Corynebacterium Striatum, an Emerging Nosocomial Pathogen: Case Reports

Gupta, Varsha; Gupta, Mrinal; Pal, Kritika; Chander, Jagdish

doi:10.2174/1871526520666200224103405

Cited by 5 publications

(7 citation statements)

References 9 publications

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“…To the best of our knowledge, there are no previous reports of isolated Corynebacterium tuberculostearicum mediated CIED infection . Corynebacterium striatum is an emerging multidrug resistant nosocomial pathogen capable of causing a variety of infections in immunocompromised and hospitalized patients 41,42 . Corynebacterium striatum has been associated with both native and prosthetic valve endocarditis and bone and joint infections 43,44,45 .…”

Section: Discussionmentioning

confidence: 99%

“…Corynebacterium striatum is an emerging multidrug resistant nosocomial pathogen capable of causing a variety of infections in immunocompromised and hospitalized patients. 41 , 42 Corynebacterium striatum has been associated with both native and prosthetic valve endocarditis and bone and joint infections. 43 , 44 , 45 However, CIED infections with Corynebacterium striatum are rare with only four patients reported to date.…”

Section: Discussionmentioning

confidence: 99%

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Atypical pathogens associated with cardiac implantable electronic device infections

Kohli

Hazra

Ahmed

et al. 2021

Pacing Clinical Electrophis

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Background Cardiovascular implantable electronic device (CIED) infections are associated with significant morbidity and mortality making the identification of the causative organism critical. The vast majority of CIED infections are caused by Staphylococcal species. CIED infections associated with atypical pathogens are rare and have not been systematically investigated. The objective of this study is to characterize the clinical course, management and outcome in patients with CIED infection secondary to atypical pathogens. Methods Medical records of all patients who underwent CIED system extraction at the University of Chicago Medical Center between January 2010 and November 2020 were retrospectively reviewed to identify patients with CIED infection. Demographic, clinical, infection‐related and outcome data were collected. CIED infections were divided into typical and atypical groups based on the pathogens isolated. Results Among 356 CIED extraction procedures, 130 (37%) were performed for CIED infection. Atypical pathogens were found in 5.4% (n = 7) and included Pantoea species (n = 2), Kocuria species (n = 1), Cutibacterium acnes (n = 1), Corynebacterium tuberculostearicum (n = 1), Corynebacterium striatum (n = 1), Stenotrophomonas maltophilia (n = 1), and Pseudozyma ahidis (n = 1). All patients with atypical CIED infections were successfully treated with total system removal and tailored antibiotic therapy. There were no infection‐related deaths. Conclusions CIED infections with atypical pathogens were rare and associated with good outcome if diagnosed early and treated with total system removal and tailored antimicrobial therapy. Atypical pathogens cultured from blood, tissue or hardware in patients with CIED infection should be considered pathogens and not contaminants.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Atypical pathogens associated with cardiac implantable electronic device infections

Kohli

Hazra

Ahmed

et al. 2021

Pacing Clinical Electrophis

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Section: Discussionmentioning

confidence: 99%

“…We report here the first deep septic thrombophlebitis and bacteraemia superimposed by multidrug-resistant Corynebacterium striatum in France. The increasing uses of invasive devices, aggressive antimicrobial therapies and immunosuppressive treatments can only lead to these types of nosocomial infections [3,25]. In the absence of a consensus on the general recommendations to treat C. striatum septic deep thrombophlebitis, we suggest that treatment should associate the removal of the medical device with at least 4-6 weeks of susceptibility-directed antibiotic treatment, starting with vancomycin, or daptomycin used in biantibiotherapy, and 6 weeks of anticoagulation therapy.…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium striatum thrombophlebitis: a nosocomial multidrug-resistant disease?

