.4%). Conclusion: We consider that Corynebacterium is not the etiologic agent of GM. Additionally studies with large case series are needed to explain the etiology.

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Corynebacteriumamycolatum causing breast abscess: An infecting Diphtheroid with a difference

Cited by 5 publications

References 5 publications

Non-diphtheriae Corynebacteria Causing Breast Abscess in Non-lactating Females Seeking to Avoid Pitfalls in Diagnosis of Chronic Breast Infections Through Diagnostic Stewardship

Non-diphtheriae Corynebacteria Causing Breast Abscess in Non-lactating Females Seeking to Avoid Pitfalls in Diagnosis of Chronic Breast Infections Through Diagnostic Stewardship

Multiple subcutaneous abscesses by Corynebacterium amycolatum in a patient with severe idiopathic aplastic anaemia

The Role of Corynebacterium in The Etiology of Granulomatous Mastitis

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