Corynebacterium xerosis as a cause of vertebral osteomyelitis

Krish, Guha; Beaver, Walter B.; Sarubbi, Felix A.; Verghese, Abraham

doi:10.1128/jcm.27.12.2869-2870.1989

Cited by 14 publications

(5 citation statements)

References 14 publications

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“…There are 12 recent reports of C. xerosis infections; eight of these infections occurred after surgery or antibiotic therapy (infections of protheses, postsurgical wound infection, nosocomial pneumonia, infection of a pancreatic pseudocyst, and spontaneous peritonitis) (11,34,167,232,238,256,437,446,461). In five cases, the isolates were described as multiply resistant (167,232,256,446,461), supporting the contention that the strains were C. amycolatum.…”

Section: Nonlipophilic Fermentative Corynebacteriamentioning

confidence: 78%

Clinical microbiology of coryneform bacteria

et al. 1997

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Coryneform bacteria are aerobically growing, asporogenous, non-partially-acid-fast, gram-positive rods of irregular morphology. Within the last few years, there has been a massive increase in the number of publications related to all aspects of their clinical microbiology. Clinical microbiologists are often confronted with making identifications within this heterogeneous group as well as with considerations of the clinical significance of such isolates. This review provides comprehensive information on the identification of coryneform bacteria and outlines recent changes in taxonomy. The following genera are covered: Corynebacterium, Turicella, Arthrobacter, Brevibacterium, Dermabacter. Propionibacterium, Rothia, Exiguobacterium, Oerskovia, Cellulomonas, Sanguibacter, Microbacterium, Aureobacterium, "Corynebacterium aquaticum," Arcanobacterium, and Actinomyces. Case reports claiming disease associations of coryneform bacteria are critically reviewed. Minimal microbiological requirements for publications on disease associations of coryneform bacteria are proposed.

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Section: Nonlipophilic Fermentative Corynebacteriamentioning

confidence: 78%

Clinical microbiology of coryneform bacteria

et al. 1997

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“…Genotyping techniques such as PCR as well as sequence analysis of the rpo B C53 isolate in this study contributed greatly towards a correct species identification, which was originally misleading when using phenotypic microscopic and biochemical features. Corynebacterium xerosis has been previously reported in clinical samples of human cases in lesions in endocarditis, pneumonitis, osteomyelitis and skin infections, especially in immunocompromised patients [ 3 , 12 ]. It has also been found in animal clinical samples, for instance, in goat liver lesions (suspected pseudotuberculosis), and cow milk, from animals presenting mastitis.…”

Section: Case Presentationmentioning

confidence: 99%

Identification and molecular characterization of Corynebacterium xerosis isolated from a sheep cutaneous abscess: first case report in Mexico

et al. 2016

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BackgroundCorynebacterium xerosis is a commensal organism found in skin and mucous membranes of humans. It is considered an unusual pathogen, and it is rarely found in human and animal clinical samples. Here we describe the isolation of C. xerosis from a 4-months-old Pelifolk lamb located in Tesistán, central western Mexico. This microorganism should be considered for differential diagnosis in cutaneous abscessed lesions in sheep, as it represents a zoonotic risk factor for human infection in sheep farms.Case presentationThe animal exhibited a hard-consistency, 5 cm diameter abscess, without drainage, in the neck. The presumptive clinical diagnosis was caseous lymphadenitis, caused by Corynebacterium pseudotuberculosis. Samples were obtained by puncture and cultured in 8 % sheep blood agar under microaerophilic conditions. Colonies were non-haemolytic, brown-yellowish and showed microscopic and biochemical features similar to C. pseudotuberculosis, except for the urea test. A multiplex-PCR for the amplification of partial sequences of the pld, rpoB and intergenic fragment from 16S to 23S genes suggested that isolate could be C. xerosis, which was later confirmed by sequencing analysis of the rpoB gene.ConclusionsThis study shows for the first time isolation and molecular characterization of C. xerosis from a clinical sample of an ovine cutaneous abscess in Mexico. This finding highlights the need for differential diagnosis of this pathogen in ovine skin abscesses, as well as epidemiological and control studies of this pathogen in sheep farms.

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“…These microorganisms were called "Group JK bacteria." 7,8 Later in 1987, Corynebacteria belonging to the group JK, that were associated with endocarditis, were taxonomically described to represent a new species within this genus called C. jeikeium based on polyacrylamide gel electrophoresis of cellular proteins and DNA-DNA hybridization studies. 9 C. jeikeium is part of healthy human skin flora, most commonly present in the axillary, inguinal and rectal regions.…”

Section: Epidemiologymentioning

confidence: 99%

“…isolated from clinical specimens (primarily blood cultures) were characterized morphologically and biochemically by the United States Centers for Disease Control and Prevention. These microorganisms were called “Group JK bacteria.” 7,8 Later in 1987, Corynebacteria belonging to the group JK, that were associated with endocarditis, were taxonomically described to represent a new species within this genus called C. jeikeium based on polyacrylamide gel electrophoresis of cellular proteins and DNA-DNA hybridization studies. 9 C .…”

Section: Epidemiologymentioning

confidence: 99%

Corynebacterium Jeikeium Endocarditis

Gupta

Popli

Ranchal

et al. 2020

Cardiology in Review

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Corynebacterium jeikeium is a gram-positive, aerobic, pleomorphic, nonspore forming bacillus, commonly present on the skin surface. Infective endocarditis secondary to C. jeikeium most commonly affects leftsided heart valves and has a higher likelihood to require valve replacement compared to other Corynebacterium endocarditis. C. jeikeium endocarditis is extremely difficult to treat as it is characteristically resistant to penicillin, cephalosporins and aminoglycosides, and sensitivity to quinolones, macrolides, tetracyclines and rifampin is variable. Despite treatment, mortality rates as high as 33% have been reported. We hereby review the literature regarding the epidemiology, diagnosis and treatment of this deadly microorganism.

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Corynebacterium xerosis as a cause of vertebral osteomyelitis

Cited by 14 publications

References 14 publications

Clinical microbiology of coryneform bacteria

Clinical microbiology of coryneform bacteria

Identification and molecular characterization of Corynebacterium xerosis isolated from a sheep cutaneous abscess: first case report in Mexico

Corynebacterium Jeikeium Endocarditis

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