Tang

Kornblum

Godefroy

et al. 2021

Access Microbiology

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Introduction. Corynebacterium striatum is a non-Diphteriae commensal bacterium with a wide range of pathogenicity. The identification of multidrug-resistant (MDR) C. striatum is concerning because drug susceptibility testing is not usually performed in microbiology laboratories. There is no consensus yet on the treatment of septic thrombophlebitis in this situation. Case report. We report here the first case of a quinquagenarian patient with a history of AIDS and fungic endocarditis, who was diagnosed with a nosocomial thrombophlebitis in the right jugular vein caused by C. striatum . Bitherapy with daptomycin for 12 days and linezolid for 23 days was combined with a therapeutic anticoagulant. The follow-up included weekly cervical ultrasound controls. The efficiency of the treatment and the stability of the lesions allowed us to alleviate the medication with a prophylactic dose of anticoagulant. The patient was discharged from hospital and showed no signs of recurrence after 12 months. Conclusion. The lack of consensus relative to the management of septic thrombophlebitis precludes the validation of a specific treatment for the condition. Our results suggest that a combination that includes removal of the medical device is needed. A total of 6 weeks of antibiotherapy should be applied, starting with 2 weeks of vancomycin or a combination of antibiotitherapy with daptomycin in order to reduce the bacterial load and avoid resistance. Six weeks of anticoagulation therapy is effective.

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“…To provide an example of the feasibility of B-AMP for in silico evaluation of AMPs with anti-biofilm potential, we present a case study using the emerging pathogen Corynebacterium striatum . C. striatum is a multidrug resistant, biofilm-forming pathogen, increasingly associated with a range of wound, skin and eye infections ( Watkins et al., 1993 ; Wong et al., 2010 ; Alibi et al., 2017 ; McMullen et al., 2017 ; Nudel et al., 2018 ; Datta et al., 2021 ). In C. striatum , the sortase-pilin machinery is known to be important for biofilm formation, encoding the pilus-specific sortase C enzyme ( de Souza et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

AMPing Up the Search: A Structural and Functional Repository of Antimicrobial Peptides for Biofilm Studies, and a Case Study of Its Application to Corynebacterium striatum, an Emerging Pathogen

Mhade¹,

Panse²,

Tendulkar³

et al. 2021

Front. Cell. Infect. Microbiol.

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Antimicrobial peptides (AMPs) have been recognized for their ability to target processes important for biofilm formation. Given the vast array of AMPs, identifying potential anti-biofilm candidates remains a significant challenge, and prompts the need for preliminary in silico investigations prior to extensive in vitro and in vivo studies. We have developed Biofilm-AMP (B-AMP), a curated 3D structural and functional repository of AMPs relevant to biofilm studies. In its current version, B-AMP contains predicted 3D structural models of 5544 AMPs (from the DRAMP database) developed using a suite of molecular modeling tools. The repository supports a user-friendly search, using source, name, DRAMP ID, and PepID (unique to B-AMP). Further, AMPs are annotated to existing biofilm literature, consisting of a vast library of over 10,000 articles, enhancing the functional capabilities of B-AMP. To provide an example of the usability of B-AMP, we use the sortase C biofilm target of the emerging pathogen Corynebacterium striatum as a case study. For this, 100 structural AMP models from B-AMP were subject to in silico protein-peptide molecular docking against the catalytic site residues of the C. striatum sortase C protein. Based on docking scores and interacting residues, we suggest a preference scale using which candidate AMPs could be taken up for further in silico, in vitro and in vivo testing. The 3D protein-peptide interaction models and preference scale are available in B-AMP. B-AMP is a comprehensive structural and functional repository of AMPs, and will serve as a starting point for future studies exploring AMPs for biofilm studies. B-AMP is freely available to the community at https://b-amp.karishmakaushiklab.com and will be regularly updated with AMP structures, interaction models with potential biofilm targets, and annotations to biofilm literature.

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Corynebacterium Striatum, an Emerging Nosocomial Pathogen: Case Reports

Cited by 5 publications

References 9 publications

Atypical pathogens associated with cardiac implantable electronic device infections

Atypical pathogens associated with cardiac implantable electronic device infections

Corynebacterium striatum thrombophlebitis: a nosocomial multidrug-resistant disease?

AMPing Up the Search: A Structural and Functional Repository of Antimicrobial Peptides for Biofilm Studies, and a Case Study of Its Application to Corynebacterium striatum, an Emerging Pathogen

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